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ISC 2024 in Liverpool, U.K. included an illuminating session on contemporary omics applications.

This paper describes the content of a well-written analytical procedure for regulated high-performance liquid chromatography (HPLC) testing. A stability-indicating HPLC assay for a drug product illustrates the required components for regulatory compliance, including additional parameters to expedite a laboratory analyst’s execution.

A recent study aimed to characterize the fine-flavor cocoa in parent-hybrid combinations using widely targeted gas chromatography-mass spectrometry (GC–MS) and bean phenotype analysis.

A recent joint study between the Department of Forensic Science of the College of Criminal Justice at Sam Houston State University (Huntsville, Texas) and the Department of Criminal Justice of the School of Social Sciences at Ming Chuan University, (Taipei, Taiwan) developed artificial intelligence (AI) by transfer learning in a convolutional neural network (CNN), GoogLeNet, with the image classification AI fine-tuned to create intelligent classification systems to discriminate samples containing gasoline residues from burned substrates.

The article discusses the application of a hybrid organic/inorganic surface technology that forms a barrier between the sample and the metal surfaces of both the HPLC system and chromatographic column. Formed by a vapor deposition of an ethylene-bridged siloxane polymer on metal substrates), this technology effectively addresses common chromatographic challenges such as analyte loss, carryover, and peak tailing due to metal-analyte interactions. It improves peak symmetry and areas, as well as reproducibility, thereby not only benefiting challenging analytes but also increasing confidence in analytical results. We demonstrate the benefits of this technology through the analysis of B-group vitamins, steviol glycosides, and dextran oligosaccharides typically found in food, beverages, and dietary supplements, showcasing its critical role in improving chromatographic performance.

A joint study by the Department of Food and Nutritional Sciences at the University of Reading and Synergy Flavours aimed to identify volatiles that contribute to the aroma of cooked cheese, including the role of fat content in development during cooking.

Although automated peak detection functionalities are available in commercially accessible software, utilizing visual inspection and manual adjustments to achieve optimal true positive rates is often necessary. A recent study conducted by the Department of Chemical Engineering at the Indian Institute of Technology (Delhi, India) used liquid chromatography-mass spectrometry (LC–MS) to distinguish hetero-variants (glycoforms) resulting in a monoclonal antibody (mAb) able to be characterized, revealing discernible peaks at the intact level. LCGC International spoke to Anurag Rathore, corresponding author for the article, about his department’s findings.

Researchers are pushing the boundaries of traditional column design and improving overall chromatographic performance.

Researchers from the Department of Bioscience and Technology for Food, Agriculture and Environment at the University of Teramo (Italy) used gas chromatography-mass spectrometry (GC-MS) investigated the contribution of Kluyveromyces marxianus to the gross composition and aroma profile of cow cheeses.

A pilot study conducted by the University of Split School of Medicine (Split, Croatia) used gas chromatography-mass spectrometry (GC–MS) to measure the urine levels of nicotine and its metabolites in research participants exposed to second-hand smoke in nightclubs.

Regarded as one of the pioneers of the green chemistry movement, John Warner took the stage at the ISC in Liverpool to speak about the pivotal role separation scientists must play in advancing green chemistry.

A recent study ascertained metabolic biomarkers and investigated the metabolic alterations associated with aqueous humor (AH) in wet age-related macular degeneration (AMD). Analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify and quantify metabolites.

Bram Huygens’ research focuses on developing a deeper understanding of the factors influencing separation efficiency by using advanced mathematical techniques to analyze mass transfer phenomena.

Amarande Murisier has earned recognition in the field of biopharmaceutical separation sciences with method development of SEC and IEC hyphenated with MS.

Alexandre Goyon specializes in developing advanced analytical methods to support new drug modalities.

Caitlin Cain has developed one-dimensional and comprehensive two-dimensional gas chromatographic methods using novel data analysis approaches.

A morning session at the International Symposium on Chromatography in Liverpool presented analytical challenges and potential solutions for PFAS analysis, oil pollution, and microplastics.

A new, fast, and accurate method to measure the levels of ivermectin in blood and plasma samples was developed using a new technique to prepare the samples and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze them.

The 34th International Symposium on Chromatography kicked off on October 6 in Liverpool, featuring two plenary sessions and an opening ceremony.

A recent study examined three drug overdose deaths resulting from an Italian prison riot during the initial wave of the SARS-CoV-2 pandemic. To ascertain the nature of these deaths, a comprehensive toxicological analysis was conducted, employing gas chromatography-mass spectrometry to reveal high concentrations of various substances in the biological fluids of the deceased inmates.

The influence of chitosan's physicochemical characteristics on the functionality of lactic acid bacteria and the production of lactic acid remains very obscure and contradictory to date, thus inspiring a research team to study the effect of chitosan on growth and productivity of that bacteria in its presence.

Changes in volatile compounds (VCs) during air frying of tilapia were researched in a recent study by quantitative gas chromatography–ion mobility spectrometry, followed by the identification of key VCs based on their odor activity value (OAV).

A recent study focused on identifying molecular markers capable of discriminating between different origins and, at the same time, predicting their sensory attributes adopting a sensomics approach. An untargeted method was adopted, based on the coupling of ultra-high performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS), followed by the application of chemometric tools for the selection of 71 discriminating molecular markers for six origins.

A recent study determined the insecticidal activity of essential oils (EOs) from leaves of P. aduncum cultivated in southeastern Brazil, collected during the dry and rainy seasons, against fleas. Through this research, researchers hope to promote the utilization of these natural resources, particularly those now in cultivation and available for industry, in ways that align with traditional practices.

Julien Crepier of TotalEnergies was one of the researchers that conducted this study, and he recently sat down with LCGC International to talk about his team’s findings.

A recent study focused on improving the flavor of beef from Xinjiang brown cattle utilized two-dimensional gas chromatography–time-of-flight mass spectrometry (GC×GC-TOF MS to analyze volatile flavor compounds across different beef cuts.

ACD/Labs, a leading informatics company specializing in software for digitalizing R&D, has announced the release of version 2024 of its Spectrus Platform applications.

A recent study investigated the significance of quantifying amino acids in minute sweat volumes using high performance liquid chromatography (HPLC) with fluorescence (FL) detection, offering a non-invasive and efficient way to screen for diseases by detecting amino acids in sweat, even with minimal sweat volumes.