Application Notes

Articles

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.


Analysis of Gamma-Hydroxybutyrate (GHB) in Whole Blood Using Quicker SPE and LC-MS/MS v2

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

Pain Relievers from Plasma Using Rapid SPE Products v2

A sensitive method for analyzing nicotine and metabolites using SLE to increase recoveries, while still displaying accuracy, precision and linearity.


A Sensitive Extraction Method for Nicotine and Metabolites from Urine using SLE

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Utilizing a Rapid, Two-Step Method for the Clean-Up of Veterinary Drugs in Milk Using Strata®-X PRO Solid Phase Extraction (SPE) v2

Peptides are extracted from plasma comparing Strata-X PRO SPE to two types of ion exchange polymeric sorbent. Strata-X PRO provides high recoveries with a fast and effective clean-up method.

High Recovery of Peptides from Plasma Using Different SPE Sorbents v2

Revolutionize your bioanalytical sample preparation. Search application notes by your compounds of interest, application area, SOLA chemistry phases, or SOLA formats.

SOLA Solid-Phase Extraction Application Compendium

Simplify coupling the µPAC™ column to the emitter. Only 2 connections, an integrated liquid junction and grounding point for robust, low dispersion nanoLCMS interfacing.

µPAC™ Flex iON Connect ESI-MS interface

This application note provides an optimised and validated fully automated sample preparation and LC–MS/MS analysis solution for seven target nitrosamines in two classes of drug substance.


Fully Automated Solution for Nitrosamines Analysis 

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Method Validation for Atrazine Analysis

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

Application Notes: LC-MS