Application Notes: LC-MS

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Expert insights on purification workflows in pharmaceutical labs, challenges in managing data and the role of data automation solutions in data analysis and integration

In this application note we outline some characteristics of automatable tasks on analytical data and give customer workflow examples to inspire your own ideas.

This 9-minute acylcarnitines LC-MS/MS analysis allows testing of 25 underivatized acylcarnitines, including several isobaric compounds for differential diagnosis.

A separation of peptides is performed on a HALO 160 Å PCS C18 column showing excellent peak shape under formic acid conditions.

Expert insights on purification workflows in pharmaceutical labs, challenges in managing data, and the role of data automation solutions in data analysis and integration.

The common artificial sweeteners acesulfame K, saccharin and cyclamate Na were analysed using a YMC-Triart C18 UHPLC column in less than 10 min via MS/MS detection.

A validated method was developed for screening short to long chain PFAS in industrial water, using direct injection with no sample preparation.

A multimodal method using HILIC and anion ion exchange chromatography for high peak resolution was developed to separate ultra-short to medium chain PFAS.

A validated method was developed for screening short to long chain PFAS in ground water, using direct injection with no sample preparation.

This application note outlines a QuEChERS method for the simultaneous analysis of cannabis for 67 pesticides and 5 mycotoxins residues in cannabis flower.

This application note explains how the Mnova automation solution enables you to streamline the reaction optimization process.

This article explores how to use this powerful, free, simulation tool to simplify and speed up LC–MS/MS method development.

Xylazine has emerged as a prevalent adulterant in illicit drugs. A robust SPE and LC-MS/MS method for analyzing xylazine, fentanyl, and other adulterants is presented.

SweetSep is a new line of HPAEC columns from Antec Scientific for superior separation of all classes of carbohydrates including N-glycans using PAD or MS detection.

This application note describes how Dow AgroSciences created efficiency in method development by incorporating method development software into their best practices.

Improved and universal subunits LC–MS analysis of multiple classes of monoclonal antibodies using in-line electrochemical reduction  

Here we introduce LC/MS analysis methods using the Shodex™ HILICpak™ VC-50 2D column for various cationic neurotransmitters.

The HILICpak™ VG-50 series columns are able to achieve high recovery rates of saccharides, organic acids, and amino acids.

Mucopolysaccharidosis and oligosaccharidosis are LSDs caused by enzyme deficiencies. Early diagnosis is key using chromatographic separation and MS/MS identification.

Demonstration of the sensitivity gain for the Pierce peptide mix, which is achieved when using UHPLC columns of different i.d.s, as well as a micro-LC approach.

Reversed-phase LC–MS analysis of two phospholipids—LPC (16:0) and PC (34:2)—using a bioinert coated column in comparison with a regular stainless steel one.

This application note presents a side-by-side comparison of the AdvanceBio and GlycoWorks kits for the preparation and analysis of released N-glycans.

This app note demonstrates the excellent performance of mediterranea sea18 for MMA, MCA, and HCyr quantification by LC–MS for second tier tests in newborn screening.

This application analyzes saccharides, organic acids, and amino acids using a Shodex™ HILICpak™ VG-50 2D column, with LC–MS alkaline gradient conditions.

The new Ascentis® Express PFAS HPLC and delay columns allow the highly efficient separation of 33 PFAS compounds in 5 minutes with reduced background contamination.

Go ahead, take the stress out of your LC method transfer journey with our free master guide. Features a compilation of proven techniques to help you succeed.