Application Notes: General

This application note demonstrates the performance of SCION's GC combined with FID, showcasing its higher sample throughput.

Automated high-capacity sorptive extraction with GC–MS for screening wine, at ppb levels, for two yeast-derived spoilage compounds in wine.

Today’s SFC systems are widely accepted for analytical and preparative separation of chiral and achiral compounds related to pharmaceutical development. Shimadzu enhances the user experience by delivering a highly effective integration of analytical and prep SFC supported by a unified software platform. Learn how these solutions can be used for rapid screening of multiple analytical conditions, simplified method development, and purification at laboratory scale.

Whether you're an experienced user of SFC technology or just getting into it, this FAQ guide offers a wealth of knowledge to enhance your efficiency, troubleshoot common issues, and make the most of this dynamic tool. Learn about a wide range of topics, including hardware insights, advantages of SFC, applications, and column screening and matrix effects.

SFC can provide solutions for challenging separations beyond traditional normal- and reverse-phase HPLC. But to get the best results, you need to select the right columns. This eBook examines column options for accurately and efficiently separating a variety of pharmaceutical compounds using SFC. Topics include SFC column fundamentals and considerations, selecting SFC columns, and columns for SFC chiral and achiral analysis.

In gas chromatography (GC) analysis, the use of proper high-purity gases is critical to the speed and accuracy of analysis. Laboratories worldwide are taking control of their gas supply with onsite gas generation as a safe and economical way to stabilize gas costs while improving the speed of analysis. LCGC recently sat down with Rod Wilson, Product Manager of Parker Hannifin’s Analytical Gas Business, to discuss the advantages of Parker gas generators.

The Nexera UC UHPLC/SFC switching system combines both UHPLC and SFC analysis modes in a single system, allowing you to easily switch between the two techniques in as few as ten minutes without reconnecting flow lines. So, you get the added resolution of UHPLC and the added selectivity of SFC to quickly develop separations without compromising chromatographic accuracy. Learn about five key benefits.

Accurate purity assessment of oligonucleotide mixtures can be challenging due to their complexity. Daicel offers several solutions that provide unique selectivity.

This application note emphasizes the assessment criteria and key factors to consider when evaluating and choosing chromatographic methods.

The measurement of adenosine nucleotides represents important diagnostic measures concerning metabolic standing for the determination of various pathological states.

The coagulation benefits of vitamin K1 are well known, however, the other congeners of the vitamin series are not as common (K2, K3, and K4), but equally contribute to a healthy disposition.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.

In this application note, the charge variant characterisation of an IgG4-based mAb was performed using a BioPro IEX QF anion exchange column coupled to an MS detector.

Discover how the HC-75 series uses a ligand exchange mechanism in order to interact more or less strongly with the analytes of interest.

Hamilton's PRP-C18 column gave good separation with various gradient profiles and under various particle sizes. The excellent loading capacity of the column make this stationary phase desirable.

Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.

GC headspace analysis is commonly used to control volatile organic components in APIs. Methods are specified in U.S. Pharmacopeia General Chapter <467>.

Mesylate and besylate are potentially genotoxic impurities in pharmaceuticals. This app note introduces analysis of sulfonic acid esters utilizing Shimadzu's GCMS-QP.

Nexera Prep with LCMS-2050 and Open Solution software provide a seamless workflow for drug discovery from screening to purification and purity check.

Untargeted comparison of flavour profiles of popular brand soft drinks using immersive sorptive extraction, GCxGC–TOF-MS and chemometrics.

Characterising various petrochemicals – diesel, crude oil and vacuum gas oil – using the enhanced peak capacity of GC×GC-FID with SepSolve’s new thermal modulator.

Some nitrosamine compounds are classified as probably carcinogenic to humans. This application note describes the analysis of six nitrosamines by LC–MS/MS.

Shimadzu provides a number of solutions for the analysis of impurities in pharmaceutical products, as described in this Application Notebook.

USP General Chapter <1469> ensures appropriate control of NSAs in drug products. This application replicates NSA determination in APIs using Shimadzu's GCMS-TQ8050 NX.

This application note describes the efficient development of robust analytical methods based on Analytical Quality by Design (AQbD) for small-molecule drugs.

This demonstrates how to perform cannabis potency analysis using HPLC-UV, displaying the advantages of this technique for analyzing acidic cannabinoids.