Application Notes: General

This case study demonstrates how method modernization is less difficult than the common perception, and good practices can be put in place to streamline the process.  

NIST mAb was analyzed using six different batches of 1.8 µm 200 Å dSEC-2 media packed with 150 mm length and 4.6 mm inner diameter columns.

Method development using standard phosphate containing buffers with different percentages of Isopropanol for aggregate analysis of an antibody-drug conjugate, Kadcyla.

Learn more about enzyme assay, enzyme method, and choices. Are you seeking a better way to automate your enzyme analysis? This guide will help with your decision-making.

The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions.

Higher peak area for Biozen dSEC 2 column showing less adsorption occurring. Superior peak shape and recovery under USP mobile-phase conditions with Biozen dSEC 2 column.

Robustness of guard and attached analytical column evaluated for efficiency of trastuzumab biosimilar Kanjinti at suitable loading masses of bovine serum albumin.

Protein standards explored with known hydrodynamic radii, show how this can determine ideal size-exclusion conditions for optimal method performance using Biozen columns.

This application note presents a fast HPTLC screening method for the identification of the most relevant forensic drugs.

Size-exclusion method improvements by running at a lower flow rate for the aggregate analysis of NIST mAb using a Biozen dSEC-2 column

This technical note demonstrates the characterization of subunits for three monoclonal antibodies, post digestion with IdeS, using the Biozen dSEC-2 size-exclusion column.

This LPGC–MS pesticides analysis utilizes a low-pressure GC column kit, comprised of a narrow restrictor column, factory coupled to a wider Rtx-5ms analytical column.  

Benzodiazepines are depressants and used to relieve anxiety, insomnia, and more. This app note discusses a urine extraction to confirm the presence of benzodiazepines.

A simple and robust method for the analysis of Opioids in biological matrices using UCT's Clean Screen® DAU SPE column and Selectra® DA UHPLC column.

Analyzing crops for beneficial and harmful compounds is an indispensable tool for assessing the viability of various agricultural crops for consumption.

This application note demonstrates a quick temperature ramp technique to improve the focusing of VOCs without a need for trapping.

This application note discusses SEC and how to reduce undesired secondary interactions between proteins and the LC column hardware.

This application note reviews use a of new SEC column technology to streamline method development for reliable size-variant analysis of therapeutic proteins.

This application note discusses synergistic coupling of new SEC particle and hardware technologies to reduce non-desired secondary interactions in protein SEC analyses.

Light scattering methods inform on essential properties and attributes of vaccines including size, aggregation, stability, interactions, composition, and conformation.

This application note discusses the advantages of using Waters XBridge™ Premier Protein SEC column in the published USP monograph for SEC-based mAb analyses.

This application shows a highly sensitive and selective quantitative analysis for macrolides with poor UV absorbance using single-quad LC–MS.

This article describes an example of using single quad LC–MS to check the synthesis of organic EL materials and predict the molecular weights of impurities they contain.

Report shows how using LC–MS as part of an analysis makes it easy to obtain molecular weight information of APIs for easy peak identification.

This article describes analyses of saccharides in non-sugar beverages separated by hydrophilic interaction liquid chromatography and detected with LC–MS.

This application shows how a compact, easy-to-operate single-quad LC–MS system can perform food metabolomics, opening up this analysis to users with minimal experience.