Application Notes: LC-MS

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In-Depth Label-free analysis of single mammalian cells with nanodroplet single processing

This document reveals integration of LC-MS with an on-line advanced mass spectral database to enable faster development of acquisition methods.

This App Note discusses ultra-sensitive quantification of antibody biotherapeutics and biomarkers with a novel trapping-microLC-FAIMS/SRM-MS strategy.

In this new infographic, discover optimized workflows utilizing leading Thermo ScientificTM instruments, consumables, and software for AAV product and process characterization.

App Note discusses improving the limit of quantification of sulfonamides in complex meat muscle extract by incorporating FAIMS technology into the LC/MS workflow.

This technical note provides discovery to quantitation workflows for COVID-19-infected individuals by monitoring two biological matrices – plasma and nasopharyngeal swab

Developing an analytical method that merges 3 conventional LC-UV methods into 1 LC-MS/MS method, improving laboratory productivity while maintaining high data confidence.

This Tech Note evaluates data-independent acquisition performance on the Thermo Scientific™ Orbitrap Exploris™ 240 MS for quantitative discovery proteomics analysis.

This application note covers a non-derivatization LC–MS/MS method for determining total proteinogenic amino acids and taurine amounts in infant/adult milk formulas.

This application note covers the use of a method package to assess the safety level of several meat samples, eggs, and milk.

In this application note, an HPLC with MWD detection method is detailed to detect parabens in cosmetic and personal care products.

This application note will describe a rapid LC–MS/MS method for the separation and detection of 44 drug of abuse compounds in urine samples.

Method for complete, accurate quantification of vitamin E acetate by LC–MS/MS in less than three min, utilizing a PerkinElmer QSight® 420 triple quadrupole system

Effective, robust online SPE sample loading and chromatographic separation/quantitation of mycotoxins, using QSight SP50 online SPE system with a QSight 210 MS/MS detector.

This application note demonstrates a simple, fast, and robust green chemistry method for the accurate quantitation of six additives in diet soft drinks.

Rapid, simple LC method for the analysis of six common VOC metabolites in urine for monitoring occupational exposure to the VOCs styrene, toluene, xylene, and ethylbenzene.

In this work, an LC–MS/MS method is presented for the analysis of 66 pesticides and five mycotoxins in cannabis and hemp concentrate.

This validation study demonstrates the use of the QSight® tandem quadrupole mass spectrometer (LC–MS/MS) for the application of PFAS EPA Method 537.1 in drinking water.

LC–MS workflow for accurate quantification/detection of individual host cell proteins, from sample preparation to the reporting of values of process-related impurities.

Efficient and accurate HPLC analysis of lamotrigine in compliance with USP

USP-compliant assay analysis of hydrocortisone using a PerkinElmer LC 300 HPLC System

Efficient and compliant HPLC analysis of pregabalin

Determination of four complex carbohydrates utilizing a PerkinElmer LC 300 HPLC System, a hydrophilic interaction chromatography (HILIC) technique

HPLC method for saccharide content determination via method CRA SACCH.03 through the analysis of nine commercially available high fructose corn syrups

A review of considerations when optimizing high-throughput methods and achieving fast analyses on Avantor® ACE® HTP-MS columns with examples of key LC–MS separations.

Determination of 16 common cannabinoids utilizing a PerkinElmer LC 300 HPLC System