Sample Preparation

Modern autosamplers and workstations possess a range of capabilities, in addition to simple liquid handling, that allow automation of sample preparation steps traditionally performed manually.

A review article that summarizes the successful sample preparation strategies that have led to some of the highest peptide and protein identification rates reported in the literature

In contrast to isocratic separations, gradient elution can sometimes seem to be counter-intuitive. Yet with the proper perspective, the things we intuitively understand about isocratic methods apply in a similar manner to gradients.

The authors present the most common and fundamental techniques that address common matrix issues and discuss the critical chemistry considerations.

This article gives an overview of research into carbon nanotubules and their potential applications in chromatography and sample preparation.

The results from a reader survey on sample preparation techniques

This short review covers the use of ionic liquids (ILs) and polymeric ionic liquids (PILs) in solid-phase microextraction (SPME) and dispersive microextraction (DLLME)

Ionic liquids have tunable selectivity for specific classes of analytes, giving them distinct advantages over organic solvents.

Howard G. Barth and Ronald E. Majors Liquid–solid extraction is the most popular method, but sometimes modern approaches such as PLE/ASE and MAE are possible.

This instalment focuses on approaches and techniques for extracting and concentrating small molecules of interest present in polymeric materials.

This article discusses the details of how the newer techniques of sample preparation are simplified by the use of LC–MS-MS and GC–MS-MS technology.

Well, the vacation is over and I've certainly come back down to earth with a bump!

Congratulations, LCGC, on 30 successful years of reporting on the current trends in chromatography. Certainly, this is an accomplishment that we in the separations community have enjoyed and benefited from, and we wish you many more happy years of success.

Purification of Monoclonal Antibodies Using Various Modes of Analytical Chromatography

Sample preparation is a crucial part of the analysis of foodstuffs. Current sample preparation techniques used in food analysis are reviewed and the advantages and drawbacks of each one are discussed.

LC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?

The current state of economic affairs is tumultous; as the economy struggles to bounce back, companies across all industries are becoming more creative in finding ways to reduce costs without sacrificing the quality of their goods or services. According to a recent survey conducted by the Society of Forensic Toxicologists (SOFT), 64.5% of forensic labs surveyed are implementing changes, or plan to implement changes, as a result of limited resources.

Turbulent flow chromatography is often used for on-line sample cleanup of biological matrices in liquid chromatography–mass spectrometry applications.

Part I of this series explains how lipids analysis has evolved.

Examples of a wide variety of sample preparation techniques for the analysis of trace-level contaminants in food and the advantages and disadvantages of each are discussed in this article.

Gathering information about the chemical and physical properties of target analytes is an essential step to effective solid-phase extraction (SPE) method development.

Sample preparation is the basis for all separations-related research.

Describes practical aspects of hollow-fibre liquid-phase microextraction in the three phase mode (HF3LPME) and also electromembrane extraction (EME).

A presentation of the overall trends in liquid-phase chromatography observed at the symposium, as well as the awards presented and the opening plenary session

Polymers are sensitive molecules. Depending on the polymer architecture or copolymer composition, it is possible to have bonds present along the polymer chain that can easily be broken.