Using oral fluid as the matrix, a viable and simple solid phase extraction method for a wide range of drugs is developed. Several oral fluid collection devices were evaluated to determine the effectiveness of the cleanup procedure, ultimately confirming that the method is both robust and widely applicable.
An ultra-sensitive sample preparation technique using solid phase extraction (SPE) microelution 96-well plates effectively concentrates peptides and allows for cleanup of small volume.
A suite of unknown drug compounds from whole blood are analyzed by LC–MS-MS, requiring the need for an effective yet nonspecific cleanup technique. The resulting method demonstrates a simple and fast sample preparation procedure that is suitable for screening many compounds.
A suite of unknown drug compounds from whole blood are analyzed by LC–MS-MS, requiring the need for an effective yet nonspecific cleanup technique. The resulting method demonstrates a simple and fast sample preparation procedure that is suitable for screening many compounds.
An ultra-sensitive sample preparation technique using solid phase extraction (SPE) microelution 96-well plates effectively concentrates peptides and allows for cleanup of small volume.
Fast analysis of 14 banned carcinogenic aromatic amines using a Kinetex EVO C18 core-shell HPLC/UHPLC column with narrow peak widths along with excellent resolution between all compounds of interest.
Fast analysis of 14 banned carcinogenic aromatic amines using a Kinetex EVO C18 core-shell HPLC/UHPLC column with narrow peak widths along with excellent resolution between all compounds of interest.
Better detection, separation, and ionization of cannabinoids by a high pH LC/MS method method that utilizes a high performance Kinetex EVO C18 column.
Quantitative method to accurately monitor paraben levels in food and other personal care products using Novum Simplified Liquid Extraction (SLE) products in conjunction with a Kinetex EVO C18 5 μm core-shell HPLC column.
Better detection, separation, and ionization of cannabinoids by a high pH LC/MS method method that utilizes a high performance Kinetex EVO C18 column.
Quantitative method to accurately monitor paraben levels in food and other personal care products using Novum Simplified Liquid Extraction (SLE) products in conjunction with a Kinetex EVO C18 5 μm core-shell HPLC column.
A method is illustrated for the simultaneous analysis of nicotine, anabasine, and three of nicotine’s major metabolites (cotinine, nornicotine, and 3-hydroxycotinine) using the Kinetex 2.6 μm EVO C18 column.
Better identification and quantitation of low level peptides utilizing the powerful combination of unique selectivity and core-shell performance gains found with Kinetex EVO C18 core-shell columns.
Better identification and quantitation of low level peptides utilizing the powerful combination of unique selectivity and core-shell performance gains found with Kinetex EVO C18 core-shell columns.
A method is illustrated for the simultaneous analysis of nicotine, anabasine, and three of nicotine’s major metabolites (cotinine, nornicotine, and 3-hydroxycotinine) using the Kinetex 2.6 μm EVO C18 column.
Achieve excellent peak shape and resolution between the broad spectrum antibiotic cefaclor and its degredants using the unique selectivity and high efficiency of a Kinetex EVO C18 core-shell.
Achieve excellent peak shape and resolution between the broad spectrum antibiotic cefaclor and its degredants using the unique selectivity and high efficiency of a Kinetex EVO C18 core-shell.
Rapid and comprehensive resolution of a cold medicine API screen that can easily be implemented on HPLC and UHPLC instrumentation using a high performance core-shell Kinetex 2.6 μm EVO C18 column
Rapid and comprehensive resolution of a cold medicine API screen that can easily be implemented on HPLC and UHPLC instrumentation using a high performance core-shell Kinetex 2.6 μm EVO C18 column
A high performance, pH stable core-shell Kinetex EVO C18 column obtains narrow peak shape and extremely useful resolution for a doxylamine formulation impurity profile.
Highly sensitive and reliable screen of Benzodiazepines, Opiates, Synthetic Opioids, Amphetamines, Analgesics and Illicit Drugs
A high performance, pH stable core-shell Kinetex EVO C18 column obtains narrow peak shape and extremely useful resolution for a doxylamine formulation impurity profile.
Enjoy the unique Kinetex EVO C18 selectivity now in 1.7µm and 2.6µm particle sizes for your UHPLC work. This extremely versatile core-shell phase offers the high performance you crave, a unique all-purpose selectivity, and ruggedness you can depend on.
Enjoy the unique Kinetex EVO C18 selectivity now in 1.7µm and 2.6µm particle sizes for your UHPLC work. This extremely versatile core-shell phase offers the high performance you crave, a unique all-purpose selectivity, and ruggedness you can depend on.
Highly sensitive and reliable screen of Benzodiazepines, Opiates, Synthetic Opioids, Amphetamines, Analgesics and Illicit Drugs
The global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population.
Cooking at high temperatures causes a chemical reaction between certain sugars and asparagine which causes acrylamide formation. In this technical note, we explore how to use Novum™ SLE tubes to clean up a coffee matrix in order to quantitate known acrylamide levels. The recovery is especially significant when you consider the polar nature of the acrylamide (LogP -0.27). In addition to high recoveries (>90 %), the low values for the standard deviation and %CV indicates method reproducibility.
Cooking at high temperatures causes a chemical reaction between certain sugars and asparagine which causes acrylamide formation. In this technical note, we explore how to use Novum™ SLE tubes to clean up a coffee matrix in order to quantitate known acrylamide levels. The recovery is especially significant when you consider the polar nature of the acrylamide (LogP -0.27). In addition to high recoveries (>90 %), the low values for the standard deviation and %CV indicates method reproducibility.
Diesel range organic (DRO) compounds have boiling points similar to diesel fuel (C10–C28), ranging from 170–430 ?C. These heavy compounds are amenable to GC-FID analysis; however, important considerations should be taken to ensure reproducible results over repeated injections.
Heterocyclic amines (HCAs) are a class of compounds that are formed when amino acids from meat proteins react with glucose and creatine under high-temperatures, as is associated with frying or grilling over an open flame (1–3). Studies have correlated the consumption of high levels of HCAs with an increased risk of some forms of cancer.
