Application Notes: LC-MS

Mucopolysaccharidosis and oligosaccharidosis are LSDs caused by enzyme deficiencies. Early diagnosis is key using chromatographic separation and MS/MS identification.

Demonstration of the sensitivity gain for the Pierce peptide mix, which is achieved when using UHPLC columns of different i.d.s, as well as a micro-LC approach.

Reversed-phase LC–MS analysis of two phospholipids—LPC (16:0) and PC (34:2)—using a bioinert coated column in comparison with a regular stainless steel one.

This application note presents a side-by-side comparison of the AdvanceBio and GlycoWorks kits for the preparation and analysis of released N-glycans.

This app note demonstrates the excellent performance of mediterranea sea18 for MMA, MCA, and HCyr quantification by LC–MS for second tier tests in newborn screening.

This application analyzes saccharides, organic acids, and amino acids using a Shodex™ HILICpak™ VG-50 2D column, with LC–MS alkaline gradient conditions.

The new Ascentis® Express PFAS HPLC and delay columns allow the highly efficient separation of 33 PFAS compounds in 5 minutes with reduced background contamination.

Go ahead, take the stress out of your LC method transfer journey with our free master guide. Features a compilation of proven techniques to help you succeed.

Learn how to transfer your LC methods the right way. A short case study with helpful guidance on how to transfer compendial methods, without needing revalidation.  

This application note provides a reliable HPLC method for profiling PS80 samples to help you maintain drug consistency and quality across every production batch.

This fast, simple LC-MS/MS workflow for the direct analysis of polar pesticides in spinach provides good retention and peak shape over hundreds of matrix injections.

Application guide to advanced sample preparation for chromatography analysis and mass spectrometry techniques for PFAS's more difficult matrices.

Laboratory productivity increase is demonstrated using an SDVB polymer SPE and C18 column selectivity.

Multiple laboratories applied method EPA 537.1 and 533 for the extraction of PFAS in pristine non-potable water and source water assessment.

PFAS experts provide insight on workflow considerations on how to manage and prevent cross-contamination to ensure quality analysis.

In metabolomics analysis, the use of a biocompatible LC system has significant advantages over a stainless steel LC, as demonstrated in this application.

FAQ on scope, workflow, timeline, requirements for the Fith Unregulated Contaminants Monitoring Rule (UMCR 5)

Analysis of HFPO-DA in a multi-residue method along with 24 other common PFAS

Benzodiazepines are depressants and used to relieve anxiety, insomnia, and more. This app note discusses a urine extraction to confirm the presence of benzodiazepines.

A rapid and simple LC method for the analysis of six common VOC metabolites in urine for monitoring occupational exposure to VOCs.

A fully validated method for the determination of twelve mycotoxins in various food matrices by stable isotope dilution QSight LC–MS/MS.  

A fast, direct method for LC–MS/MS analysis of amino acids in plasma was developed during the course of this study.  

This application note shows a micro-flow LC–MS method developed on the Thermo Scientific Vanquish Neo UHPLC system is suitable for high-throughput proteomic analyses of large sample cohorts.

This application note shows a micro-flow LC–MS method developed on the Thermo Scientific Vanquish Neo UHPLC system is suitable for high-throughput proteomic analyses of large sample cohorts.

This application note reveals the Thermo Scientific Vanquish Neo UHPLC system offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.

This application note reveals the Thermo Scientific Vanquish Neo UHPLC system offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.

This application note demonstrates the seamless method transfer from research and development to QC enabled by the end-to-end MAM 2.0 workflow.