Application Notes: LC-MS

The analysis of human plasma samples using a bioinert coated YMC Accura Triart C8 column demonstrates that real-life lipidomic analysis in under 10 minutes is possible.

The analysis of 3 different RNA and DNA oligonucleotide mixtures demonstrates the supremacy of the bioinert coated YMC Accura Triart Diol-HILIC columns.

Measuring ultrashort-chain PFAS (C1-C4) in water is crucial due to their ubiquity and potential human exposure. Standard RPLC tests struggle with these compounds.

Crucial phosphorylated compounds can be analyzed by a polymeric iHILIC-(P) Classic HILIC column and MS. The method is applicable for targeted and non-targeted metabolomics.

In this short note, we will consider the selection of LC procedures to separate diniconazol enantiomers and show how data automation improves the process.

This application note discusses how to streamline method transfer outcomes using ACD/Labs' method development software, Method Selection Suite.

This application note demonstrates a novel composite technology that enhances reproducibility of solid phase extraction compared to a traditional loose packed format.

This app note outlines SPE extraction of water samples following EPA Draft Method 1634, comparing polymeric HLD SPE cartridges and polymeric HLB SPE cartridges.

In this short note, we will consider the selection of LC procedures to isolate ezetimibe from several of its degradants and show how data automation improves the process.

ZipChip-MS streamlines mAb charge variant characterization, eliminating the need for method development. Data is seamlessly processed in Byos. This note outlines an expeditious workflow for biosimilarity assessment among mAbs.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.

identification and quantification of 34 target PFAS at parts-per-trillion levels in pork, plus retrospective analysis of sample data files for other untargeted PFAS.

This application note outlines a QuEChERS method for the simultaneous analysis of cannabis for 67 pesticide and 5 mycotoxin residues in cannabis flower.

This application note explores the benefits of using LNI lab benches to enhance the performance of LC–MS systems.

This application note emphasizes the assessment criteria and key factors to consider when evaluating and choosing chromatographic methods.

Nexera Prep with LCMS-2050 and Open Solution software provide a seamless workflow for drug discovery from screening to purification and purity check.

Some nitrosamine compounds are classified as probably carcinogenic to humans. This application note describes the analysis of six nitrosamines by LC–MS/MS.

Identifying and Mitigating Contamination Ions in Mass Spectrometry: A Comprehensive Guide

The solvent of choice for scientists involved with trace-level and research and analyses.

Reveal PFAS dark matter using high-resolution ion mobility (HRIM) to enhance existing chromatographic methods and provide richer insights into samples.

Important qualities of mobile phase additives for LC-MS analysis

This application note explains how and what to automate to streamline the reaction optimization process and generate comprehensive results for a full plate in minutes.

Enhance LC-MS sensitivity with purer solvents that provide lower background noise.

Overview of how the solvent packaging can impact solvent quality and performance.

An overview of the untargeted PFAS analysis workflow capabilities within Thermo Scientific Compound Discoverer Software using the Orbitrap Exploris Mass Spectrometer.

SEC is highlighted as a tool for the separation and detection of higher-order structure of single stranded DNA oligonucleotides.

This application note explains how the Mnova automation solution enables you to streamline reaction optimization process from raw data to results and decision-making.