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No matter where you live or who you work for, you’re likely to encounter one or more of these liquid chromatography (LC) column problems at some point.

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Ion-mobility spectrometry (IMS) is an analytical technique that provides for the separation of ions in the gas phase. The separation, occuring on a timescale of milliseconds, is based on the differing mobility of ions according to their charge, shape, and size. These characteristics make IMS suitable for coupling with mass spectrometry (MS), to serve in current MS-based workflows for metabolomics and lipidomics. IMS–MS improves peak capacity and signal-to-noise ratios, and it provides more confidence during compound identification or confirmation than conventional analyses.

No matter where you live or who you work for, you’re likely to encounter one or more of these liquid chromatography (LC) column problems at some point.

The 42nd International Symposium of High Performance Liquid Phase Separations and Related Techniques (HPLC 2015), chaired by Gérard Hopfgartner was held 21–25 June in Geneva, Switzerland. This instalment covers some of the highlights observed at the symposium including stationary-phase developments, particle technology, and areas of growing application of HPLC. In addition, trends and perspectives on future developments in HPLC culled from the conference are presented.

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As flame ionization detection (FID) approaches its 60th anniversary in 2017, this instalment examines the crucial role that it has played and continues to play for all types of gas chromatography (GC). Without FID, the early development of GC would have proceeded more slowly, especially in the petroleum industry and related hydrocarbon application areas.

Ion-mobility spectrometry (IMS) is an analytical technique that provides for the separation of ions in the gas phase. The separation, occuring on a timescale of milliseconds, is based on the differing mobility of ions according to their charge, shape, and size. These characteristics make IMS suitable for coupling with mass spectrometry (MS), to serve in current MS-based workflows for metabolomics and lipidomics. IMS–MS improves peak capacity and signal-to-noise ratios, and it provides more confidence during compound identification or confirmation than conventional analyses.

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LCGC TV: Luigi Mondello on the Fundamentals of 2D LC Comprehensive liquid chromatography (LC) is a multidimensional technique that has the potential to increase peak capacity resolution when separating complex mixtures, especially in food analysis.

Seven outdated traditional practices that should not be performed without considering alternative approaches that can improve results, provide lower operation costs, or give faster run times. Instead of working harder, analytical scientists should work smarter. Learn more by clicking through the slideshow.

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Laser irradiation of blue tattoo ink can create toxic byproducts - including hydrogen cyanide (HCN) - according to new research published by scientists at the German Federal Institute for Risk Assessment. Pyrolysis gas chromatography–mass spectrometry (Py–GC–MS) was performed on samples of copper phthalocyanine blue to predict the decomposition products resulting from irradiation, as part of a wider on-going project assessing the safety of tattoo inks.