Sample Preparation

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Karolinska University Hospital researchers recently tested new approaches for analyzing drugs of abuse in oral fluids.

An automated solid-phase extraction (SPE) method has been developed to detect cyanotoxins in water.

Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.

This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.

Hydrophobic deep eutectic solvents have proven useful in extracting non-polar target compounds, though researchers have shown there is room for further development.

Webinar Date/Time: Wed, Apr 9, 2025 10:00 AM EDT

Aflatoxins are a family of toxins made by certain fungi that are found on agricultural crops, such as maize (corn), peanuts, and cottonseed.

Nadia Gadi and Allisson Barros de Souza spoke to LCGC International about their investigation into the application of electrochemical advanced oxidation processes (eAOPs) for the efficient removal of pharmaceutical residues in wastewater.

Webinar Date/Time: Thursday, April 17, 2025 8am PST | 11am EST | 4pm GMT | 5pm CET

Webinar Date/Time: Wednesday, April 2nd, 2025 Session 1: 8:00 AM PDT | 11:00 AM EDT | 4:00 PM BST Session 2: 11:00 AM PDT | 2:00 PM EDT Thursday, April 3rd, 2025 Session 3: 11:00 AM JST | 10:00 AM CST

A study has compared solid-phase extraction (SPE) to traditional normal-phase liquid column chromatography (LCC) methods for the analysis of hydrocarbons by gas chromatography–mass spectrometry (GC–MS).

In this month's edition of the LCGC Blog, Emanuela Gionfriddo discusses chromatography resources that can help make the field more accessible to newcomers and veterans alike.

Webinar Date/Time: Thursday, March 20, 2025 8am PST | 11am EST | 4pm GMT | 5pm CET

Thermal desorption and gas chromatography-tandem mass spectrometry were used to create a method for detecting airborne polycyclic aromatic hydrocarbon (PAH) samples.

A team of researchers has evaluated approaches in exposome research, highlighting sample preparation, MS-based platforms, and data acquisition strategies.

A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.

You're invited to publicize your 2024–2025 new product introductions in LCGC. Here's how to get your products included.

In this edition of The LCGC Blog, Jonathan Shackman discusses what factors to consider when choosing a mobile phase for liquid chromatography (LC) procedures.

A European Union reference laboratory recently created a new method for analyzing gas chromatography (GC)-amenable pesticides in foods of animal origin.

Shihezi University scientists recently developed a new imprinted structure to separate acteoside (ACT) from other substances within Cistance tubulosa, or “desert ginseng.”

Harbin University of Commerce and Northeast Forestry University scientists led efforts to create new means of analyzing components in traditional Chinese medicine.

A recent joint study between the University of Ferra and YMC ChromaCon led an effort to a new approach to more efficiently purify oligonucleotides.

Throughout 2024, the editors of LCGC International attended chromatography conferences across the globe. Below, you’ll find a sampling and overview of our conference coverage from the year.

An LC–HRMS approach for the simultaneous analysis of 15 N-nitrosamines in multiple APIs using a novel HILIC-based SPE clean-up step has been developed and tested.

This article describes the current highlights of using molecular imprinted polymers (MIPs) in sample preparation.

The Chromatographic Society (ChromSoc) has announced the winners of the Martin Medal and the Silver Jubilee Medal for 2025. Professor Bogusław Buszewski of Nicolaus Copernicus University in Torun, Poland, has been awarded the prestigious Martin Medal, and the 2025 Silver Jubilee Medal has been awarded to Elia Psillakis of the Technical University of Crete in Greece.