Application Notes: General

Discover how the PET Recycling Team is setting new standards in recycled material performance using the GC 2400 systems to transform quality control process and accelerate your sustainability goals

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

The study was done to validate method performance for the expanded list of PFAS compounds required by the State of California Water Resources Board for wastewater.

Dynamic Focusing enables cryogen-free trapping of VOCs and VVOCs from ambient air, delivering method-compliant sensitivity and precision for TO-17 and ISO 16000-6.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using GCMS 2400, ensuring compliance, sensitivity, and resolution.

Discover a robust GC headspace method for accurate, low-carryover detection of residual NMP in Li-ion batteries using the GC 2400 and HS 2400M systems.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

A robust HS-GC-FID workflow on the GC 2400™ and HS 2400™ enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Quantify 1,4-dioxane in water and cosmetics with trace-level accuracy using PerkinElmer's GCMS Headspace Sampler.

Separations of Oligonucleotides using HALO 1000 Å OLIGO C18 show improved peak capacity, narrower peaks, and lower backpressure vs. 300 Å FPP columns.

HALO 1000 Å OLIGO C18 enables high-resolution impurity analysis of 90-mer ssDNA, outperforming competitors in peak capacity and separation efficiency.

Larger pore columns improve efficiency and reduce band dispersion in oligonucleotide separations-especially at high flow rates and longer chain lengths.

Longer columns paired with scaled gradients enhance oligonucleotide resolution especially for complex mixtures up to 100 nucleotides in length.

Discover how HALO® OLIGO C18 columns improve DNA/RNA separation with optimized ion pairing, pH control, and particle morphology for faster, sharper results.

BioCore HIC column family separate protein-based biotherapeutics and characterizing their critical quality attributes, including DAR and drug distribution in ADCs

Actively recording calibration gas data... creates unique advantages over traditional cylinder gas calibration.

Growing concern over artificial sweeteners has underscored the need to better understand their impact on human metabolism and health. Researchers at the University of Applied Sciences and Arts Northwestern Switzerland (FHNW) have developed a robust workflow to detect sugar alcohols and related metabolites in biological samples. This article highlights their latest findings and demonstrates how GC– MS/MS, in combination with automated sample preparation and dried blood spot (DBS) analysis, is evolving into a powerful approach for studying sweetener metabolism in a holistic, system-wide context.

Throughout drug development, it is important to characterize and quantify pharmaceutical compounds and any associated metabolites to ensure proper drug safety and efficacy. LC-MS/MS techniques are predominantly used for such analyses because they provide a comprehensive outlook and can offer a sensitive and selective approach for the quantification of compounds. However, limited deep fragment coverage and sensitivity challenge the confident identification and quantification of metabolites and drug products. Here, alternative fragmentation paired with a highly sensitive QTOF system was employed for comprehensive data collection to properly identify metabolites and quantify complex peptide therapeutics.

• The identification of drug metabolites is a critical step in drug development due to their impact on drug efficacy and safety. LC-MS platforms provide good selectivity and sensitivity making it the preferred technique for metabolite identification. Here, metabolite identification was performed using unique fragments from EAD and CID spectra. Fragment information from EAD and CID spectra were processed in a single result file to achieve confident structure assignment of and localization of metabolites.

Learn about the end-to-end solution for metabolite identification from method development to analysis.

Discover how the targeted metabolomics screening workflow employing integrated SCIEX OS Software with the X500 QTOF System can benefit your lab.

This technical note describes the identification of pioglitazone phase 1 metabolites from a hepatocyte incubation using comprehensive spectral data from an orthogonal fragmentation technique. More informative MS/MS spectra provided by EAD aided in the software-based identification of phase 1 metabolites to support drug metabolism studies.

This technical note demonstrates the comprehensive characterization and confident identification of glucuronide metabolites from hepatocyte incubations of midazolam.

This Technical Note presents AEX as a refined and more robust alternative to commonly applied analytical workflows for encapsulation efficiency determination.

Improve analysis of betamethasone derivatives with CORTECS™ Premier C8 Columns featuring MaxPeak™ HPS Technology for sharper peaks and better analytical performance.

Improve validated HPLC methods by switching from fully porous to CORTECS™ Premier C18 5 µm Columns to boost throughput, cut solvent use, and enhance method greenness.

CDMS is reshaping the characterization of complex biotherapeutics by enabling precise analysis of large, heterogeneous biomolecular complexes and gene therapy vectors. This article explores how CDMS enhances resolution in quality assessments across biotherapeutic development and structural biology research—surpassing the capabilities of conventional analytical techniques.