Application Notes: General

This application brief describes the use of an EpicTM C18 to analyze three ginsenosides using a method based on the Chinese Pharmacopeia.

See how the µPAC™ capLC LC–MS column can help increase sample throughput, and at the same time maintain the highest separation efficiency and sensitivity.

See how the µPAC™ capLC LC–MS columns can contribute in the characterization of the glycosylation pattern of therapeutic enzymes.

Learn how to simplify the connectivity from your µPAC™ column to your mass spectrometer, with Nanospray Flex source. Only two connections, from column to emitter.

The µPAC™ GEN2 nanoLC columns are specifically designed to further improve your LC–MS results. More IDs and higher reproducibility for more confidence in your data.

The µPAC™ Limited Sample Amount column is designed for ultrahigh sensitive separation performance for the smallest sample amounts, typically less than 20 ng of content.

Learn about the µPAC™ trapping columns, and see how they can help sample preconcentration in nanoLC–MS. Pick your preferred workflow, forward or backflush, and run.

This application note describes the drug-to-antibody determination of brentuximab vedotin using a ternary gradient with isopropanol as third channel organic modifier.

A flexible, automated workbench for determination of fatty acid content of a range of sample types, automating sample prep and analysis with a simple user interface.

Advance your oligonucleotide work, from sample preparation to analysis and purification.

This technical note discusses 2' cleavage and RNA sample preparation prior to trityl-on Clarity QSP cartridge or high-throughput purification.

Using the Clarity OTX extraction protocol vendor recommendations, we have demonstrated its use to develop a method for the extraction of therapeutic oligos from plasma.

Common frequently asked question for oligonucleotides. This includes questions about characterization to purification and from sample preparation to LC separation.

Clarity QSP provides an alternative trityl-on approach for separating truncated sequences and synthetic contaminants from the protected full-length sequence. By incorporating a polymeric sorbent with a unique buffer formula, aborted fragments and synthetic contaminants are removed during sample loading offering a departure from the traditional RPC mechanism. Multiple buffers and gradient elutions are eliminated, thereby making Clarity QSP a 3-step product for trityl-on oligonucleotide purification.

As synthetic oligonucleotide therapeutics move through the drug-development path, the need for TK and PK/PD studies in drug discovery and development has increased.

Simple, quick, effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit based on mixed-mode ion-exchange SPE.

To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.

Trityl-on methodologies for the analysis of crude synthetic oligonucleotides has many benefits however depurination during trityl-on methodologies can lead to nucleic acid damage. This technical note explores a new trityl-on procedure that minimizes the risk of depurination.

Extraction of Oligo therapeutics from biological samples for LC/MS bioanalysis.

Fortis Technologies has launched a new application note on the analysis of cannabinoids. A sample of twelve cannabinoids was analyzed by LC–MS in 7 minutes.  

Learn how to convert your GC carrier gas from helium to hydrogen with this step-by-step guide to avoid the increasing cost of helium.