Application Notes: General

Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.

GC headspace analysis is commonly used to control volatile organic components in APIs. Methods are specified in U.S. Pharmacopeia General Chapter <467>.

Mesylate and besylate are potentially genotoxic impurities in pharmaceuticals. This app note introduces analysis of sulfonic acid esters utilizing Shimadzu's GCMS-QP.

Nexera Prep with LCMS-2050 and Open Solution software provide a seamless workflow for drug discovery from screening to purification and purity check.

Untargeted comparison of flavour profiles of popular brand soft drinks using immersive sorptive extraction, GCxGC–TOF-MS and chemometrics.

Characterising various petrochemicals – diesel, crude oil and vacuum gas oil – using the enhanced peak capacity of GC×GC-FID with SepSolve’s new thermal modulator.

Some nitrosamine compounds are classified as probably carcinogenic to humans. This application note describes the analysis of six nitrosamines by LC–MS/MS.

Shimadzu provides a number of solutions for the analysis of impurities in pharmaceutical products, as described in this Application Notebook.

USP General Chapter <1469> ensures appropriate control of NSAs in drug products. This application replicates NSA determination in APIs using Shimadzu's GCMS-TQ8050 NX.

This demonstrates how to perform cannabis potency analysis using HPLC-UV, displaying the advantages of this technique for analyzing acidic cannabinoids.

Application note shows how thermal desorption GC–MS is used to monitor the release of PFAS during the application of aqueous film-forming foam (AFFF).

Demonstrating how commercially available TD equipment is used to monitor CF4 & other products of incomplete destruction (PIDs) resulting from PFAS removal technologies.

Download our application note to learn how to test for cannabinoids in biological samples and discover a method offering the required sensitivity for drug tests.

This study investigates the performance of a high-throughput automated thermal desorption instrument coupled to GC–MS/MS for PFAS analysis.

This application note utilises SCION's GC-MS to test for cannabinoids, providing method conditions and sample preparation techniques to validate methods.

Measuring PFAS pollution in ambient air with TD–GC–MS/MS at concentrations low as 2 pg/m3. Each of 19 targeted compounds had linear calibration with high repeatability.

This application note provides insights into how to monitor the different cannabis strains, and showcases how the Horwitz ration can be a useful tool in this analysis.

This application note demonstrates the performance of SCION's GC combined with FID, showcasing its higher sample throughput.

Discover how Headspace GC-MS is used to test cannabis samples for residual solvents and pesticides in this application note.

Discover the advantages of using GC-FID for cannabis terpene testing, and see our expert advice on method validation for the technique.

High-quality data is critical in the pharmaceutical industry. Chromatography Data Systems (CDS) are helping organizations ensure data integrity, compliance with regulatory requirements, and the production of safer medicines.

Accurate determination of flow rate is an increasingly favoured method of assessing or validating the performance of a pump serving a liquid chromatography system.

Identifying and Mitigating Contamination Ions in Mass Spectrometry: A Comprehensive Guide

The solvent of choice for scientists involved with trace-level and research and analyses.

Reveal PFAS dark matter using high-resolution ion mobility (HRIM) to enhance existing chromatographic methods and provide richer insights into samples.

Important qualities of mobile phase additives for LC-MS analysis

This application note explains how and what to automate to streamline the reaction optimization process and generate comprehensive results for a full plate in minutes.