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Click the title above to open The Column August 22, 2016 Europe & Asia issue, Volume 12, Number 15, in an interactive PDF format.

Click the title above to open The Column August 22, 2016 North American issue, Volume 12, Number 15, in an interactive PDF format.

Continuing MilliporeSigma’s series of podcasts on the impact of water quality on chromatography techniques, Joe Plurad discusses the practical effects of ultrapure water in a specific area of analysis: The importance of water quality on perchlorate analysis by ion chromatography (IC).

I’ve done that thing where I’ve stated a very interesting title-I hope I can deliver something which lives up to it. I dislike it when people “overstate” their talk or poster titles at conferences to draw me in and then don’t deliver against the promise-I’ll let you judge how we go here.

The 33rd International Symposium on Microscale Separations and Bioanalysis (MSB 2017) will be held from 26–29 March 2017, at Conference Center de Leeuwenhorst, The Netherlands, in the “largest flower garden of Europe” near to Amsterdam International Airport and North Sea beaches.

Top-down protein quantitation, especially using triple-quadrupole MS, but even in general, has hardly been pursued. To help fill this gap, we recently reported a systematic investigation of intact-protein quantitation using multiple reaction monitoring (MRM) on a triple-quadrupole MS system, and we believe that this approach can be a promising alternative route to consider going forward.

A group of researchers has studied the migration of monomers and plastic additives from plastic food packaging in microwave heated homemade food and packed liquid food using QuEChERS and gas chromatography coupled to mass spectrometry.

Sciex has announced that it will work with the Francis Crick Institute and the University of Cambridge to build a metabolism-centric proteomic map.

Polymer Char are holding a “User Training Meeting” at the 6th International Conference on Polyolefin Characterization (ICPC), Shanghai, China, 6–9 November 2016.

A publication in TrAC Trends in Analytical Chemistry has covered the recent advances in microfluidic liquid chromatography.

Victor U. Weiss and Günter Allmaier from TU Vien discuss how combining molecular beacons with chip capillary electrophoresis (CE) offers scope to investigate viral RNA replication and improve gene therapy delivery systems.

Doping and cheating the competition may be as old as competition itself. Doping horses for chariot racing was reported during the Roman Empire and doping is now commonly reported in the press. Advanced technologies such as ultrahigh-pressure liquid chromatography (UHPLC) analysis coupled to ultrafast tandem mass spectrometry (MS/MS) detection provide excellent sensitivity for the analysis of horse doping agents.

A preview of the upcoming 31st International Symposium on Chromatography (ISC 2016), which will be held 28 August–1 September at University College Cork, Ireland.

Click the title above to open The Column August 08, 2016 Europe & Asia issue, Volume 12, Number 14, in an interactive PDF format.

Click the title above to open the LCGC North America August 2016 Annual Industry Trends and Directory Supplement, Vol 34 No s8, in an interactive PDF format.

How to optimize the key variables in HPLC analysis-sample preparation and column selection

Systematic toxicological analysis (STA) is an important step in medicolegal investigations of death, poisoning, and drug use. The primary goal is the detection and confirmation of potentially toxic compounds in evidence. This article describes a workflow using non-targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) for reliable compound identification. Tandem mass spectrometry was performed on a low-resolution quadrupole-quadrupole-linear ion trap instrument. Acquired spectra were submitted to automated library search, and positive matches were verified by expert reviewing. After validation, the non-targeted LC–MS/MS technique was integrated in the STA service provided by our laboratory.

Detectors based on ultraviolet absorbance are the most common detectors in use for liquid chromatography.

The past couple instalments of “Sample Preparation Perspectives” have looked at current trends in the field. Another recent trend is dried blood spot analysis and other analysis methods using minute sample amounts. This month we take a quick look at the role of sample homogeneity and the determination of sample size. Microsampling approaches, including dried blood spots, are discussed.

A selection of profiles on leading separation science companies.

As Klaus Unger turns 80, we review his contributions to the field.

The future of biological and clinical research will depend on technological innovations and cross discipline cooperation as science seeks a deeper understanding of increasingly complex biological systems. The 2016 recipient of the AES Mid-Career Award, Amy Herr, and her team at the University of California Berkeley have explored these areas using a combination of chemical engineering, mechanical engineering, and electrical engineering with strong foundations in biology, material science, and analytical chemistry to innovate new microfluidic analytical technology. She recently spoke to LCGC about this work.

Click the title above to open the LCGC Europe August 2016 regular issue, Vol 29, No 8, in an interactive PDF format.

Click the title above to open the LCGC North America August 2016 regular issue, Vol 34 No 8, in an interactive PDF format.

Continuing MilliporeSigma’s series of podcasts on the impact of water quality on chromatography techniques, Joe Plurad discusses the practical effects of ultrapure water in a specific area of analysis: The importance of water quality on perchlorate analysis by ion chromatography (IC).

Waters Corporation has announced a collaboration with the Bioprocessing Technology Institute (BTI), a research institute within Singapore’s Agency for Science, Technology, and Research.