A pilot study investigating whether nicotinamide adenine dinucleotide kinase (NADK) expression is selectively diminished in alcohol-associated liver cirrhosis (AC), as well as evaluating its potential as a biomarker for this condition, measured AC and non-AC (NAC). Nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) levels in human liver samples were measured using liquid chromatography-mass spectrometry (LC-MS).
A joint study between the University of Oklahoma Health Sciences Center (Oklahoma City, Oklahoma) and the UC Davis West Coast Metabolomics Center (Davis, California) identified differentially regulated lipids in type 2 diabetes (T2D) and obesity through the application of reversed-phase liquid chromatography-accurate mass tandem mass spectrometry (RP-LC-accurate MS/MS).
LCGC EAB member Paul Ferguson has been named a professor by special appointment at the Faculty of Science at the University of Amsterdam.
Polyamides can be difficult to characterize, despite their use in various aspects of everyday life. Vrije Universiteit Amsterdam researchers hoped to address this using a reversed-phase liquid chromatography (RPLC)-based approach.
Saba Aslani from the University of Texas at Arlington spoke to LCGC International about a collaborative project with Northwestern University, the University of Hong Kong, and BioTools, Inc., investigating mirror-image cyclodextrins using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) and vibrational circular dichroism (VCD).
In the final section of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he imparts the most important lessons he would like future generations of scientists to learn.
In the penultimate section of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he reflects on the people who guided him throughout his scientific career.
In the third part of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he discusses his time creating new liquid extractions and his feelings on seeing his work used around the world.
In the second part of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he discusses the most notable aspects of his previous research efforts.
A novel method called quantitative marinating (QM) was developed to reduce industrial waste during the processing of crayfish meat, with the taste, flavor, and aroma of crayfish meat processed by various techniques investigated. Headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) was used to determine volatile compounds of meat examined.
In the first part of our interview with Vilmos Kertesz of Oak Ridge National Laboratory, he reflects on his winning the 2025 Al Yergey MS Scientist Award and previews what his awards lecture will discuss.
Researchers developing a plant microbial consortium that can repair in-situ high concentration TNT (1434 mg/kg) contaminated soil, as well as overcome the limitations of previous studies that only focused on simulated pollution, used untargeted metabolone gas chromatography-mass spectrometry (GC-MS) to measure their success.
Researchers developing a plant microbial consortium that can repair in-situ high concentration TNT (1434 mg/kg) contaminated soil, as well as overcome the limitations of previous studies that only focused on simulated pollution, used untargeted metabolone gas chromatography-mass spectrometry (GC-MS) to measure their success.
A non-invasive wearable sampler combined with UHPLC–IMS-HRMS has been developed to identify biomarkers for TB using human skin
When analyzing samples using liquid chromatography–high-resolution mass spectrometry, there are various ways the processes can be improved. Researchers created new methods for prioritizing these strategies.
In the final part of our interview with Michael Shortreed, he shares the most important lessons he would like the next generation of mass spectrometrists to learn.
In the second part of our interview with Michael Shortreed, he reflects on how his work is used in laboratories worldwide and discusses those who mentored him throughout life.
LCGC International's April series for National Cannabis Awareness Month concludes with a discussion with Walter B. Wilson from the National Institute of Standard and Technology’s (NIST’s) Chemical Sciences Division regarding recent research his team conducted investigating chromatographic interferences that can potentially inflate the levels of Δ9-THC in Cannabis sativa plant samples, and possible solutions to avoid this problem.
In the first part of our interview with Michael Shortreed, we discuss his winning the Al Yergey MS Scientist Award and learn about his research on computational methods.
Here is some of the most popular content posted on LCGC International this week.
Come and meet the International Women in Chromatography at HPLC 2025 in Bruges, Belgium.
The United Kingdom banned menthol as a characteristic flavor in cigarettes in May 2020. Researchers tested cigarettes sold in 2021–2022 for menthol and other characterizing flavors through sensory and chemical testing, using gas chromatography–mass spectrometry (GC–MS) in their research.
Two-dimensional liquid chromatography (2D-LC) coupled to mass spectrometry (MS) has been used to separate proteins in the venom of the Indian cobra snake.
Researchers leveraged the advantages of thermodesorption, followed by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC/TOF-MS), to compare and assess a variety of sampling phases for body odor.
As part of the collaboration, BASF will contribute its R&D expertise in catalytic materials and technologies, while Mingyang will focus on applying its research capabilities to Power-to-X equipment.
A recent study conducted at the University of Georgia, (Athens, Georgia) presented a validated method for quantifying 18 terpenes in Cannabis sativa essential oil, extracted via hydrodistillation. The method, utilizing gas chromatography–mass spectrometry (GC–MS) with selected ion monitoring (SIM), includes using internal standards (n-tridecane and octadecane) for accurate analysis, with key validation parameters—such as specificity, accuracy, precision, and detection limits—thoroughly assessed. LCGC International spoke to Noelle Joy of the University of Georgia, corresponding author of this paper discussing the method, about its creation and benefits it offers the analytical community.
Here is some of the most popular content posted on LCGC International this week.
Green analytical chemistry is no longer a niche concept but a necessity in today’s environmentally conscious world.
We spoke with Josh Hoerner, general manager of Purisys, which specializes in a small volume custom synthesis and specialized controlled substance manufacturing, to gain his perspective on FDA’s recommendations for acceptable intake limits for N-nitrosamine impurities.
A new collaboration facility, opened by Thermo Fisher Scientific, will work to make cell therapy developers’ research more accessible and optimized.
