Application Notes: General
Multi-Class DUID Drug Method for 127 Analytes in Blood and Urine by LC-MS/MS
March 13th 2024Advances in LC-MS/MS technology have allowed for a more comprehensive and rapid multi-class drug method to be developed. This highlighted method allows for the use of a protein precipitation and sample filtration with Thomson eXtreme|Filter Vials® followed by a rapid 8 min/sample run time, thus allowing for the reduction in multiple LC-MS/MS methods being run in the laboratory, freeing up valuable instrument time.
Simple Rapid Analysis of Ethylene Oxide in a Polysorbate 80 Excipient Using SIFT-MS
March 5th 2024Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a daily sample throughput that is 9- to 14-fold higher. In this application note, a simplified EtO method is presented that uses a much smaller quantity of PS80 for analysis than headspace GC-FID.
Simple Rapid Analysis of Formaldehyde Impurities in Gelucire
March 5th 2024This application note describes how SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization. Sample throughputs of up to 250+ samples/day are possible using the method detailed in this study.