Application Notes: LC-MS

Nitrosamines are potentially dangerous genotoxic compounds that have been recently found within some pharmaceutical products. We demonstrate highly sensitive methods to accurately detect and quantify these compounds.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC–MS/MS for measuring pesticides in spinach purchased from local grocers is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in honey purchased from local apiaries is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in kale purchased from local grocers is described in this application note.

A SLE application for acids (THC-COOH), neutrals (barbiturates), and bases (Norbuprenorphine and Buprenorphine) from a urine matrix containing β-glucuronidase followed by two LC-MS/MS methods.

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE for less background noise and cleaner samples post sample preparation.

This application focuses on developing a rapid SPE and LC-MS/MS method for the quantitative analysis of uracil and its two homologues from human serum

Testosterone was isolated from plasma using Novum PRO 96-Well Plates SLE sample preparation.

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

A sensitive method for analyzing nicotine and metabolites using SLE to increase recoveries, while still displaying accuracy, precision and linearity.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Peptides are extracted from plasma comparing Strata-X PRO SPE to two types of ion exchange polymeric sorbent. Strata-X PRO provides high recoveries with a fast and effective clean-up method.

Revolutionize your bioanalytical sample preparation. Search application notes by your compounds of interest, application area, SOLA chemistry phases, or SOLA formats.

Simplify coupling the µPAC™ column to the emitter. Only 2 connections, an integrated liquid junction and grounding point for robust, low dispersion nanoLCMS interfacing.

This application note provides an optimised and validated fully automated sample preparation and LC–MS/MS analysis solution for seven target nitrosamines in two classes of drug substance.

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

This work is focused on the development of a novel SARS-CoV-2 spike glycoprotein assay based on BAMS™ assay platform with detection by MALDI-TOF MS.

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

Reveal more veterinary drugs in Food. Use the QSight LC–MS/MS to get a fast, selective, and sensitive method for the determination of sulfonamide antibiotics in milk.

HALO® PFAS delay and HALO® PFAS analytical columns deliver rugged, reproducible performance for the most challenging environmental sample matrices.

To improve the chromatography of PFAS and other environmentally concerning chemicals, application-assured HPLC columns have been developed to deliver high efficiency and robust analysis.

This application demonstrates the capability of the HALO® PFAS columns for separating branched and linear isomers of PFAS species PFHxS, found in well water.

High throughput analysis of 33 PFAS compounds found across EPA methods 533, 537.1, and 8327 in under 5 minutes.

High resolution separation of 24 PFAS compounds using the HALO® PFAS Delay column coupled with the HALO® PFAS analytical column.

Rapid and high-resolution analysis of PFAS compounds across EPA methods 537.1, 533, and 8327, using the new HALO® PFAS delay and analytical columns.

To improve the chromatography of PFAS and other environmentally concerning chemicals, application-assured HPLC columns deliver high efficiency and robust analysis.

In this application note high resolution SCX was coupled directly to an ultrasensitive online native MS using YMC’s BioPro IEX SF to analyse mAb charge variants.