Application Notes: LC-MS

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

A fast and efficient SPE sorbent, Strata-X PRO, was chosen to extract a panel of acids, neutrals, and bases from plasma to reduce the number of steps in the clean-up.

This application focuses on developing a rapid SPE and LC-MS/MS method for the quantitative analysis of uracil and its two homologues from human serum.

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

Our compilation of Avantor® ACE® applications for key analyte classes in cannabis products and potential contaminants provides technical support for this key expanding area.

The TSKgel UP-SW Aggregate 30 nm column demonstrates the advantages of using a larger pore size when analyzing high-order aggregates and large molecules.

To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape in large molecule reversed-phase applications.

This application analyzes how to reduce peak widths by adjusting the flow rate for intact and reduced NIST mAb when using a bioZen WidePore C4 LC column.

Comparing core-shell superficially porous to fully porous particles to determine efficiency required for detection and separation of low-level impurities for subunit analysis.

Multiple C4 LC columns are compared to determine which provides the necessary separation of the impurity and avoids any spectral overlap in the MS detector.

CE–MS can help address limitations associated with traditional LC–MS CE–MS provides fast separations with low sample consumption and no carry over

- Conventional light scattering comes with various limitations - New light scattering technology benefits protein/polymer characterization

In this study we demonstrate the benefits of the Thermo Scientific™ Orbitrap Exploris™ 240 LC–MS/MS for intact biopharmaceutical analysis under native conditions.

In this application note we evaluate the benefits of Real-Time Search for SPS MS3 (Orbitrap Eclipse MS) to enhance TMT quantification accuracy and proteome coverage.

In this application note we discuss the AcquireX workflow using the Orbitrap ID-X for detection and quantitation in non-targeted, multiresidue LC–MS pesticide profiling.

Microfluidic lab-on-a-chip devices offer new solutions for analytical scientists. The Column spoke to Dietlev Belder from the University of Leipzig, Germany, about the latest developments in this evolving area of research.

PharmaFluidics’ μPAC capLC is evaluated for different user needs ranging from 12 samples per day in comprehensive mode to 65 samples per day in throughput mode.

PharmaFluidics’ μPAC capLC is evaluated for different user needs ranging from 12 samples per day in comprehensive mode to 65 samples per day in throughput mode.

Overall gain in performance and increase in detection sensitivity that can be achieved for the separation of plant metabolite extracts by using µ¬PAC columns.

Reveal more in your food. Using QSight LC–MS/MS to get a fast, selective, and sensitive multi-residue method for the determination of 136 pesticides in pepper.