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Ligands capable of undergoing electrostatic interactions can add an extra dimension to separations of ionizable compounds.

Part II of this series on practical perspectives on data integrity focuses on instrument setup, system suitability test samples, and data acquisition.

Tips on how to select a hydrophilic interaction chromatography (HILIC) stationary phase.

The Chromatographic Society and Joint Pharmaceutical Analysis Group have announced a one‑day meeting titled From Cradle to Grave: The Chromatographic (Analytical) Method Life Cycle. The meeting will be held at Burlington House, London, UK, on Thursday 10 May 2018.

Click the title above to open the LCGC Europe April 2018 regular issue, Vol 31, No 4, in an interactive PDF format.

Click the title above to open the LCGC North America April 2018 regular issue, Vol 36 No 4, in an interactive PDF format.

Our new sister publication, Cannabis Science and Technology (CST), launched in March 2018.

This article introduces the development of an automated and versatile technique for solution viscosity determination of a wide range of polymeric materials in different solvents.

Click the title above to open The Column March 2018 Europe & Asia issue, Volume 14, Number 3, in an interactive PDF format.

Click the title above to open The Column March 2018 North American issue, Volume 14, Number 3, in an interactive PDF format.

The overriding majority of articles on problems with the technical transfer of HPLC methods ultimately focus on differences between HPLC dwell volumes. However, as the title suggests, there are many more issues which can cause problems in the transfer of HPLC methods, and I wanted to highlight some common issues that come across my desk, in the hope that it will help you avoid these problems in your own practice.

Agilent Technologies has signed a definitive agreement to acquire privately held Advanced Analytical Technologies, Inc.

Several years ago, I would have held the stance that environmental analysis was fairly boring. How complicated can water be? I am not ashamed to say that was a naïve view. It is clear from our research and related research by others on similar topics that much more work in these areas is needed. Standard methods cannot solely accommodate the growing list of targets and the multitude of unknowns associated with complex samples taken from the interface between the petroleum industry and the environment.

A novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.

Novel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.

A fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.

High Throughput Sample Preparation Method for Drugs of Abuse in Urine

Click the title above to open the LCGC Europe March 2018 supplement, Vol 31, No s3, in an interactive PDF format.

An excerpt from LCGC’s e-learning tutorial on optimizing size-exclusion chromatography (SEC) for biologics analysis at CHROMacademy.com

The last decade has witnessed how liquid chromatography columns and instruments changed from long bulky columns with relatively large fully porous particles operated at modest pressures (100Ð200 bar), to short compact columns with small superficially porous particles operated at ultrahigh pressures (1200Ð1500 bar). This (r)evolution has resulted in a tremendous increase in achievable separation performance or decrease in analysis time, but requires a good knowledge of optimal chromatographic conditions for each separation problem and, concomitant, the right instrument configuration.

Is that peak “pure”? How do I know if there might be something hiding under there?

Gas chromatography makes use of a wide variety of detection methods. In addition to the most often used flame-ionization detection (FID), electron-capture detection (ECD), thermal conductivity detection (TCD), and mass-selective detection (MSD), the list of other detection methods is long. They really shine when deployed properly, but their properties and applications can be a bewildering alphabet soup. This instalment presents a compendium of gas chromatography (GC) detection methods, both past and vanished as well as those that are current and relevant to today’s separation challenges.

A snapshot of key trends and developments in the chromatography sector according to selected panelists from companies exhibiting at Analytica 2018.

A snapshot of key trends and developments in the sample preparation sector according to selected panelists from companies exhibiting at Analytica 2018.

A snapshot of key trends and developments in the GC/GC–MS sector according to selected panelists from companies exhibiting at Analytica 2018.

A snapshot of key trends and developments in the data handling sector according to selected panelists from companies exhibiting at Analytica 2018.

Incognito demands that we aim high when presenting our work on chromatography.