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Chris Bevan, the longest serving President of The Chromatographic Society in recent times, is interviewed by another former President of The Chromatographic Society, John Lough, on the evolution of The Chromatographic Society and chromatography in a changing world.

A popular feature of The Chromatographic Society’s Golden Jubilee publication was an article by Waters describing their heritage and setting out their contributions to the development of chromatography. In this special feature, some of the companies who are regular exhibitors at Society events answer questions on the current and future status of chromatography.

The first meeting in The Chromatographic Society’s diamond anniversary year brought together world‑renowned speakers alongside past presidents of the Society, delegates from academia and industry, and scientific instrument and technology companies at the Institute of Engineering and Technology in central London on 22 March 2016. The presentations included discussions on liquid chromatography (LC), supercritical fluid chromatography (SFC), and gas chromatography (GC) from both an academic and industrial perspective - providing excellent insight into the state-of-the-art in these techniques for the delegates.

A recollection of The Chromatographic Society’s medals and medallists over the years.

The Reid International Bioanalytical Forum is a conference geared towards bioanalytical scientists. It has a unique philosophy where challenging data is often presented to an audience who are encouraged to engage. This article describes how the meeting series was initiated and developed over the past 40 years and how this philosophy has been embedded into the meeting.

On the occasion of the Golden Jubilee of The Chromatographic Society, Peter Myers wrote “The Future of Chromatography” in The Chromatographic Society’s souvenir brochure. Now Peter revisits his chromatographic crystal ball to review his predictions and deliberate on what the future might now hold for separation scientists.

A look at some of the opportunities ChromSoc currently offers.

A theme for The Chromatographic Society Diamond Jubilee Year is to increase public awareness of chromatography. Often the general public, and even chromatographers themselves, fail to appreciate the importance of chromatography. Here Tony Edge, The Chromatographic Society Vice-President, discusses just how much chromatography underpins everyday life.

W. John Lough from the University of Sunderland, UK, in conversation with (old) friends from academia and industry to celebrate 60 years of advances in chromatography.

This study describes a simple, quick approach for the sampling and analysis of nicotine, impurities, and flavour compounds in e-cigarette vapours. Combining thermal desorption (TD) with gas chromatography–mass spectrometry (GC–MS) analysis results in a versatile screening method for tackling the challenge of regulatory compliance and quality control in this rapidly expanding industry.

Analyzing a broad range of semivolatile environmental pollutants at low levels requires a sensitive detector as well as an inert sample pathway. While semivolatiles analysis by methods such as EPA 8270 and EPA 625 typically does not require reporting sub nanogram-on-column concentrations, the latest generation of sensitive mass spectrometers and inert GC columns and inlet liners allow analysts to take advantage of the benefits of split injection while maintaining standard method reporting limits.

Whole column imaging detection capillary isoelectric focusing (iCIEF) has been recognized as a powerful tool for biopharmaceutical development and quality control. Unlike conventional single point detection capillary electrophoresis (CE) systems, in which light absorbance or emission at a specific point along the separation capillary is monitored, iCIEF detects a line of light that is passed through and radiates from the entire separation capillary. As a result, sequential snapshots of the whole separation capillary at different times are obtained. This allows sample separation and interaction in real time to be observed during electrophoresis, enabling fast analytical method development, high resolution separation, and high sample throughput.

This application note describes the transfer of a conventional LC method for the analysis of antihistaminic drugs from an Agilent 1100 Series Quaternary LC to an Agilent 1260 Infinity II LC, and demonstrates that equivalent results can be obtained.

Proteins - especially monoclonal antibodies (MABs) - have become increasingly important in pharmaceutical work. However, there are some important differences between conventional, chemically-synthesized drugs and proteins. Because of the complex and weak structure of proteins, even a slight change in conditions, such as pH value, temperature, or mechanical stress, may lead to aggregation and a loss of activity or stability.

There has been a significant resurgence in the development of antibody-drug conjugates (ADC) as target-directed therapeutic agents for cancer treatment. Among the factors critical to effective ADC design is the Drug Antibody Ratio (DAR). The DAR describes the degree of drug addition that directly impacts both potency and potential toxicity of the therapeutic, and can have significant effects on properties such as stability and aggregation. Determination of DAR is, therefore, of critical importance in the development of novel ADC therapeutics.

Click the title above to open the LCGC Asia Pacific September 2016 regular issue, Vol 19, No 3, in an interactive PDF format.

Click the title above to open the LCGC Europe September 2016 regular issue, Vol 29, No 9, in an interactive PDF format.

Click the title above to open the LCGC North America September 2016 regular issue, Vol 34 No 9, in an interactive PDF format.

The future of biological and clinical research will depend on technological innovations and cross discipline co-operation as science seeks a deeper understanding of increasingly complex biological systems. The 2016 recipient of the AES Mid-Career Award, Amy Herr, and her team at the University of California, Berkeley, USA, have explored these areas using a combination of chemical engineering, mechanical engineering, and electrical engineering with strong foundations in biology, material science, and analytical chemistry to innovate new microfluidic analytical technology. She recently spoke to LCGC about this work.

Eurofins Scientific has announced the acquisition of Agfirst Bay of Plenty, a fruit maturity testing laboratory in New Zealand. Agfirst Bay of Plenty provides independent kiwifruit maturation sampling and testing services across two facilities in the Bay of Plenty region of New Zealand.

Activated Research Company (ARC), producers of the Polyarc reactor, has announced a new partnership with Wasson-ECE to bring the system to the international market for the first time.

Researchers from the Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the source of toxic emissions within electronic cigarettes (e-cigarettes) using headspace gas chromatography in tandem with mass spectrometry (HS-GC–MS) and high pressure liquid chromatography (HPLC).

Incognito ruminates on the woes associated with connecting liquid chromatography (LC) and gas chromatography (GC) columns correctly, and ponders a future where everything is connecting differently.

Fast protein liquid chromatography (FPLC) and high performance liquid chromatography (HPLC): two liquid chromatographic methods in direct comparison. This article discusses the differences between the two techniques with particular emphasis on the requirements of their respective analytes.