Application Notes: General

This application note shows how to achieve narrow peaks and high sensitivity by optimising the AEX separation of phosphorothioate oligonucleotides (PS) in only 5 steps.

In this application note eight intact proteins in the protein mix MSRT2 are analysed by Micro-LC–MS using an YMC-Triart Bio C4 capillary column.

This application note using YMC-Triart Bio C4 shows a robust separation at high temperatures of 3 commercially available MAbs: Ofatumumab, Palivizumab, and Panitumumab.

In this application YMC-Triart Bio C4 was used to analyse a reduced monoclonal antibody and a reduced ADC mimic with formic acid or TFA as additives.

Note discusses how labs can protect themselves against spreading COVID-19 among its employees.

Recombinant mAbs tend to be unstable and susceptible to modification/degradation. These mAbs need to be identified/monitored for successful drug development. New advanced LC–MS workflows have been developed to meet such needs.

This application note describes the isolation of target compounds from Rhodiola rosea using online mass-based 2D-LC purification to quickly achieve the highest purity.

In reversed-phase liquid chromatography, increasing the column temperature usually results in a decrease in analyte retention. Will this cause problems if a method does not call for control of the column temperature but the room temperature of the laboratory environment changes?

“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography seen at Pittcon and other venues in the past 12 months.

More and more manufacturers are embracing multi-attribute method, which simplifies biopharmaceutical product quality testing, and facilitates the measurement and monitoring of critical quality attributes.

An HCP analysis workflow including the Agilent AssayMAP Bravo platform for automated sample preparation, 6545XT AdvanceBio LC/Q‑TOF for LC-MS/MS analysis

This whitepaper demonstrates the features and benefits of owning an Ultivo LC/TQ in terms of actual tangible benefits to your laboratory operations.

A method describing the detection of 12 potentially mutagenic nitrosamine impurities found in sartan drugs using the Ultivo LC/TQ

FFF-MALS-DLS provides the detailed characterization of nano-pharmaceuticals that is essential for development and regulatory filing.

Stay one step ahead of water regulation, QSight™ LC–MS/MS offers sensitivity, selectivity, and robustness while saving time on maintenance and cleaning operations for your testing.

Use interactive calculators included in this whitepaper to determine the incremental economic value of the Agilent 1260 Infinity II Prime LC and InfinityLab LC/MSD iQ.

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

The Zebron ZB-PAH-EU and ZB-PAH-SeleCT offer unparalleled performance of targeted selectivity for PAHs in food, environmental, electronics, and fuel industries.

In this application, we look at purgeable volatile organic compounds by GC–MS using Zebron™ ZB-624PLUS™ GC columns.

In this application, we look at residual solvents per USP 467 using Zebron™ ZB-624PLUS™ and ZB-WAXPLUS™ GC columns.

How to reduce FAME run times by up to 75% and improve the separation of cis/trans FAME isomers while remaining compatible with AOAC, AOCS, and IOC regulatory methods.

In this application, we look at the fast analysis of alcohol-based sanitizers by GC–FID using Zebron™ ZB-WAXPLUS™ GC columns.