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MilliporeSigma is now accepting entries for the Alfred R. Bader Award for Student Innovation.

Peak Scientific has expanded its operations in Latin American (LATAM), moving to a new, larger premise with the aim of developing its support capabilities in the growing LATAM market.

Molecular mass is one of the central parameters required for product registration. Compared to low molar mass substances, the molar mass determination of macromolecular products is more difficult because the product is a mixture of chains with different lengths and, therefore, molar masses. Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard technique to separate macromolecules by size and to measure the complete molar mass distribution as well as the molar mass averages. This technique therefore provides crucial information for product registration, including REACH.

A preview of HPLC 2017, which will be held from 18 to 22 June 2017 at the Prague Congress Centre, Prague, Czech Republic.

Analysis of residual antimicrobials in animal products is crucially important to ensure food safety. This article presents a simple, fast, and highly sensitive high performance liquid chromatography (HPLC) assay of regulated antimicrobials, as well as sample preparation and purification methods. Twenty-four different analytes of interest were investigated in beef, pork, and chicken meat samples.

Successful therapeutic intervention often requires chiral medicines because of the intrinsic chirality of protein drug targets, which consist of L-amino acids. Potency, efficacy, and safety can be highly dependent on the precise stereochemical geometry of the molecules. Determining the biological profile of individual enantiomers in the early stages of drug discovery is important for successful optimization towards clinical candidates. Here we demonstrate the benefits of supercritical fluid chromatography (SFC) with three chiral stationary phases exemplified by high frequency resolution of 41 out of 50 chiral derivatives of eight commonly used drug discovery scaffolds including 1,3-thiazoles, 1,3-benzothiazoles, pyranoquinolones, indoles, and leucolines.

A preview of the HPTLC 2017 symposium, which will take place this July.

Click the title above to open The Column June 06, 2017 Europe & Asia issue, Volume 13, Number 8, in an interactive PDF format.

Click the title above to open The Column June 06, 2017 North American issue, Volume 13, Number 8, in an interactive PDF format.

Click the title above to open the LCGC North America June 2017 Application Notebook, Vol 35 No s6, in an interactive PDF format.

Precise and accurate quantitative analysis based on chromatographic measurements has historically relied very heavily on careful peak integration. Seasoned analysts know that while automated algorithms exist in modern chromatography software, it is a best practice to manually check that the integration points-the points at the beginning and end of a peak, between which the peak will be integrated to obtain a peak area-are appropriately specified.

This information is supplementary to the article “Utility of the Summation Chromatographic Peak Integration Function to Avoid Manual Reintegrations in the Analysis of Targeted Analytes” that was published in the June 2017 LCGC North America issue (1). 

An excerpt from LCGC’s e-learning tutorial on high performance liquid chromatography (HPLC) methods at CHROMacademy.com

When you want to adjust a United States Pharmacopeia (USP) method for a different size column or to meet system suitability criteria that fail, how much of a change can you make without revalidating the method?

This yearly report on new products introduced at Pittcon 2017 (or in the preceding year) covers sample preparation instrumentation, supplies, and accessories.

In reversed-phase liquid chromatography (LC), C18 alkyl-based stationary phases have been the favourite of method developers. Phenyl stationary phases are an alternative that are thought to benefit from additional π-π mechanisms. Recently, there has been a growing interest in the use of phases based on the biphenyl moiety. This instalment of “Column Watch” looks at the retention mechanisms of biphenyl phases and contrasts them with those of more-common alkyl phases.

The 24th International Symposium on Electro- and Liquid Phase- Separation Techniques (ITP 2017) will be held in Sopot, Poland, at the Sheraton Hotel, 10–13 September 2017.

In biphenyl phases, the surface chemistry often makes it possible to separate compounds not well resolved by C18 or phenyl phases.

How much of a change can you make to a USP method without revalidating the method?

Improve your analysis of ionizable analytes with these hints and tips.

An introduction from the guest editor of this special supplement from LCGC Europe and LCGC North America revealing recent developments in high performance liquid chromatography (HPLC) and ultrahigh-pressure liquid chromatography (UHPLC).

In the 21st century, numerous advances have been made in liquid chromatography (LC) column technology. The best known are columns packed with sub-2-µm porous particles or sub-3-µm superficially particles, and monolithic columns. Another very novel and original development is micro-pillar array columns (µPAC). µPACs are produced by a lithographic etching process to create a perfectly ordered separation bed on a silicon chip. Although the performance in terms of efficiency has been illustrated, the applicability for analysis of real complex samples has yet to be fully demonstrated. This article illustrates that state‑of‑the‑art µPAC columns coated with octadecyl are applicable for a challenging application such as lipidomics. The performance is illustrated with the analysis of human blood plasma lipids.