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ChromTalks: The Benefit of Hindsight in Chromatography Characterization of Monoclonal Antibodies Using In-Line SEC-ESI-MS Optimizing LCs During a Pandemic Where Has My Efficiency Gone?Advancing the Development of New Pharmaceuticals

ChromTalks: The Benefit of Hindsight in ChromatographyCharacterization of Monoclonal Antibodies Using In-Line SEC-ESI-MSOptimizing LCs During a PandemicWhere Has My Efficiency Gone?Advancing the Development of New Pharmaceuticals

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View More Liquid Chromatography (LC/HPLC)Gas Chromatography (GC)Sample Preparation Mass Spectrometry Pharmaceutical Analysis Environmental Analysis Food and Beverage Analysis

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Spotlight

ChromTalks: The Benefit of Hindsight in Chromatography
Characterization of Monoclonal Antibodies Using In-Line SEC-ESI-MS
Optimizing LCs During a Pandemic
Where Has My Efficiency Gone?
Advancing the Development of New Pharmaceuticals

TopicsSee All >

Liquid Chromatography (LC/HPLC)
Gas Chromatography (GC)
Sample Preparation
Mass Spectrometry
Pharmaceutical Analysis
Environmental Analysis
Food and Beverage Analysis

About
Advertise
Author Guidelines
Contact Us
Editorial Staff
Editorial Advisory Board
Ethics Policy
Do Not Sell My Personal Information
Privacy Policy
Permissions
Terms and Conditions

Application Notes

Deep Proteome Coverage on HeLa Lysate Using a bioZen™ Fractionation Column for High pH (Basic Reversed-Phase) Fractionation in Combination with a bioZen Nano Peptide XB-C18 Column for Nano Flow LC–MS

May 04, 2021

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We demonstrate how to achieve deep proteome coverage on HeLa cell lysate using a high pH reversed-phase fractionation strategy in combination with nano flow LC–MS.

bioZen High pH Fractionation Application Guide

May 04, 2021

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The bioZen high pH fractionation HPLC column provides superior performance using titanium hardware, minimizing nonspecific adsorption for peptide identifications.

Increasing Sensitivity by Scaling Down from Micro- to Nano-Flow LC

May 04, 2021

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In this technical note we explore column miniaturization effects attained by reducing column ID from 300 μm to 75 μm and its effects on sensitivity.

Column Reproducibility and Robustness Using the bioZen Nano 2.6 μm XB-C18 LC Column

May 04, 2021

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In this application we show reproducible results across multiple columns as well as the robust ability of the bioZen 2.6 μm XB-C18 column after 100 injections.

Application Note: Native Online HIC–MS Analysis of mAbs

April 30, 2021

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Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

Charge Variant Analysis of 28 mAbs

April 30, 2021

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Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

Leuprorelin Analysis Using YMC-Triart Bio C18

April 30, 2021

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In reference to the Japanese Pharmacopeia, YMC-Triart Bio C18 was used to analyze the peptide leuprorelin (GnRH analogue) and separate it from its degradation products.

Analysis of Bevacizumab by SEC–MALLS

April 30, 2021

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In this application note, YMC’s dedicated SEC column for antibodies, YMC-SEC MAB, has been used to develop a method for bevacizumab using MALLS detection.

Application Note: Native Online SCX-MS Analysis of mAbs

April 30, 2021

Sponsored Content

Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants

LC–HRMS Analysis of the ASO Mipomersen

April 30, 2021

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Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column ensuring symmetric peaks, high sensitivity, and no carryover effects.