Application Notes: LC-MS

This application note demonstrates robust, sensitive quantitation of 10 nitrosamines, and the use of the LC–SRM-MS method to quantify nitrosamine impurities in metformin.

This application note demonstrates fast, highly sensitive quantitation of nine nitrosamines, and the use of the LC–MS method to measure nitrosamine.

With a new electrochemical cell, complete reduction of inter- and intra-disulfide bonds in mAbs is achieved with superior sequence coverage.

This tech note demonstrates the benefits of single quadrupole mass detection for small protein analysis.

Application guide to PFAS analysis in environmental and food samples, from sample preparation to LC–MS/MS analysis, featuring both validated and exploratory methods.

In a commercial laboratory setting, Strata-X-AW and Gemini 3 µm C18 show excellent precision and recovery in EPA Method 533 for the analysis of PFAS in drinking water.

Strata PFAS (WAX and GCB combined in a single SPE tube) compliant with DOD QSM 5.1, but more accurate, precise, and economical than dual tube or dispersed GCB solutions.

A QuEChERs + SPE sample preparation technique coupled with LC–MS/MS is shown to provide sub-ppb analysis of PFAS in dairy and fish samples.

Validation of a water and wastewater method for the California PFAS panel using SPE (WAX/GCB) preparation and LC–MS/MS analysis with a variable pH LC mobile phase

A municipal wastewater laboratory demonstrates the use of QuEChERs sample preparation techniques to analyze PFAS in sediments at sub ng/g levels.

A wide variety of LC column chemistries were evaluated to demonstrate new chromatographic approaches to complex PFAS analyte lists.

Strata-SDB-L and Luna Omega 1.6 µm PS C18 demonstrate excellent precision and recovery in EPA Method 537.1 for the analysis of PFAS in drinking water.

A novel LC approach to manipulate the chromatography of closely related PFAS analytes to separate co-eluties and avoid matrix interferences.

This application note demonstrates robust and sensitive quantitation of 10 nitrosamines, and the use of the LC–SRM–MS to quantify nitrosamine impurities in metformin.

This application note demonstrates fast, highly sensitive quantitation of nine nitrosamines, and the use of the LC–MS method to measure nitrosamine.

PFAS are an emerging concern to environmental health. This has driven the need to monitor and calls for global regulations to restrict or eliminate them.

See how the µPAC™ capLC LC–MS column can help increase sample throughput, and at the same time maintain the highest separation efficiency and sensitivity.

See how the µPAC™ capLC LC–MS columns can contribute in the characterization of the glycosylation pattern of therapeutic enzymes.

Learn how to simplify the connectivity from your µPAC™ column to your mass spectrometer, with Nanospray Flex source. Only two connections, from column to emitter.

The µPAC™ GEN2 nanoLC columns are specifically designed to further improve your LC–MS results. More IDs and higher reproducibility for more confidence in your data.

The µPAC™ Limited Sample Amount column is designed for ultrahigh sensitive separation performance for the smallest sample amounts, typically less than 20 ng of content.

Learn about the µPAC™ trapping columns, and see how they can help sample preconcentration in nanoLC–MS. Pick your preferred workflow, forward or backflush, and run.

Fortis Technologies has launched a new application note on the analysis of cannabinoids. A sample of twelve cannabinoids was analyzed by LC–MS in 7 minutes.  

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE to provide less background noise.

In this application, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product.

Miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides at 1 fmol/uL using SARS-CoV-2 nucleocapsid protein as a model system.

A quantitative LC–MS/MS method using a room-temperature hydrolysis with an advanced SPE product for the analysis of designer and pharmaceutical benzodiazepines in urine