Application Notes: General

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent analysis according to USP requirements, showing improved productivity and lab time optimization.

Expert insights on purification workflows in pharmaceutical labs, challenges in managing data, and the role of data automation solutions in data analysis and integration.

In this study, a generic, 5-min linear gradient was used to separate six basic drug compounds on a short (50 mm) PRP-C18 column.

Identification of polyphenolic catechin compounds for health and industrial quantification and quality control of tea products.

Nine structurally diverse, strongly basic drug compounds are resolved in less than 2 minutes using a high pH mobile phase and a fast acetonitrile gradient at 80 °C.

The diterpenoid, paclitaxel, is as a potent chemotherapy agent for breast and ovarian cancer. Here, the isolation of paclitaxel from its major impurities is shown.

Chemically resistant resin bed allows for a wide base of mobile phase choices with excellent anion separation

Identifying benzodiazepine metabolites can be highly valuable in detecting abuse. Metabolites of oxazepam are found containing both hydroxyl and glucuronides.

A reversed-phase HPLC method was developed to separate five steroid hormones, with partition coefficients ranging from 1.47 (cortisone) to 4.5 (pregnenolone).

The common artificial sweeteners acesulfame K, saccharin and cyclamate Na were analysed using a YMC-Triart C18 UHPLC column in less than 10 min via MS/MS detection.

This tech note describes a method of continuous monitoring of flow rate to provide real-time validation of the LC system performance, improving reliability of results.

GPC/SEC-viscometry enables measurement of true molar masses for carrageenan and detects subtle differences between samples with similar molar mass distributions.

GPC/SEC-MALLS analysis of hyaluronic acid obtains absolute molar mass while conventional GPC/SEC with concentration detectors only provides apparent molar masses.

This technical overview discusses best handling practices for IVT mRNA and analysis with the Fragment Analyzer systems, including sample handling and quantification tips.

A validated method was developed for screening short to long chain PFAS in industrial water, using direct injection with no sample preparation.

Discover how SEC can be used in biopolymer applications including bioconjugates, proteins, mAbs, mRNA1, viruses, extracellular vesicles, and liposomal nanoparticles.

A multimodal method using HILIC and anion ion exchange chromatography for high peak resolution was developed to separate ultra-short to medium chain PFAS.

Utilizing the Shodex HILIC VT-50 2D, a method was developed on LC–MS to analyze ultra-short chain (C1¬–C4) PFAS though long chain (C8–C10) PFAS.

A validated method was developed for screening short to long chain PFAS in ground water, using direct injection with no sample preparation.

This paper discusses sustainable solutions for size separation of macromolecules that align with the 12 principles of green chemistry.

Tips & Tricks designed to support GPC/SEC users in their daily work, providing comprehensive overviews on different aspects of this powerful technique.

Robust, reliable GPC/SEC analysis of saccharides and polysaccharides can occur with very high resolution using Agilent SUPREMA columns with 3 and 5 µm particles.

Complex food & flavor headspace analysis with the new FUSION PTR-TOF 10k demonstrates benefits of high mass resolving power & extreme sensitivity for fast measurements.

Ion chromatography and mass spectroscopy can be combined to create a powerful analytical technique. Check out this white paper to learn how IC-MS was used for the straightforward ID and quantification of organic acids and inorganic anions in one run.

The UK's life sciences prowess and ambition to become a 'science superpower' rely on the continuous supply of highly specialised lab space. However, we are currently facing a national challenge, with lab space critically low in abundance. The question is, how do we fix this problem?

Fast and sensitive analysis of lactose and isomers in ‘lactose-free’ labelled products using Antec Scientific new SweetSep™ AEX200 HPAEC column.