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Gain an invaluable insight into the key methods that are used for biomolecule characterization, process control, and release testing

How to distinguish between LC column overload and detector overload.

What exactly is SFC? Although you may have heard and read much about it recently, it is still rather vague to many a chromatographer.

Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh-Dyer and Folch lipid extraction methods from the late 1950s. This month we will take a look at the lasting impact of these papers and explore the current state of lipid extractions, including lipidomics.

A memoir of Phyllis Brown-a pioneering chromatographer, a devoted mentor, and a champion for women in science

How to distinguish between liquid chromatography (LC) column overload and detector overload.

There has been a revival of supercritical fluid chromatography (SFC) in recent years, especially in the chiral preparative field, but also more recently in the analytical area. However, SFC is considerably more complex than liquid chromatography (LC), mainly because of the compressibility of the mobile phase. One can say that SFC is a “rubber variant” of LC where everything considered constant in LC varies in SFC. In this review, we go through advances in theory, instrumentation, and novel applications.

Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh-Dyer and Folch lipid extraction methods from the late 1950s. This month we take a look at the lasting impact of these publications and explore the current state of lipid extractions, including lipidomics.

The PEFTEC International Conference and Exhibition for Petroleum, Refining, and Environmental Analysis will be held on 18–19 November 2015 at the Antwerp Exhibition Centre, Antwerp, Belgium

Agilent Technologies Inc. has announced that Dr. Lawrence J. Lesko from the University of Florida’s College of Pharmacy in Orlando, USA, has received an Agilent Thought Leader Award for his research into preclinical toxicological assessments of new medicines.

Professor Wolfgang Lindner spoke to LCGC Editorial Advisory Board member Kevin A. Schug about his inspiring and influential career in chromatography.  

Mélisande Bernard is developing chromatographic methods to detect substandard cardiovascular drugs in Africa.

Click the title above to open the LCGC Europe August 2015 regular issue, Vol 28, No 8, in an interactive PDF format.

Click the title above to open the LCGC North America August 2015 regular issue, Vol 33 No 8, in an interactive PDF format.

Click the title above to open the LCGC North America August 2015 regular issue, Vol 33 No 8, in an interactive PDF format.

Water is the most common reagent in the laboratory but it is the most misunderstood and is often taken for granted. Learn how specific contaminants can affect your chromatography system and results and understand how to optimize water purification technologies to meet your experimental needs.

As part of a wider project funded by the Bill & Melinda Gates Foundation to develop sustainable next-generation toilets for lower-income countries (the “Reinvent the Toilet Challenge”), researchers have applied gas chromatography–mass spectrometry (GC–MS) to profile the malodour compounds in the headspace of latrines in Africa and India.

Profiling amino acids in scalp hair could aid the diagnosis of type 2 diabetes, according to a new study. Researchers performed gas chromatography–mass spectrometry (GC–MS) on hair samples taken from diagnosed patients and healthy patients to show that type 2 diabetes alters the amino acid composition of hair’s main building block, keratin, and that this biomarker could aid diagnosis in the clinic.

Click the title above to open The Column July 24, 2015 Europe & Asia issue, Volume 11, Number 13, in an interactive PDF format.

Click the title above to open The Column July 24, 2015 North American issue, Volume 11, Number 13, in an interactive PDF format.

The application of high resolution, accurate mass (HRAM) mass spectrometry coupled with multidimensional chromatographic separations, bioaffinity isolation techniques, and online sample preparation methods to detect, identify, and quantify emerging contaminants (including endocrine disruptors, pharmaceuticals, and surfactants) in wastewater and drinking water. The overarching goal of Lee’s research is to gain an increased understanding of how emerging contaminants are transported, transformed and induce deleterious effects within aquatic ecosystems.

A team of researchers in Spain has examined the use of commercial yeast products in the production of white and rosé sparkling wines. Using a range of analytical techniques, including gas chromatography–mass spectrometry (GC–MS) and high performance liquid chromatography (HPLC), the team examined four yeast autolysates to find out how they affect the chemical composition, foam, and sensory properties of sparkling wines aged on lees for nine months.

Dr. Graeme McAlister of Thermo Fisher Scientific will discuss the advances in Orbitrap Tribrid Mass Spectrometry technology with the launch of the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. Graeme will also touch on how these advances have impacted and will continue to impact proteomics with respect to quantitation, accuracy, throughput, etc.

Using ESI-MS to perform quantitative binding analyses and determine association constants depends on the ability of the ionization process to preserve the system equilibrium.

The application of high resolution, accurate mass (HRAM) mass spectrometry coupled with multidimensional chromatographic separations, bioaffinity isolation techniques, and online sample preparation methods to detect, identify, and quantify emerging contaminants (including endocrine disruptors, pharmaceuticals, and surfactants) in wastewater and drinking water. The overarching goal of Lee’s research is to gain an increased understanding of how emerging contaminants are transported, transformed and induce deleterious effects within aquatic ecosystems.