Application Notes: General

High-capacity sorptive extraction with GC–MS enables trace analysis of odorants and chlorophenols in water, combining ppt sensitivity with full automation.

Trap-enhanced SPME Arrow analysis improves aroma profiling in food, enabling better peak shape, greater analyte coverage, and a wider concentration range.

John Yates’ lab is using MOBILion’s Parallel Accumulation Mobility Aligned Fragmentation (PAMAF) technology to enhance the DeGlyPHER workflow, which enables detailed, site-specific analysis of N-glycosylation in viral spike proteins such as SARS-CoV-2. This method combines sequential deglycosylation with high-sensitivity LC-MS to quantify glycan occupancy and processing, offering insights into the relationship between glycosylation and immune response. DeGlyPHER has been applied to over 200 vaccine candidates, including those for HIV, influenza, and Ebola, advancing understanding of glycoprotein-based immunogen design. This executive summary explains how DeGlyPHER is transforming vaccine development in real time, driving progress toward more effective and consistent immunization strategies, and delivering a more sensitive and high-throughput approach compared to traditional glycoproteomic methods.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

This non-IP-RP method, using ammonium bicarbonate as mobile phase additive, is highly sensitive and suitable for the bioanalysis of therapeutic oligonucleotides.

This application with data from Roche Diagnostics confirms superior performance of bioinert-coated YMC Accura BioPro IEX SF columns for the IEX-MS analysis of mAbs.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

This application note provides you an optimum RP method for the DAR determination of a site-specific ADC using a widepore YMC-Triart Bio C4 column.

This SEC-MS method demonstrates the precise separation of a single-chain variable fragment from its drug-conjugate.

Experience high recoveries from the first injection! YMC Accura BioPro IEX SF columns provide excellent peak shapes for the ion-exchange analysis of mAbs.

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent in plastic with accuracy and sensitivity, providing reliable and reproducible runs for high throughput laboratories.

Discover how the PerkinElmer GC 2400™ Platform provides fast analysis and high reproducibility.

Read how the integrated HS-GC workflow allows a continuous optimization of the pneumatic values for ultimate precision in GC retention time.

Discover an optimized GC/MS approach for SVOC in complex matrices.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover the GC 2400™ Platform for analytical precision and robustness for fuel alcohol analysis over a wide range of sample concentrations.

HPLC is the method of choice for enhancing the purity of synthesized peptides. Here, a systematic and efficient workflow for scaling up peptide purification is shown.

In this study, the unique capabilities of a LC-UV/MS workflow to accelerate analysis are demonstrated in the identification of impurities related to GLP-1 analogs that underwent chemical and thermal stress conditions.

In this study, we present a QC-friendly LC-UV/MS workflow designed to alleviate the workload on analytical laboratories. Access to orthogonal mass data allows supporting labs to make quicker and more informed decisions during method development, reducing errors, and increasing overall productivity.

This method provides precise separation with sharp and symmetric peaks for the coordinating compounds of the kynurenine pathway.

As analytical methods like high-performance liquid chromatography (HPLC) evolve, it becomes increasingly complex for labs to balance performance, price, and support. This infographic, based on independent LCGC International surveys commissioned by Agilent Technologies, reveals evolving end-user preferences, top performance drivers, and brand rankings in reliability and cost-efficiency.

Learn how MRR simplifies chiral analysis of raw materials like alaninol—no columns, no standards, and no derivatization required.

An LC-MS/MS method was developed to quantify C1–C4 PFAS in water, using direct injection to improve accuracy and reduce contamination in testing.

An LC–MS/MS method for detecting and quantifying EpODEs and DiHODEs in rat plasma using oxylipin standards from α-linolenic acid (ALA) and γ-linolenic acid (GLA).

Achieve >99% spectral accuracy and sub-mDa precision on standard LC/MS systems. Learn how MassWorks™ enables confident formula ID—no high-resolution MS required.