Application Notes: General

This application note describes the improved identification of pharmaceutical low-level impurities when using SFC and UHPLC as orthogonal separation modes.

Discover an automated sample preparation system that effectively and efficiently extracts diquat and paraquat from drinking water via EPA Method 549.2.

Teach a virtual chromatography lab with LC simulation software. See how one chemistry professor replaced hands-on labs with online experiential learning.

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

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From siRNA to mRNA to DNA, separating full length product from impurities can be challenging. Taking into consideration the nature of the oligonucleotide you are interested in, you will be able to make informed choices about what approach to use to characterize or purify your molecule.

This application note describes the company’s range of oligonucleotide columns and oligonucleotide standards.

This application note demonstrates the suitability of the company’s stationary phases to separate deprotected RNA and DNA oligonucleotides of different sizes.

A method using the company’s system to purify long-and short-term oligonucleotides is described.

This application note demonstrates direct ion-pair reversed-phase online desalting using 2D -LC for the analysis of oligonucleotides.

Polymeric strong anion exchange methods such as PL SAX are suitable for anion exchange and purification of oligonucleotides. At elevated temperatures, enhanced mass transfer increases the resolution for larger oligonucleotides. Working at higher PH values enables resolution of phosphodiester and phosphothioate forms of the oligonucleotide.

IONICON PTR-TOF real-time breath gas analyzers are deployed for finding a quick, non-invasive test to identify a SARS-CoV-2 infection in exhaled breath.

Key bourbon odorants with flavor dilution factor 201 found by solventless extraction and GC–MS/O-Aroma Dilution Analysis. Data analysis and AEDA-like reporting is shown.

GC/MS system capabilities can be expanded using versatile technology. A new multi-mode pyrolyzer addresses analytical challenges and increases efficiency.

This application describes the purification of paracetamol from a crude sample in early-stage drug discovery. Outstanding purity (>99%) and recovery (>95%) are achieved.

This application describes the purification of paracetamol from a crude sample in early-stage drug discovery. Outstanding purity (>99%) and recovery (>95%) are achieved.