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Analytical Instrumentation

Analytical Theory

Biological, Medical, and Clinical Analysis

Biopharmaceutical Perspectives

Biopharmaceuticals and Protein Analysis

Cannabis Analysis

Capillary Electrophoresis

Chiral Chromatography

ChromAcademy

Corporate Profiles

Data Acquisition, Handling, and Archiving

Data Analysis, Statistics, and Chemometrics

Dietary Supplements Analysis

Environmental Analysis

Field-Flow Fractionation (FFF)

Food and Beverage Analysis

Forensics, Narcotics

From the Editor

GC–MS

Gas Chromatography (GC)

LCGC TV: Gas Chromatography

LCGC TV: Hyphenated Techniques

LCGC TV: Liquid Chromatography

LCGC TV: Sample Preparation

LC–MS

Liquid Chromatography (LC/HPLC)

Peer-Reviewed Articles

Pharmaceutical Analysis

Preparative-Scale Chromatography

Process Analytical Technology (PAT)

Quality Control/Quality Assurance (QA/QC)

Quality by Design (QbD)

Regulatory Standards, GLP and GMP Compliance

Sample Preparation

Size-Exclusion Chromatography (SEC)

Solid-Phase Extraction (SPE)

Supercritical Fluid Chromatography (SFC)

Supercritical Fluid Extraction (SFC)

The Next Generation

Thin Layer Chromatography

Trends

UHPLC

Web of Science

Sample Preparation

Latest News

Two glasses of red wine in the vineyard | Image Credit: © Rostislav Sedlacek - stock.adobe.com

New Study Tests Dried Spot Sampling for Red Wine Characterization

By Aaron Acevedo

June 25th 2025

A new dried spot-based technique involving untargeted liquid chromatography coupled with high-resolution mass spectrometry was testing for characterizing foodstuffs.

Mary Ellen McNally is an FMC Fellow at the Stine Research Center for FMC Corporation. Dr. McNally was named to the Analytical Scientist Power List as one of the Top 50 most influential women in the analytical sciences, has received the American Microchemical Society Steyermark Award in the field of microanalysis, the Chromatography Forum of Delaware Valley Award for contributions to the field of chromatography, and has been recognized for her contributions to the field of supercritical fluids by the Midwest SFC Discussion and the Tri-State Analytical Supercritical Fluid Discussion Groups.

New Sample Preparation Products and Accessories for 2024–2025

By Mary Ellen P. McNally

June 5th 2025

This article reports on new products introduced at Pittcon this year and in the preceding year related to sample preparation instruments, supplies, and accessories.

Nathalie Delaunay, Audrey Combès, and Valérie Pichon © Images courtesy of authors.

HPLC 2025 Preview: Functionalized Monoliths as Selective Sample Preparation Materials

By Nathalie Delaunay
Audrey Combès

Valérie Pichon

May 16th 2025

Analyzing trace compounds from complex samples often requires purification and pre-concentration, and online coupling of solid-phase extraction (SPE) with liquid chromatography (LC) helps minimize analysis time and solvent/sample use. Monoliths with large macropores are ideal for this coupling due to their low back pressure and versatility in various formats.

Pipette, liquid and test tube in laboratory for science experiment, chemical analysis and sample preparation. Equipment, closeup and dropper for medical research, biochemistry and solution mixing. | Image Credit: © CoetzeeRising/peopleimages.com

Sample Preparation of Drug Substances and Products in Regulated Testing: A Primer

By Michael W. Dong

May 13th 2025

Michael Dong recently discussed sample preparation (SP) techniques for small-molecule drug substances and solid dosage forms.

Adrián de la Fuente and Silvia Valverde Bastardo © Image courtesy of interviewees

A Sustainable Approach to Green Sample Preparation and Analytical Performance Using HS-SPME-GC–QTOF-MS

By Kate Jones

April 23rd 2025

LCGC International spoke to Adrián de la Fuente and Silvia Valverde Bastardo from the University of Valladolid, Spain, about the development of a miniaturized headspace solid-phase microextraction gas chromatography–quadrupole time-of-flight mass spectrometry (HS-SPME-GC–QTOF-MS) method for the analysis of biogenic volatile organic compounds (BVOCs) emitted by native Spanish trees.

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