Application Notes: LC-MS
DOW Designs Efficiencies into Method Development
This application note describes how Dow AgroSciences created efficiency in method development by incorporating method development software into their best practices.
Improved Sample Prep of mAbs
Improved and universal subunits LC–MS analysis of multiple classes of monoclonal antibodies using in-line electrochemical reduction
Analysis of Δ8 and Δ9 THC Metabolites and Other Cannabinoids in Urine
LC/MS Analysis of Neurotransmitters
Here we introduce LC/MS analysis methods using the Shodex™ HILICpak™ VC-50 2D column for various cationic neurotransmitters.
Simultaneous LC/MS Analysis of Multiple Chemicals
The HILICpak™ VG-50 series columns are able to achieve high recovery rates of saccharides, organic acids, and amino acids.
Mucopolysaccharidosis (MPS) and Oligosaccharidosism
Mucopolysaccharidosis and oligosaccharidosis are LSDs caused by enzyme deficiencies. Early diagnosis is key using chromatographic separation and MS/MS identification.
UHPLC/MicroLC High Sensitivity Analysis of Peptides
Demonstration of the sensitivity gain for the Pierce peptide mix, which is achieved when using UHPLC columns of different i.d.s, as well as a micro-LC approach.
UHPLC-MS of Phospholipids Using Bioinert Columns
Reversed-phase LC–MS analysis of two phospholipids—LPC (16:0) and PC (34:2)—using a bioinert coated column in comparison with a regular stainless steel one.
Comparative Analysis of N-Glycan Sample Preparation Kits
This application note presents a side-by-side comparison of the AdvanceBio and GlycoWorks kits for the preparation and analysis of released N-glycans.
Testing MMA, MCA, and HCyr in Dry Blood
This app note demonstrates the excellent performance of mediterranea sea18 for MMA, MCA, and HCyr quantification by LC–MS for second tier tests in newborn screening.