The use of ion-exchange sorbents for the preconcentration, separation and determination of metal ions is well established in the literature. Selection of an appropriate sorbent ensures both high efficiency in metal chelating while minimizing the mass of sorbent required for a particular analytical task. A high efficiency sorbent means that a smaller bed mass may be used thereby reducing the quantity of solvent required for elution yielding greater analytical sensitivity.
New research into flow modulation methods in valve-based two-dimensional gas chromatography (GC×GC) has produced an effective alternative to traditional pulse modulation.1 Described as “pattern modulation”, this new method increases effluent to the secondary column with flow rates compatible with most chromatographs and spectrometers.
Summary of the Eastern Analytical Symposium 2015.
A detection method for early-stage ovarian cancer has been developed using ultrahigh‑pressure liquid chromatography–high-resolution mass spectrometry (UHPLC–HRMS) in combination with tandem MS–MS.
Incognito talks about reproducibility in research.
The inherent sensitivity and selectivity of time-of-flight mass spectrometry (TOF-MS) can be augmented by soft electron ionization (EI) to provide ultratrace-level quantitation of organotins in complex environmental extracts. These organotin species are a focus of current concern as environmental contaminants, but analysis using conventional 70 eV ionization energies is made difficult by their propensity to undergo extensive fragmentation. The use of soft EI helps to solve this problem by producing simplified spectra with enhanced diagnostic ions.
Column overload is a very commonly encountered issue in gas chromatography (GC) for beginners. Changes in peak symmetry, generally observed as peak fronting, can be subtle in the sharp peaks generated by GC, but the result can be significant shifts in retention times, loss of resolution, and error in peak integration. LCGC Blogger Kevin Schug explains more.
A review of the 10th Balaton Symposium on High-Performance Separation Methods, which was held 2–4 September 2015 at the Hotel Azúr, Siófok, Hungary.
Click the title above to open The Column January 19, 2016 Europe & Asia issue, Volume 12, Number 1, in an interactive PDF format.
Click the title above to open The Column January 19, 2016 North American issue, Volume 12, Number 1, in an interactive PDF format.
After 10 years at U.T. Arlington, I have decided it is time to take one of the best opportunities afforded to researchers in an academic faculty position-to travel abroad and assimilate new techniques into my repertoire to enhance future research activities.
The EPA has updated methods 8270 (8270E) and 625 (625.1) to both now permit the use of solid phase extraction (SPE) to analyze for semi-volatile organic compounds (SVOCs) in aqueous samples and TCLP leachates. As a result of new advancements in instrumental sensitivity, smaller sample sizes can now be utilized to obtain required method detection limits, reducing solvent and standard consumptions and overall sample preparation time. This application note describes a reliable, efficient, and cost-effective SPE method utilizing two stacked cartridges for the extraction of 100 mL water samples or less.
Strongly retained sample compounds can cause various changes in the appearance of a chromatogram.
Cloud-point extraction (CPE) manipulates temperature and surfactant concentration to move aqueous solutes into a micelle phase for separation. Although CPE has been around for some time, it is still considered an emerging technique. Much of the development, and most applications, of CPE have dealt with extraction and preconcentration of inorganic solutes. More recently, attention has turned to the use of CPE in the isolation of organic solutes. This month, we review how CPE works and focus on applications for extracting organics.
These GC–MS instrument setup requirements are critical to success.
Click the title above to open the LCGC Europe January 2016 regular issue, Vol 29, No 1, in an interactive PDF format.
Click the title above to open the LCGC North America January 2016 regular issue, Vol 34 No 1, in an interactive PDF format.
There has been much written about the use of nitrogen as a carrier gas for capillary GC. Formerly, to say it wasn’t any good. Latterly to say that it’s pretty good and a better alternative to Helium than hydrogen from a practicality standpoint.
Anti-histamines and compounds used to medicate anxiety and seizures were among those identified in grocery market fish fillets using a novel gas chromatography–mass spectrometry (GC–MS) technique.
It is much more efficient to screen column chemistries to achieve optimum separations for a set of target analytes, than it is to play with different mobile-phase conditions on a single column. Kevin Schug explains more.
Click the title above to open The Column December 07, 2015 Europe & Asia issue, Volume 11, Number 22, in an interactive PDF format.
Click the title above to open The Column December 07, 2015 North American issue, Volume 11, Number 22, in an interactive PDF format.
Click the title above to open the LCGC North America December 2015 Corporate Capabilities Supplement, Vol 33 No s12, in an interactive PDF format.
In the first two parts of this series we have looked at where and how a CDS fitted into a regulated laboratory and the overall requirements for the architecture of a future system. In this part we focus on new electronic ways of working for chromatographic analysis.
A farewell letter from long-time LCGC columnist Ron Majors.
A short guide to the do’s, don’ts and gotcha’s of eluent preparation for everyday HPLC
In his final “Column Watch” article, Ron Majors looks into his crystal ball and discusses future needs in the area of HPLC/UHPLC column technology and related instrumentation. He looks at where current technology may be heading and makes a prediction that monolith-based columns may still have a rightful place in the HPLC/UHPLC laboratory .This article concludes his duration as a monthly columnist for LCGC.
Professor David S. Hage was awarded the Outstanding Achievements in Separation Science Award at this year’s Eastern Analytical Symposium and Exposition (EAS). The award honours analytical chemists who have distinguished career achievements and advanced their fields of study with superior work by developing theory, technique or instrumentation.
Professor Chris Enke won the Outstanding Achievements in the Fields of Analytical Chemistry Award at The Eastern Analytical Symposium and Exposition (EAS) this year. The award honours analytical chemists who have distinguished career achievements and advanced their fields of study with superior work by developing theory, technique or instrumentation.