Application Notes: General

Cells beyond their sell-by date exhibit a higher probability to propagate damaged cellular components like DNA, which leads to disease. It is therefore necessary for the body to remove these old malfunctioning cells, which can be done with garlic. All of the active components of garlic are easily isolated using the 5 µm PRP-C18 HPLC column.

Capsaicin, the compound responsible for the burning sensation in chili peppers, has been researched for its potential therapeutic benefits, including reducing cholesterol and blood sugar levels, and exhibiting anti-inflammatory and analgesic properties. Hamilton's PRP-C18 reversed-phase HPLC column was used to isolate major capsaicinoids, with formic acid as the aqueous mobile phase, achieving good correlation with literature values at 10190 Scoville Heat Units. The Hamilton PRP-C18 column demonstrated excellent peak shape and can be easily regenerated, making it an indispensable tool for synthetic chemists.

In this study of an essential oil, we have developed an HPLC method for the separation of 6 well-known markers for the determination of purity of Ylang-Ylang oil.

Due to the short half-life of the 18F radionuclide, radiotracers are preferably produced locally or transported over short distances, leading to local production. On-site quality control is critical before clinical use. See how the RCX-10 enables reliable analysis for radiotracers.

This study analyzed BPA and its derivatives leaching from BPA-free polycarbonate water bottles using HPLC with UV detection and found that these bottles still contain bisphenol derivatives that can leach into water or ethanol. Leaching increased with temperature and was more pronounced with ethanol than hot water. Repeated washing with either hot water or 40% ethanol effectively removed leachable bisphenols without damaging the bottles.

Learn how biomarkers, Organ on a Chip Models models and PBPK tools improve toxicity and DDI prediction, cut false positives, and support clearer, ICH M12-aligned decision-making.

Metrohm’s MiPCT-ME technique enables trace-level determination of anions in N-methylpyrrolidone, ensuring lithium-ion battery quality, stability, and safety.

The GERSTEL TVOC Wizard streamlines and accelerates VDA 278 material emissions data processing by combining automated workflows, advanced deconvolution, and integrated NIST-based compound identification. Complex chromatograms—often dominated by co-eluting peaks—are reliably resolved using MCR-AR Targeted algorithms, while retention indices and customizable process steps ensure standard-compliant, high-quality results. The software eliminates error-prone manual transfers, increases data consistency, and delivers clear, customizable VOC and FOG reports aligned with industry requirements.

This method showcases a precise, automated workflow for determining methylene chloride in indoor air using thermal desorption GC-MS and GERSTEL’s ISDP module. Automated gaseous internal standard addition ensures highly reproducible tube spiking, while optimized TD and GC-MS parameters provide sensitive and stable quantification—well below OSHA exposure limits. The approach enables accurate baseline monitoring in laboratories, offices, and industrial environments where regulatory compliance and worker protection are essential.

Discover how the PET Recycling Team is setting new standards in recycled material performance using the GC 2400 systems to transform quality control process and accelerate your sustainability goals

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

The study was done to validate method performance for the expanded list of PFAS compounds required by the State of California Water Resources Board for wastewater.

Dynamic Focusing enables cryogen-free trapping of VOCs and VVOCs from ambient air, delivering method-compliant sensitivity and precision for TO-17 and ISO 16000-6.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using GCMS 2400, ensuring compliance, sensitivity, and resolution.

Discover a robust GC headspace method for accurate, low-carryover detection of residual NMP in Li-ion batteries using the GC 2400 and HS 2400M systems.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

A robust HS-GC-FID workflow on the GC 2400™ and HS 2400™ enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Quantify 1,4-dioxane in water and cosmetics with trace-level accuracy using PerkinElmer's GCMS Headspace Sampler.

In this application note, we demonstrate the separation of the full suite of 40 PFAS compounds including a separation of at least 1 minute between TDCA and PFOS.

Separations of Oligonucleotides using HALO 1000 Å OLIGO C18 show improved peak capacity, narrower peaks, and lower backpressure vs. 300 Å FPP columns.

HALO 1000 Å OLIGO C18 enables high-resolution impurity analysis of 90-mer ssDNA, outperforming competitors in peak capacity and separation efficiency.

Larger pore columns improve efficiency and reduce band dispersion in oligonucleotide separations-especially at high flow rates and longer chain lengths.

Longer columns paired with scaled gradients enhance oligonucleotide resolution especially for complex mixtures up to 100 nucleotides in length.

Discover how HALO® OLIGO C18 columns improve DNA/RNA separation with optimized ion pairing, pH control, and particle morphology for faster, sharper results.

BioCore HIC column family separate protein-based biotherapeutics and characterizing their critical quality attributes, including DAR and drug distribution in ADCs

Actively recording calibration gas data... creates unique advantages over traditional cylinder gas calibration.

Growing concern over artificial sweeteners has underscored the need to better understand their impact on human metabolism and health. Researchers at the University of Applied Sciences and Arts Northwestern Switzerland (FHNW) have developed a robust workflow to detect sugar alcohols and related metabolites in biological samples. This article highlights their latest findings and demonstrates how GC– MS/MS, in combination with automated sample preparation and dried blood spot (DBS) analysis, is evolving into a powerful approach for studying sweetener metabolism in a holistic, system-wide context.

Throughout drug development, it is important to characterize and quantify pharmaceutical compounds and any associated metabolites to ensure proper drug safety and efficacy. LC-MS/MS techniques are predominantly used for such analyses because they provide a comprehensive outlook and can offer a sensitive and selective approach for the quantification of compounds. However, limited deep fragment coverage and sensitivity challenge the confident identification and quantification of metabolites and drug products. Here, alternative fragmentation paired with a highly sensitive QTOF system was employed for comprehensive data collection to properly identify metabolites and quantify complex peptide therapeutics.