Application Notes: General

The measurement of adenosine nucleotides represents important diagnostic measures concerning metabolic standing for the determination of various pathological states.

The coagulation benefits of vitamin K1 are well known, however, the other congeners of the vitamin series are not as common (K2, K3, and K4), but equally contribute to a healthy disposition.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.

In this application note, the charge variant characterisation of an IgG4-based mAb was performed using a BioPro IEX QF anion exchange column coupled to an MS detector.

Discover how the HC-75 series uses a ligand exchange mechanism in order to interact more or less strongly with the analytes of interest.

Hamilton's PRP-C18 column gave good separation with various gradient profiles and under various particle sizes. The excellent loading capacity of the column make this stationary phase desirable.

Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.

GC headspace analysis is commonly used to control volatile organic components in APIs. Methods are specified in U.S. Pharmacopeia General Chapter <467>.

Mesylate and besylate are potentially genotoxic impurities in pharmaceuticals. This app note introduces analysis of sulfonic acid esters utilizing Shimadzu's GCMS-QP.

Untargeted comparison of flavour profiles of popular brand soft drinks using immersive sorptive extraction, GCxGC–TOF-MS and chemometrics.

Characterising various petrochemicals – diesel, crude oil and vacuum gas oil – using the enhanced peak capacity of GC×GC-FID with SepSolve’s new thermal modulator.

Some nitrosamine compounds are classified as probably carcinogenic to humans. This application note describes the analysis of six nitrosamines by LC–MS/MS.

Shimadzu provides a number of solutions for the analysis of impurities in pharmaceutical products, as described in this Application Notebook.

USP General Chapter <1469> ensures appropriate control of NSAs in drug products. This application replicates NSA determination in APIs using Shimadzu's GCMS-TQ8050 NX.

This application note describes the efficient development of robust analytical methods based on Analytical Quality by Design (AQbD) for small-molecule drugs.

This demonstrates how to perform cannabis potency analysis using HPLC-UV, displaying the advantages of this technique for analyzing acidic cannabinoids.

Application note shows how thermal desorption GC–MS is used to monitor the release of PFAS during the application of aqueous film-forming foam (AFFF).

Demonstrating how commercially available TD equipment is used to monitor CF4 & other products of incomplete destruction (PIDs) resulting from PFAS removal technologies.

Download our application note to learn how to test for cannabinoids in biological samples and discover a method offering the required sensitivity for drug tests.

This study investigates the performance of a high-throughput automated thermal desorption instrument coupled to GC–MS/MS for PFAS analysis.

This application note utilises SCION's GC-MS to test for cannabinoids, providing method conditions and sample preparation techniques to validate methods.

Measuring PFAS pollution in ambient air with TD–GC–MS/MS at concentrations low as 2 pg/m3. Each of 19 targeted compounds had linear calibration with high repeatability.

This application note provides insights into how to monitor the different cannabis strains, and showcases how the Horwitz ration can be a useful tool in this analysis.

This application note demonstrates the performance of SCION's GC combined with FID, showcasing its higher sample throughput.

Discover how Headspace GC-MS is used to test cannabis samples for residual solvents and pesticides in this application note.

Discover the advantages of using GC-FID for cannabis terpene testing, and see our expert advice on method validation for the technique.

High-quality data is critical in the pharmaceutical industry. Chromatography Data Systems (CDS) are helping organizations ensure data integrity, compliance with regulatory requirements, and the production of safer medicines.