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In GC split injection systems as much as 99% or more of the injected sample never enters the column: It is released downstream of the inlet where it can encounter and possibly perturb precision gas control devices. The split-vent trap acts to prevent or at least moderate such effects. This month’s instalment addresses the operation and maintenance of split-vent traps.

LC–MS in Metabolomics

In this video, Robert T. Kennedy of the University of Michigan discusses the role of liquid chromatography–mass spectrometry (LC–MS) in the rapid development of metabolomics and the challenge of dealing with all the data. He then goes onto talk about the methods used in a recent study on glucose metabolism to analyze complex metabolic pathways and the challenges of using smaller samples.

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A team of scientists has analyzed and evaluated the impact of salt weathering on an historical house using a combination of ion chromatography (IC), chemometrics, and thermodynamic chemical modelling.

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Microbial life is possible within the Earth’s mantle, according to new research. High performance liquid chromatography–mass spectrometry (HPLC–MS) analysis of rock cores sampled from the Iberian plate margin (off the coast of Spain and Portugal) revealed the presence of lipid biomarkers indicative of microbial communities present beneath the seafloor more than 100 million years ago.

Agilent Technologies Inc. (Santa Clara, California) has agreed to support research by Steven Gross, a faculty member in the Department of Pharmacology at Weill Cornell Medical College (New York, New York), into amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

Purnendu “Sandy” Dasgupta, Hamish Small Chair in Ion Analysis of Chemistry and Biochemistry in the UT Arlington College of Science, has been awarded almost $1 million from NASA. The grant will support research into extension of the open-tubular capillary chromatography platform that Dasgupta developed for the detection and separation of ions.

In this video from LCGC TV, Mary J. Wirth of Purdue University explains the phenomenon of slip flow: what it is, how it can improve separations - particularly of proteins and monoclonal antibodies - and where it may take us in the future.

Agilent Technologies Inc. (Santa Clara, California) and Seahorse Bioscience (Billerica, Massachusetts) have signed a definitive agreement under which Agilent will acquire Seahorse Bioscience, a provider of instruments and assay kits for measuring cell metabolism and bioenergetics.

There is a shortcoming in our current educational system. There is too much rote learning, and not enough time given to let science-minded students explore a topic. Overall, when students ask their own questions (not ones given to them by instructors), they become more invested in finding the answers.