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Analysis of N-Nitrosodimethylamine (NDMA) Impurity in Rantidine Products Using SIFT-MS
February 21st 2024Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods. This application note describes the headspace-SIFT-MS analysis of ranitidine products which achieves a limit of quantitation of 2 ng g-1 for NDMA in 500 mg of drug product.
Real-Time Monitoring of Bioreactor Production Processes Using SIFT-MS
February 21st 2024The ability of SIFT-MS to monitor critical volatile organic compounds (VOCs) produced by a bioreactor in real-time at low parts-per-billion by volume (ppbV) concentrations is demonstrated. This application note presents the results of a pilot-scale feasibility study conducted over several weeks, demonstrating the utility of SIFT-MS for maximizing production outcomes.
Simple Rapid Analysis of Packaging for Volatile MOSH and MOAH Contaminants
February 21st 2024This application note demonstrates that automated headspace-SIFT-MS analysis has the potential to screen larger sample numbers for the volatile MOH fraction, providing a rapid indication of packaging material contamination. As benzene has also recently been found to be problematic in commercial products, Headspace-SIFT-MS can screen over 220 samples per day for volatile MOSH and MOAH compounds – nearly seven-fold more samples than the routine liquid and gas chromatography method.
Revolutionary Productivity For Volatile Residue and Impurity Analysis (Feb 2024)
February 21st 2024This application note describes a scenario in which Syft Tracer replaces five chromatography systems and still has significant available sample capacity. Next gen SIFT-MS provides rapid, chromatography-free workflows which revolutionize volatile compound analysis.
High-Throughput Quantitative Analysis of Benzene in Personal Care Products Using Headspace-SIFT-MS
February 21st 2024This application note demonstrates the speed of headspace-SIFT-MS methods for the analysis of benzene in personal care products (PCPs). In less than three hours, seven-point calibration curves can be generated and accurate quantification of benzene in PCPs achieved. SIFT-MS provides rapid, sensitive, and robust analysis of benzene and other contaminants in a variety of commercial products. Integration with a headspace autosampler enables rapid screening of hundreds of samples per day.
Cannabinoid Isomer Separation Utilizing an Analytical Quality by Design (AQbD)
February 19th 2024Cannabinoid separation can be difficult with the presence of coeluting isomers. This application shows how a combination of LabSolutions MD (Method Development) software and powerful i-PDeA technology can help determine the optimal method for cannabinoid separation and deconvolute remaining co-eluting peaks after optimization.
Analysis of 28 Common PFAS Compounds using a Compact Single Quadrupole LCMS
February 19th 2024This application showcases how a compact, affordable single quad LCMS can be easily integrated into existing laboratories for measurement of PFAS in diverse samples where adherence to regulated methods (e.g., EPA 533, 537.1, and 1633) is not required, or samples where expected concentrations are larger than sub ppb levels.
Determination of Nitrosamine Impurities Using the Agilent 6495D Triple Quadrupole LC/MS System
February 9th 2024This application note describes the evaluated quantification performance of eight nitrosamine impurities using an Agilent 6495D triple quadrupole LC/MS (6495D LC/TQ) system coupled with an Agilent 1290 Infinity II bio LC system and Agilent APCI source.
Flash Characterization of Antibodies via Microdroplet Reactions in an Unmodified Jet Stream Source
February 9th 2024Recently, attention has been drawn to the use of microdroplet reactions for antibody analysis. The NIST IgG1 mAb was used to optimize microdroplet reaction conditions on two reactions, IdeS cleavage and disulfide bond reduction, using the Agilent Jet Stream ESI source.
High-Sensitivity Oligonucleotide Analysis Using Ion-Pairing-Free HILIC and TOF LC/MS
February 9th 2024This application note presents an alternative method using time-of-flight liquid chromatography/mass spectrometry (TOF LC/MS) and hydrophilic interaction chromatography (HILIC) that enables accurate and repeatable analysis of diverse oligonucleotides without using ion-pairing reagents.
mAb Characterization Process Innovations
February 8th 2024Earlier assessment of molecules provides valuable insights into the manufacturing developability of molecules, reducing the need for unnecessary experimentation. The Intabio ZT system has the potential to make in-depth characterization of biopharmaceutical product charge variants quicker and more efficient to meet demanding timelines during early-phase clinical development.
Trace Elements in Fish Oil and Fish Oil Supplements
January 23rd 2024The U.S. Food and Drug Administration and the EPA advised pregnant women and those who might become pregnant to avoid certain fish known to be high in mercury. This study will investigate trace element concentrations including heavy metal concentrations in different types of fish and fish oil supplements available from local markets in New Jersey.
Heavy Metals in Food and Beverages
January 23rd 2024In this podcast, we will look at different sources of potential heavy metal exposure and their concentrations in a variety of food products including fish, and beverages. In addition to the original research presented, we will compare other historical studies and public health findings to showcase the sources and concentrations of various heavy metals found in the food and water supply in order to build a more complete picture of heavy metal exposure through food and beverages.
Heavy Metal Exposure in Common Childhood Food Staples - The Peanut Butter and Jelly Studies
January 23rd 2024In this study, dried fruit samples (organic and regular raisins, sultanas and currants) and bread spreads (from different nuts and seeds; i.e. peanuts, almonds, sunflower etc.) were purchased from stores in the US, UK and Germany. Samples were digested using microwave digestion and tested by ICP-MS to determine heavy metal contamination and potential exposure.
Heavy Metal of Hot Sauce and Chili Powder
January 23rd 2024Spices and hot sauces were purchased at dollar stores, farmer’s markets, chain stores, and online. Samples included ‘organic’ products. Cryogenic grinding and microwave digestion were employed in sample processing prior to ICP-MS analysis to determine the presence and level of heavy metal contamination and adulteration.
Heavy Metals in Pet Food: Changes in Heavy Metal Contamination in Pet Food Over the Past Decade
January 23rd 2024This new updated study revisits pet food brands first analyzed in 2009 and looks at new brands which that emerged after the 2007 pet food crisis and later enactment of FSMA to see if heavy metal contamination has significantly changed in the decade since the first study.
Breaking Down the Microplastics Problem with Pyrolysis-GC/MS
January 23rd 2024Professor Wan-Tang (Grace) Chen of the University of Massachusetts Lowell accepted our invite to participate in a virtual Q&A session. Dr. Chen directs the Plastics & Environment Research Laboratory at the university and was gracious enough to share what her team is working on, and how they’re leveraging the Pyrolysis-GC/MS technique in novel microplastics research.
Heat and High pH Forced Degradation of Antibodies on a Biozen dSEC-2 Column
January 22nd 2024This application note demonstrates the applicability of the Biozen dSEC-2 column in understanding the biophysical integrity monoclonal antibodies and related proteins. The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions which is a known challenge when working with more hydrophobic hybrid particles for these studies.