Application Notes: LC-MS

This application note describes a rapid LC–MS/MS method for the separation and detection of 44 drug of abuse compounds in urine samples.

UniSpray is a novel atmospheric ionization technique that provides increased peak response, enabling ultra-trace detection of PFAS and other contaminants.

This application note features a unique, simple, and robust solid-phase extraction method for cannabinoids in urine followed by analysis by LC–MS/MS.

A novel LC approach to manipulate the chromatography of closely related PFAS analytes to separate co-elutes and avoid matrix interferences.

This note summarises a procedure developed by the US Food and Drug Administration to measure 16 PFAS in food using a QuEChERS sample preparation approach and LC–MS/MS analysis.  

PFAS are known to be persistent in the environment. Detecting low levels of PFAS in drinking water is made easier using an Activated Carbon Delay Column.

The effect of various ion pairing reagents (amines and acidic counterions) on the LC–UV and LC–MS analysis of oligonucleotides (ONs) has been studied.

Use software to deconvolute LC–MS spectra from complex samples and identify unknown components.

With a new electrochemical cell, complete reduction of inter- and intra-disulfide bonds in mAbs is achieved. For cystine knots peptides, the sequence coverage was 100%.

HALO® PFAS and PFAS Delay columns are application verified columns well suited for challenging environmental sample analysis.

High resolution separation of 24 PFAS compounds using the HALO® PFAS Delay column coupled with the HALO® PFAS analytical column.

High throughput analysis of 33 PFAS compounds found across EPA methods 533, 537.1, and 8327 in under 5 minutes.

HALO® PFAS delay and HALO® PFAS analytical columns deliver rugged, reproducible performance for the most challenging environmental sample matrices.

Rapid and high-resolution analysis of PFAS compounds across EPA methods 537.1, 533, and 8327, using the new HALO® PFAS delay and analytical columns.

In this study, we confirm the high selectivity of CPC and its capability to purify a set of key compounds and enrich several minor cannabinoids in a single step.

A well-thought-out and detailed grant proposal is essential to the success of the application. Here are 7 steps in the grant-writing process to help you reach new heights.

HRAM MS that utilizes technology that significantly augments unknown analysis capabilities in MetID, untargeted metabolomics and lipidomics research.

Highly selective and sensitive quantitation of eight nitrosamines in metformin drug products using a single LC-SRM-MS method

Today’s challenges in targeted quantitation involve more than just measuring concentrations of target analytes. Gains in productivity are achieved through new hardware and software features.

This application note demonstrates the use of an LC-MS system test for assessing the expected performance level based on protein digest sample and defined LC-MS PQAs.

Learn how artificial intelligence empowered search transforms your proteomics data processing with Proteome Discoverer software and CHIMERYS search engine.

Now you can measure over 7000 proteins in a 70 min LC separation while using a standard 4D-Proteomics™ approach. Learn more. 

This note reviews the process of extraction of synthetic and naturally occurring cannabinoids in urine using SPE and LC–MS/MS using UCT’s SSHLD extraction cartridge.

Reviews the highly retentive but universal nature of UCT’s polymeric Styre Screen® HLD sorbent for analysis of barbiturates, benzodiazepines, and THC in oral fluid.

This application note demonstrates robust, sensitive quantitation of 10 nitrosamines, and the use of the LC–SRM-MS method to quantify nitrosamine impurities in metformin.

This application note demonstrates fast, highly sensitive quantitation of nine nitrosamines, and the use of the LC–MS method to measure nitrosamine.

With a new electrochemical cell, complete reduction of inter- and intra-disulfide bonds in mAbs is achieved with superior sequence coverage.

This tech note demonstrates the benefits of single quadrupole mass detection for small protein analysis.