Application Notes: General

In this work we discuss an automatable sample preparation protocol for peptide mapping used in QC, bioprocess, analytical development, and research environments to deliver comprehensive information about the primary structure of biotherapeutic proteins.

In this work we discuss how to achieve complete and clean trypsin digestion with an enzyme that provides a balance of missed cleavage, non-specific cleavage, and trypsin autolysis.

In this work we discuss an automated high-throughput sample preparation method and fast LC-MS peptide mapping for Critical Quality Attribute (CQA) peptide measurement that was developed for low volume and low concentration microbioreactor samples.

This application note demonstrates how splitless micro-furnace pyrolysis increases the sensitivity of microplastic measurements.

Ultrapure water is essential for accurate analyses because as analytical methods become more sensitive, they also become more vulnerable to interference. Maintaining consistently high water quality is crucial for ensuring reproducible results and avoiding the need for time-consuming repeat analyses:

Air quality measurement: Continuous, cryogen-free on-line monitoring of PAMS in ambient air using hydrogen carrier gas using EPA PAMS method.

Tube-based thermal desorption for monitoring chemical warfare agents Malathion, Russian VX and mustard gas at ultratrace levels without degradation or losses.

This app note describes automated, high-performance GC–MS analysis of humid 'air toxics' samples in canisters, using a cryogen-free system for preconcentration and TD.

This application note shows the robust, reproducible analysis of trace VOCs in hydrogen fuel by TD–GC–MS/SCD.

This study investigates the performance of a high-throughput automated thermal desorption instrument coupled to GC–MS/MS for PFAS analysis.

This 9-minute acylcarnitines LC-MS/MS analysis allows testing of 25 underivatized acylcarnitines, including several isobaric compounds for differential diagnosis.

TD–GC–MS analysis of VOCs in air using H2 carrier gas meets all the performance criteria cited in US EPA Method TO-17, including linearity, reproducibility & MDLs.

Analysis of 15 most common sugars in honey within 25 min by HPAEC-PAD using Antec Scientific ALEXYS Carbohydrate Analyzer and SweetSep column.

Across the world, there has been an explosion of scientific discovery. Fueling this progress is a convergence of breakthroughs in biological sciences, automation, data harnessing, computing power, and software infrastructure. These are already driving changes in laboratory architecture, bringing automation and digitization to the fore to connect the physical and cultural attributes of laboratory space and scientific practice.

We present electrical asymmetrical flow field-flow fractionation with multi-angle light scattering (EAF4-MALS) to derive parameters of a liposomal form of doxorubicin.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

A separation of peptides is performed on a HALO 160 Å PCS C18 column showing excellent peak shape under formic acid conditions.

Discover the GC 2400™ Platform for consistent retention times and repeatable, precise sample injections.

Learn more about how the System Monitoring application provides real-time, contextual details for all Empower™ Software-controlled chromatography systems, helping you easily coordinate your laboratory work and respond dynamically to changing priorities.

A separation of antidepressants is compared between a fully porous C18 and the HALO® PCS C18 column.

Discover the results obtained with the PerkinElmer GC 2400™ Platform for the analysis according to USP grade Carbomer 940.

Discover the results obtained with the PerkinElmer GC 2400™ Platform for the analysis according to USP grade Carbomer 940.

A synthetic peptide panel is screened on the HALO® Peptide PCS C18 and compared to a standard peptide C18 stationary phase.

Built upon Fused-Core® technology, the HALO® PCS C18 maintains peak symmetry at high loading capacities and provides alternate selectivity for C18 bonded phases.

Ambient air analysis and study of the new IONICON Fusion PTR-TOF, providing ultrahigh sensitivities up to 80 000 cps/ppbV, high mass resolving power and ppqV detection limit

The new HALO® PCS C18 phase offers an alternative to chromatographic separations.

In a head-to-head SPP comparison of two positively charged C18 surface chemistries, the HALO 90 Å PCS C18 obtains improved resolution, efficiency, and tailing factors.