Application Notes: General

Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column, ensuring symmetric peaks, high sensitivity, and no carryover effects.

The separation of three cell-penetrating peptides (CPPs) was performed using a YMC-Triart C18 UHPLC column, providing sharp peaks for a fast analysis in under 4 min.

Twenty-eight PFAS in human serum were analyzed using a YMC-Triart C18 column. An automated SPE system was coupled to an online SPE column-switching LC–MS/MS method.

Four hydrophilic dipeptides were separated with excellent resolution using a YMC-Triart SIL column. Even structurally similar dipeptides were separated in under 4 min.

The UHPLC analysis of four cyclic peptides is shown. Based on the hydrophobicity of the peptides, a YMC-Triart Bio C4 UHPLC column was chosen for this application.

The analysis of FMOC-derivatized glyphosate and AMPA in water samples was performed using a YMC-Triart C18 UHPLC column at an elevated pH of 9.5.

Methods migration from updating analytical equipment can be a time consuming task. This paper shows many examples of method compatibility and analytical equivalency.

LC–MS workflow for accurate quantification/detection of individual host cell proteins, from sample preparation to the reporting of values of process-related impurities.

USP-compliant assay analysis of hydrocortisone using a PerkinElmer LC 300 HPLC System

Efficient and compliant HPLC analysis of pregabalin

Determination of four complex carbohydrates utilizing a PerkinElmer LC 300 HPLC System, a hydrophilic interaction chromatography (HILIC) technique

HPLC method for saccharide content determination via method CRA SACCH.03 through the analysis of nine commercially available high fructose corn syrups

A review of considerations when optimizing high-throughput methods and achieving fast analyses on Avantor® ACE® HTP-MS columns with examples of key LC–MS separations.

Determination of 16 common cannabinoids utilizing a PerkinElmer LC 300 HPLC System

A robust and sensitive HPLC method with multi-wavelength UV–vis detector for the analysis of 2-phenoxyethanol and seven parabens in commercially available PCPs

USP-compliant method for determination of six isoflavone compounds in dietary supplement capsules with the PerkinElmer LC 300 UHPLC System with PDA detector

A rapid and simple LC method for the analysis of six common VOC metabolites in urine for monitoring occupational exposure to VOCs

This application notes introduces an SPE LC–MS/MS methodology using the Microlute™ CP SCX SPE 96-well microplate for the determination of 12 opioids from human urine.

LPGC–MS is a technique that uses the MS vacuum system, along with a specially designed column setup, to lower pressure inside the entire column, speeding up analysis.

This application note describes how human milk oligosaccharides (HMO) can be analyzed by HPTLC during different production steps (fermentation and finished products).

This application note outlines the fractionation of hydrocarbons into aliphatic and aromatic fractions using UCT’s new silver-phase EPH fractionation cartridges.

 In this application note we demonstrate the excellent performance of Sapiens-624MS columns for the analysis of e-liquids based on ISO 20714.

A robust and sensitive HPLC method with multi-wavelength UV–vis detector for the analysis of 2-phenoxyethanol and seven parabens in commercially available PCPs .

This application note demonstrates rapid peptide desalting prior to LC-MS analysis in Proteomics research using different micropipette SPE StageTips packed with CDS Analytical’s Empore SPE membranes.

Critical quality attributes of lentivirus vector products can be assessed by centrifugal field-flow fractionation coupled to multi-angle light scattering (CF3-MALS).

This application note demonstrates a sample preparation procedure for using the Empore C18 SPE cartridge for the extraction of the THC metabolite, THC-COOH, from urine samples.

Accurate detection of HAAs is paramount for the prevention of over oxidation, while still managing enough water sanitation to eliminate water-borne pathogens.