UHPLC

In the world of liquid chromatography, innovative strides in column technology continue to take place. We are also reminded that there is always more to learn about “well-known” methodologies, and our craft is continuously influenced by important social concerns.

Governments are striving to implement policy changes towards a greater use of green technology, specifically around the generation of energy. Individuals and industrial organizations have also taken up the challenge, and now many companies are driving to significantly reduce their environmental footprint, or indeed become carbon negative within very short time frames.

This paper describes advances in column design that enable the analyst to achieve high sensitivity and efficiency when reducing the internal diameter of the column.

In this edition of The LCGC Blog, Emanuela Gionfriddo discusses the two world-class scientists and trailblazer women in separation chemistry and the awards they received at Pittcon 2024.

Tony Edge, Stephane Moreau, Carsten Paul, and Fraser McLeod discuss the latest trends and developments in LC.

How long should you perform an extraction of woodruff leaves so that you don’t end up with a harmful amount of coumarin, but still get the characteristic flavor of the finished May wine?

As opposed to targeted metabolomics which looks only at a predetermined set of metabolites or their pathways, an untargeted approach was preferred by this research team because of its unbiased yet still comprehensive nature.

The flowmeter, Testa said in a press release, was compared favorably as an alternative to more traditional flow calibration methods for HPLC pumps.

In this interview for ASMS 2024, Liusheng Huang of the University of California San Francisco discusses his upcoming presentation about performing microvolume analysis on antimalarial drugs.

Xinyi Biyan is a Chinese patent medicine with significant therapeutic effects, widely used clinically to treat acute and chronic rhinitis or allergic rhinitis.

Scientists from Changchun University of Chinese Medicine used UHPLC-Q-Orbitrap-MS/MS analysis to identify the active compounds in TongFu XieXia Decoction for treating intestinal obstruction.

Scientists from the Lunan Pharmaceutical Group explored the use of UHPLC-MS/MS to test the effects of Shouhui Tongbian capsules (SHTBs) on slow transit constipation (STC).

This article covers liquid chromatography columns and accessories commercially released after Pittcon 2023 through the 2024 conference.

Here are the top five articles that the editors of LCGC International published this week.

Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.

Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.

Here are the top five articles that the editors of LCGC International published this week.

Chromatographic and spectroscopic techniques alike were reviewed for their current effectiveness and future potential in this lecture session at Analytica 2024.

This article describes newly introduced high-performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products in 2023–2024. It summarizes their technical specifications and significant user benefits.

The 26th Norwegian Symposium on Chromatography was held 21–23 January 2024. The symposium has strong traditions in the Norwegian separation science community, serving as a forum for excellent scientific talks, networking, and social events.

In a recent study out of Boehringer Ingelheim Animal Health USA Inc. in North Brunswick, New Jersey, scientists investigated cloruson and its related substances using an original ion-paired reversed phase ultraperformance liquid chromatography (IP-UHPLC) method.

In a recent study out of Central South University in Changsha, China, scientists tested different cosine similarity algorithms to test for illegal adulterants in drugs.

Here are the top five articles that the editors of LCGC International published this week.

In a recent study, scientists tested how effective dynorphin 1-17 peptides can be in treating chronic rhinosinusitis with nasal polyps (CRSwNP).

A recent study dissects a Chinese herbal medicine to determine why it is effective in treating polycystic ovary syndrome (PCOS).

Scientists from Hangzhou, China used ultra-performance liquid chromatography mass spectrometry and non-targeted metabolomics studies to help find treatments for colorectal cancer.

Alyssa Sanchez of Florida International University presented her research on profiling the decomposition of heroin from South America, Mexico, Southwest and Southeast Asia.

Researchers from Nanjing University of Chinese Medicine leveraged ultrahigh-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) and network pharmacology to identify potential quality markers of three processed Qingpi products and elucidate their mechanism in liver disease treatment.

Researchers employed advanced chromatography and mass spectrometry techniques to unravel the chemical components and metabolites of Lingbao Huxin Dan, pinpointing its therapeutic potential for cardiovascular ailments.

Scientists in Mexico developed a new method for detecting herbicides in agricultural soil, being based on techniques like 9-fluorenylmethyl chloroformate (FMOC-Cl) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).