Application Notes: LC-MS

High resolution separation of 24 PFAS compounds using the HALO® PFAS Delay column coupled with the HALO® PFAS analytical column.

Rapid and high-resolution analysis of PFAS compounds across EPA methods 537.1, 533, and 8327, using the new HALO® PFAS delay and analytical columns.

To improve the chromatography of PFAS and other environmentally concerning chemicals, application-assured HPLC columns deliver high efficiency and robust analysis.

In this application note high resolution SCX was coupled directly to an ultrasensitive online native MS using YMC’s BioPro IEX SF to analyse mAb charge variants.

This note demonstrates a novel, easy-to-use, intelligent tandem nanoLC-MS setup capable of 100% MS use that is compatible with the Sonation double-barrel nano ESI source.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

A fast and efficient SPE sorbent, Strata-X PRO, was chosen to extract a panel of acids, neutrals, and bases from plasma to reduce the number of steps in the clean-up.

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Efficient and reproducible separation of thymidine oligomers is achieved using an ion-pair reversed phase shallow gradient method with the Avantor® ACE® Oligo column.

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

Our compilation of Avantor® ACE® applications for key analyte classes in cannabis products and potential contaminants provides technical support for this key expanding area.

The TSKgel UP-SW Aggregate 30 nm column demonstrates the advantages of using a larger pore size when analyzing high-order aggregates and large molecules.

To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape in large molecule reversed-phase applications.

This application analyzes how to reduce peak widths by adjusting the flow rate for intact and reduced NIST mAb when using a bioZen WidePore C4 LC column.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection and separation of low-level impurities for subunit analysis.

Multiple C4 LC columns are compared to determine which provides the necessary separation of the impurity and avoids any spectral overlap in the MS detector.

CE–MS can help address limitations associated with traditional LC–MS CE–MS provides fast separations with low sample consumption and no carry over

- Conventional light scattering comes with various limitations - New light scattering technology benefits protein/polymer characterization

In this study we demonstrate the benefits of the Thermo Scientific™ Orbitrap Exploris™ 240 LC–MS/MS for intact biopharmaceutical analysis under native conditions.

In this application note we evaluate the benefits of Real-Time Search for SPS MS3 (Orbitrap Eclipse MS) to enhance TMT quantification accuracy and proteome coverage.

In this application note we discuss the AcquireX workflow using the Orbitrap ID-X for detection and quantitation in non-targeted, multiresidue LC–MS pesticide profiling.