Application Notes: General

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.

This application note summarizes a validated procedure developed by the US Food and Drug Administration (FDA) for the measurement of 16 PFASs in food using a QuEChERS sample preparation approach.

Meeting detection challenges presented by nitrosamine impurities Determination of NDMA and nitrosamine impurities using triple-quadrupole LC/MS Determination of genotoxic impurities in ranitidine APIs and drug products

This application note shows how to obtain a fast separation of cannabidiol and melatonin in a sleeping aid with excellent peak shapes using a YMC-Triart C18 column.

Antec Scientific ALEXYS FDG analyzer for seamless QC of the radiolabeled FDG and its by-products according to the European and US Pharmacopeia monographs.

SEC with multi-angle light scattering provides absolute characterization, in solution, of proteins, peptides, nucleic acids, polysaccharides, and bionanoparticles.

To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape in large molecule reversed-phase applications.

This application analyzes how to reduce peak widths by adjusting the flow rate for intact and reduced NIST mAb when using a bioZen WidePore C4 LC column.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection and separation of low-level impurities for subunit analysis.

Multiple C4 LC columns are compared to determine which provides the necessary separation of the impurity and avoids any spectral overlap in the MS detector.

bioZen WidePore C4 is built upon core-shell technology with bioinert hardware to offer optimal particle and pore-size morphology for high reproducibility and resolution.

Best practices with water in the analytical lab FAQs about lab water Lab water preparation optimized

To increase the resolution, this application evaluates and optimizes the gradient program when using a bioZen WidePore C4 LC column.

This technical overview describes the automated preparation of calibration solutions offered by the injector program available with Agilent autosamplers.

This technical overview describes the automated preparation of calibration solutions offered by the injector program available with Agilent autosamplers.

This application note presents a novel study of coffee aroma profiling by analyzing volatile organic compounds (VOCs) emitted at a series of progressively higher temperatures.

With Antec Scientific’s new ground-breaking µ-PrepCell-SS, electrochemical reduction of disulfide bonds in peptides, proteins, mAbs, and other biopharmaceuticals becomes possible routinely in LC-MS workflows. • Fast and efficient reduction of S-S bonds • Robust on-line reduction in top-down and bottom-up Proteomics • Reagent free, no interfering DTT or TCEP, ideal for HDXMS • Superior peptide sequencing and S-S bond assignment

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• Why hybrid systems are the wrong approach • The why, what, and how of CDS audit trail review • Understanding the Lifecycle Approach for Analytical Procedures