Application Notes: General

Magic mushrooms, once taboo, have recently experienced a renaissance. This new awakening is partially due to new findings that indicate the effects of psilocybin, and its dephosphorylated cousin psilocin may produce long lasting results for patients who might be struggling with anxiety, depression, alcohol and drug abuse, and post-traumatic stress disorder. Hamilton Company has developed a methodology for the isolation and identification of 5 common psychedelic compounds used in the potential treatment of disease. The PRP-1 HPLC column resin remains stable in the harsh alkaline conditions ideal for better separations.

Top quality materials and skilled workmanship ensure Hamilton syringes consistently deliver the highest possible performance for reliable analyses. With proper care and handling, Hamilton syringes provide unsurpassed performance year after year. This guide covers daily syringe use along with safety information and troubleshooting tips.

The G protein-coupled receptors (GPCR) are found throughout the entire body and have shown significance in the development of new therapeutic treatments. Isolation of seven classic GRPC peptides initiating in the GI tract highlights the benefits of using the polymer-based PRP-3, a reversed-phase resin. The covalent bonds found in the PRP-3 exhibit advantageous interactions between the biological π bonds found in the peptides and the available aromatic benzyl rings of the resin.

This application note demonstrates the superior resolution and recovery of Agilent AdvanceBio SEC 500 Å columns when compared with competitor products for AAVs.

This app note describes a non ion-pairing reversed-phase LC/MS method for highly modified ASOs, DNA, sgRNA, and siRNA ranging from 14- to 103-mer oligonucleotides.

This application note demonstrates a liquid chromatography/quadrupole time-of-flight mass spectrometer (LC/Q-TOF MS) workflow for the identification and characterization of therapeutic peptides.

An optimized liquid chromatography (LC) method offers improved impurity separation, no batch reproducibility issues, and is unaffected by changes in gradient delay volume settings.

Frontage laboratories wanted to improve the efficiency and quality of their operations and invest in ways to streamline their workflows. They implemented Waters NuGenesis™ Lab Management System (LMS) to progress their digital transformation journey and combine synergistic data, workflow, and sample management capabilities to support the entire product lifecycle from discovery through manufacturing.

Discover the principles, technologies, and myriad of benefits arising from the interconnected nature of networked LC-MS systems within analytical laboratories. Learn how LC-MS systems can empower you in your lab to excel in optimizing data generation and enhance overall efficiency.

Shandong Loncom Pharmaceutical Co. implemented NuGenesis LMS to help with generation of reliable and compliant production data, address electronic data management challenges, achieve accurate and efficient sample tracking, and manage increasing amounts of data. Learn more about how NuGenesis™ LMS enables labs to collect, record, and analyze experimental data for improved operational efficiency and data accuracy.

This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.

Now there's an single-purpose HPLC with a simplified UI that makes it possible for anyone to perform HPLC testing with a sinple one-button pass/fail test function.

Welcome to our comprehensive selection of High-Performance Liquid Chromatography (HPLC) cartridges. Designed for precision and reliability, our cartridges cater to diverse analytical needs, ensuring optimal performance in your laboratory processes.

The solution is an automated reaction monitoring system capable of unattended sampling, identification, and quantification of reaction components via HPLC. Axcend system is the only separations Process Analytical Technology (PAT) system that’s small enough to be placed in a hood or immediately adjacent to the reaction vessel.

Application Notebook highlighting Liquid Chromatography techniques commonly used for monitoring Critical Quality Attributes (CQAs) in Bioprocessing Applications

This application note demonstrates how THF mobile phases can be replaced to implement greener, safer, and less toxic SEC methods for polymer characterization.

This application note highlights the benefits of the LipiFiltr® cartridge for multi-class, multi-residue pesticide analysis in complex, high-fat samples.

Agilent and Scitara are collaborating not only to increase the efficiency of laboratory processes, but to enable customers to leverage the value of the data for various stakeholders. This paper will present an ecosystem designed to support enterprises in accelerating data workflows and improving data availability for researchers, lab analysts, and data scientists.

This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real-time.

This application note summarizes key SIFT-MS results presented in a peer reviewed article entitled “Unreported VOC Emissions from Road Transport Including from Electric Vehicles.” Learn how the Wolfson Atmospheric Chemistry Laboratory at the University of York used SIFT-MS for VOC analysis in its platform to experimentally verify that motor vehicle screen wash is a significant unreported source of VOC emissions (especially for ethanol and methanol).

Method detection limits (MDLs) have been determined for the newly regulated HON (Hazardous Organic NESHAP (National Emission Standards for Hazardous Air Pollutants)) compounds, which validate selected ion flow tube mass spectrometry (SIFT-MS) as an effective solution for measuring these toxic volatile organic compounds (VOCs) and other environmental pollutants in ambient air, whether at the fenceline or in a mobile setting. SIFT-MS offers unparalleled speed, sensitivity and ease of use for environmental monitoring applications.

A comparison made between a stainless steel hardware column and an INERT column using the same lot of HALO 90 Å C18, 2.7µm results in tailing factor and area improvement using the HALO®INERT column.

Using HALO®Elevate C18 and a high pH mobile phase obtains a great separation of drugs of abuse and metabolites without the use of a specialized stationary phase.

A 16 mer ssDNA poly dT oligonucleotide was analyzed under UV conditions on a HALO®OLIGO C18 column. The results revealed smaller peaks before and after the primary peak of interest.