Application Notes: General

Discover the results obtained with the PerkinElmer GC 2400™ Platform for the analysis according to USP grade Carbomer 940.

A synthetic peptide panel is screened on the HALO® Peptide PCS C18 and compared to a standard peptide C18 stationary phase.

Built upon Fused-Core® technology, the HALO® PCS C18 maintains peak symmetry at high loading capacities and provides alternate selectivity for C18 bonded phases.

Ambient air analysis and study of the new IONICON Fusion PTR-TOF, providing ultrahigh sensitivities up to 80 000 cps/ppbV, high mass resolving power and ppqV detection limit

The new HALO® PCS C18 phase offers an alternative to chromatographic separations.

In a head-to-head SPP comparison of two positively charged C18 surface chemistries, the HALO 90 Å PCS C18 obtains improved resolution, efficiency, and tailing factors.

Discover the integrated GC 2400™ System and HS 2400™ Headspace Sampler for USP 467.

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent analysis according to USP requirements, showing improved productivity and lab time optimization.

Expert insights on purification workflows in pharmaceutical labs, challenges in managing data, and the role of data automation solutions in data analysis and integration.

Identification of polyphenolic catechin compounds for health and industrial quantification and quality control of tea products.

Nine structurally diverse, strongly basic drug compounds are resolved in less than 2 minutes using a high pH mobile phase and a fast acetonitrile gradient at 80 °C.

The diterpenoid, paclitaxel, is as a potent chemotherapy agent for breast and ovarian cancer. Here, the isolation of paclitaxel from its major impurities is shown.

Chemically resistant resin bed allows for a wide base of mobile phase choices with excellent anion separation

Identifying benzodiazepine metabolites can be highly valuable in detecting abuse. Metabolites of oxazepam are found containing both hydroxyl and glucuronides.

A reversed-phase HPLC method was developed to separate five steroid hormones, with partition coefficients ranging from 1.47 (cortisone) to 4.5 (pregnenolone).

Complementarity in chromatography ensures accurate purity. Daicel offers non-chiral stationary phases compatible in different modes for cyclic peptide analysis.

The common artificial sweeteners acesulfame K, saccharin and cyclamate Na were analysed using a YMC-Triart C18 UHPLC column in less than 10 min via MS/MS detection.

This tech note describes a method of continuous monitoring of flow rate to provide real-time validation of the LC system performance, improving reliability of results.

GPC/SEC-viscometry enables measurement of true molar masses for carrageenan and detects subtle differences between samples with similar molar mass distributions.

GPC/SEC-MALLS analysis of hyaluronic acid obtains absolute molar mass while conventional GPC/SEC with concentration detectors only provides apparent molar masses.

This technical overview discusses best handling practices for IVT mRNA and analysis with the Fragment Analyzer systems, including sample handling and quantification tips.

A validated method was developed for screening short to long chain PFAS in industrial water, using direct injection with no sample preparation.

Discover how SEC can be used in biopolymer applications including bioconjugates, proteins, mAbs, mRNA1, viruses, extracellular vesicles, and liposomal nanoparticles.

A multimodal method using HILIC and anion ion exchange chromatography for high peak resolution was developed to separate ultra-short to medium chain PFAS.

Utilizing the Shodex HILIC VT-50 2D, a method was developed on LC–MS to analyze ultra-short chain (C1¬–C4) PFAS though long chain (C8–C10) PFAS.

A validated method was developed for screening short to long chain PFAS in ground water, using direct injection with no sample preparation.

This paper discusses sustainable solutions for size separation of macromolecules that align with the 12 principles of green chemistry.