Researchers from Sapienza Università di Roma and ETH Zürich investigated the performance of micro- and nano-liquid chromatography systems by examining how capillary LC behaves under varying operational conditions.
Researchers at LUT University highlight challenges in calculating adsorption values during aqueous chromatography and explore new methods to close this knowledge gap.
A new study done by scientists in Switzerland and Sweden investigated the use of automated systems to develop multispecific antibodies.
Circular dichroism and fluorescence were used to create a platform for monitoring changes in monoclonal antibodies.
To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) was used to quantify antitumor prodrugs and their metabolites.
A new cancer detection test to analyze volatile organic compounds through urine analysis, was granted the Breakthrough Device Designation status by the U.S. FDA. The system, which is built on gas chromatography–mass spectrometry (GC–MS) and proprietary AI, generates real-time cancer risk scores.
Scientists from the Technical University of Munich and Lund University explored the use of new models for liquid-liquid chromatography based off pre-existing procedures for liquid-liquid extraction.
A gas chromatography–mass spectrometry-based approach was created and optimized to analyze reaction products of partial isobutane oxidation.
New upgrades to the Waters Corporation Alliance iS HPLC System Software systems were recently discussed at HPLC 2025.
Cryogenic systems were recently tested for their ability to improve gas chromatography’s ability to modulate multi-component mixtures.
Molecular simulations, while useful in chromatographic biomolecule analysis, can be complex to set up and run. Researchers aimed to simplify these processes using two workflow management systems.
Hydrophobic interaction chromatography (HIC) is useful, albeit costly, for purifying proteins. Researchers aimed to reformulate HIC isotherms using salt-dependent water activity to optimize the process.
This article reports on new products introduced at Pittcon this year and in the preceding year related to sample preparation instruments, supplies, and accessories.
This review highlights the high performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products that were introduced from 2024 to 2025, summarizing the technical specifications of each product and highlighting significant user benefits.
The latest edition of “GC Connections” presents an annual review of new developments in the field of gas chromatography introduced in 2024–2025.
To meet the increasing worldwide demand for monoclonal antibodies, it is crucial to develop purification methods that are both efficient and easily scalable. Membrane chromatography offers a promising solution for streamlining antibody purification, thanks to its ability to handle high processing volumes rapidly. Convective membrane chromatography has become popular for purifying monoclonal antibodies. Researchers created a new model for modeling mass transfer during purification.
High-temperature gas chromatography (HTGC) is typically limited by a lack usable stationary phases. University of Rouen-Normandy researchers created their own stationary phases and tested them under HTGC conditions.
A new tutorial article has been created focusing on the best practices in batch sorption when removing contaminants using biochar-based techniques.
A new paper presents the design of a needle-plate dielectric barrier discharge DBD ion source based on 3D printing for high field asymmetric-waveform ion-mobility spectrometry (FAIMS).
AI-powered tools are enhancing precision, efficiency, and decision-making in biopharmaceutical development. Recently, Jared Auclair and Anurag Rathore explored AI's evolving role in biopharmaceuticals in detail.
In this month's edition of LC Troubleshooting, Dwight Stoll and his fellow researchers discuss both the benefits (improved peak shape/loading) and challenges (excessive interaction) associated with charge-doped reversed-phase (RP) columns for both analytical and preparative separations.
3D printing technology has potential in chromatography, but a major challenge is developing materials with both high porosity and robust mechanical properties. Recently, scientists compared the separation performances of eight different 3D printable stationary phases.
Ion mobility spectrometers can detect trace compounds quickly, though they can face various issues with detecting certain peaks. University of Hannover scientists created a new system for resolving hyper-fast gas chromatography (GC) peaks.
Many multi-column gas chromatography systems use two-position multi-port switching valves, which can suffer from delays in valve switching. Shimadzu researchers aimed to create a new sampling and switching module for these systems.
Polyamides can be difficult to characterize, despite their use in various aspects of everyday life. Vrije Universiteit Amsterdam researchers hoped to address this using a reversed-phase liquid chromatography (RPLC)-based approach.
