Mass Spectrometry

At Pittcon 2023, LCGC spoke with Jim Grinias of Rowan University. This segment is the full-length version of the interview that was conducted at the conference.

What parameters can influence an siRNA separation?

How to enhance the sensitivity, specificity, and speed of metabolite measurement using TIMS, which in turn helps to accelerate the pace of metabolomics research.

A team of researchers from the University of Barcelona has developed a new method for the selective extraction of monosaccharide anhydrides from sediment samples, which is crucial for their analysis.

How can low-resolution mass spectrometry (LRMS) and high-resolution (HR) MS work together to provide unambiguous results in clinical and forensic toxicology?

A new study reports the development a highly sensitive LC–MS/MS method to measure salivary melatonin levels. The method has a lower limit of the measuring interval of 0.8 pg/mL, making it the most sensitive method for quantifying melatonin in saliva.

A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.

A new article discusses the benefits and drawbacks of RPLC and RPLC×RPLC chromatography techniques. It provides recommendations for selecting the best approach for analyzing small pharmaceuticals and peptides.

A solid-phase microextraction (SPME) Arrow combined with comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC–MS) identified about 40 more volatile compounds in a variety of whiskeys compared to conventional SPME.

Samples of the prefrontal cortex, striatum, and hippocampus of rats were analyzed by LC–MS to assess brain tissue response to combined consumption of ethanol and cocaine.

A recent study analyzed the composition and metabolism of steroidal alkaloids in Solanum nigrum fruits of different maturities and identified steroidal glycoalkaloids and steroidal alkaloids, providing a foundation for further research on biosynthesis and discovery of new steroidal alkaloid anticancer drugs.

A new published study introduces a simple and fast way to differentiate between animal species based on their hair. The in-sample digestion method coupled with mass spectrometry analysis was successfully tested on multiple species.

A new study has identified potential quality-markers for Eucommiae Folium (Duzhongye), a traditional Chinese medicine, using UHPLC–MS/MS analysis, and has recommended isoquercitrin as a new quality-marker candidate.

The reliability of column chromatography for GC–MS analysis of hopanes was tested in oil samples of three different types, using neutral alumina as a solid-phase adsorbent and a Pasteur pipette as a separation device.

A new approach for identifying isomeric and isobaric metabolites has been developed using liquid chromatography (LC) with high-resolution ion mobility spectrometry (IMS) and cryogenic infrared (IR) spectroscopy, allowing for faster, more accurate, and cost-effective metabolomics workflows.

Webinar Date/Time: Wed, Jun 28, 2023 1:00 PM EDT

Researchers combine a single-probe single cell mass spectrometry technique with a bioinformatics software package to quantify cell subpopulations and prioritize metabolite biomarkers, providing a label-free approach to studying cell heterogeneity and improving understanding of cell metabolism in human diseases and response to therapy.

Researchers have developed a PAMAM-functionalized paper substrate that boosts the sensitivity of protein analysis by paper spray mass spectrometry (PS-MS), potentially revolutionizing clinical diagnosis of diseases.

A micro-pillar array format for mapping the proteome of human stem cell-derived liver organoids using timsTOF–MS is presented.

A new study analyzed the trophic niches and niche overlap between native and introduced cyprinid fishes in Karacaören I reservoir using IRMS.

A new RPLC–MS method can map the substitution degree and composition of β-glucose monomers of cellulose ethers (CEs), providing detailed compositional distributions and constitutional isomer distributions, thereby identifying compositional variation between bio-stable and non-bio-stable CEs and unexpected methylations in EHEC samples.

High performance liquid chromatography–mass spectrometry and gas chromatography–mass spectrometry, along with numerous extraction methods, are helping to find organosulfur compounds in food more easily, providing researchers better information about the health benefits of these substances.

A recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.

Limitations often arise when using GC with quadrupole-based mass spectrometers for detecting volatile and semivolatile contaminants. Enter HRAMS-MS.

A new fragmentation approach—tunable electron-activated dissociation (EAD) tandem mass spectrometry (MS/MS)—offers a solution to better improve the detection and characterization of impurities in lipid nanoparticles and impurities in other biopharmaceutical modalities.