Application Notes: General

This eBook explores the evolution of HPLC from a breakthrough analytical technique into a modern, software-assisted framework for Analytical Quality by Design (AQbD). Through expert perspectives and real-world use cases, readers will learn how design-space modeling, lifecycle management, and in-silico robustness testing can streamline method development, improve transferability, and support regulatory compliance.

The EDGE PFAS™ system simplifies and accelerates PFAS extraction with a fully automated workflow that meets EPA Method 1633 requirements. Delivering results in under 15 minutes per sample, it enables faster throughput while maintaining clean, reliable performance.

PFAS “forever chemicals” continue to accumulate in soil and tissue, driving the need for faster, more reliable environmental testing. This study demonstrates how automated extraction following EPA Method 1633A enables efficient analysis of 40 PFAS compounds from complex sample types. Using the EDGE PFAS system, extractions were completed in under 15 minutes per sample with strong recoveries and no carryover. The approach supports high-throughput workflows while maintaining accuracy and consistency in PFAS monitoring.

Streamline PFAS analysis with automated SPE using dual-phase WAX/Carbon S cartridges, delivering reliable recoveries and improved lab efficiency in compliance with US EPA Method 1633.

In this “Pittcon 2026 Highlights” e-book, explore the latest ongoing advancements in analytical chemistry and spectroscopy presented at the Pittcon 2026 conference. This resource covers hot topics such as PFAS forensics, microplastics analysis, green chemistry, and generative artificial intelligence (AI). Gain a quick look at the technologies shaping analytical chemistry and spectroscopy in 2026.

PFAS are long-lasting chemical compounds used in many industrial and consumer applications, now widely detected in the environment and linked to potential health concerns. This eBook gathers studies on PFAS presence in air, soil, and water, exploring exposure pathways, analytical approaches, and ongoing efforts to better understand and address their environmental persistence.

PFAS are highly persistent fluorinated compounds widely used for their resistance to heat, water, and chemicals. They are now detected globally in air, water, soil, and rain. This infographic highlights environmental concerns, evolving regulations, and practical guidance for PFAS sampling and preparation to support accurate monitoring and improved analytical outcomes.

PFAS are persistent “forever chemicals” used across multiple industries and found in the environment. This application note explores LC-MS/MS and CIC methods showing how Arium® Comfort I UV reduces PFAS contamination in water to ultra-trace levels, enabling reliable detection, improved sustainability, and cost-effective in-house ultrapure water production.

This eBook serves as a practical guide to selecting the right laboratory water purification system. It explains common water impurities, key lab water standards such as ultrapure and reverse osmosis, and core purification methods. It also outlines critical factors to consider when choosing a system to ensure reliable experimental results.

Adapting high-performance liquid chromatography (HPLC) methods to the capillary scale opens new possibilities for pharmaceutical analysis and sustainability. This paper, featuring a collaboration with the University of Pavia and Axcend, examines real-world method conversions that preserve performance while minimizing waste. Case studies include detection of a polar impurity in pediatric ibuprofen mini-tablets using a micro-HPLC-UV method, and a USP <621> guided adaptation for hydrochlorothiazide demonstrating over 99% solvent reduction. Practical guidelines, expected trade-offs, and data from both academic and regulated environments will offer a roadmap to adapting validated pharmaceutical monographs to the capillary scale without the need for revalidation.

Educational ebook on QA/QC workflows and applications

Single-run analysis of 117 VOCs including PAMS, air toxics and OVOCs, delivering compliant performance at 100% humidity without cryogen or extended cycle times.

Reliable TO-15 analysis of air toxics from canisters at up to 100% humidity, achieving low ppt detection limits with robust water management and consistent performance.

Enthalpy Analytical improves throughput and reliability for humid environmental air samples, overcoming moisture challenges while maintaining productivity and data quality.

Automated TD–GC–MS analysis of air toxics using sorbent tubes, delivering compliant TO-17 performance, low detection limits, and flexible sample re-analysis.

Continuous cryogen-free monitoring of ozone precursors and polar VOCs, enabling low detection limits and reliable analysis of humid air without compound losses.

PFAS in air: Validating ASTM D8591 for measuring airborne fluorotelomer alcohols, achieving low pg detection limits with robust data quality.

Learn how proper water purification eliminates PFAS background, enabling ultra sensitive LC MS/MS analysis with confidence using EPA 1633 ready ultrapure water outputs.

Meet labeling demands with confidence. Hamilton’s RCX-30 column enables accurate quantification of five key sugars for compliant, high-throughput food and beverage QC.

Hamilton's PRP-Z2 solves analytical challenges of EPA-regulated diquat and paraquat separation through enhanced design, enabling fast, robust analysis with improved throughput and reduced solvent use.

Fast, accurate sugar analysis for food quality and labeling. Hamilton's HC-75 Ca++ column separates 8 sweeteners in under 15 minutes using only DI water.

PRP-Z2 columns enable high-resolution oligonucleotide separation with robust performance, reduced salt use, and scalability for research and regulated workflows.

Optimize fermentation faster and cheaper. Discover how Hamilton’s HC75 column speeds analysis, sharpens resolution, and boosts quality control in brewing and biofuels.

Control wine flavor and consistency. Hamilton’s HC-75 H+ resin simplifies organic acid and carbohydrate analysis for reliable fermentation and premium wines.