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This fourth article in a series curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at the University of Valladolid (Spain) discusses the importance of the red dimension within the white analytical chemistry (WAC) framework, and presents the Red Analytical Performance Index (RAPI) tool as a critical advancement for harmonizing analytical performance assessment.

In the first part of this roundtable discussion focused on the experiences, challenges, and contributions of Women in Chromatography, LCGC International spoke to Noor Abdulhussain, Lotte Schreuders, and Mimi den Uijl—co-founders of the Sisters in Science initiative—about their movement, which was started in 2021.

Researchers in Malaysia examined the effects of Kelulut honey on metabolic syndrome (MetS)-induced osteoporosis in male rats fed a high-carbohydrate high-fat (HCHF) diet, with chemical profiling of the honey was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods.

This third in the series of five articles curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at University of Valladolid (Spain)focuses on the blue dimension of white analytical chemistry (WAC), a concept introduced to complement green analytical chemistry (GAC) by incorporating analytical performance (red) and practical and economic aspects (blue).

LCGC International spoke to the author of the study, John Mommers, who is a scientist of chromatography and mass spectrometry (MS) at Envalior, about the key challenges faced when developing MASSISTANT and how it can be integrated in GC-EI-MS workflows.

Green analytical chemistry (GAC) has emerged as a critical discipline focused on minimizing the environmental footprint of analytical methods. This second article in this week's series curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at University of Valladolid (Spain) traces the evolution of GAC through the development of its key greenness assessment metrics.

LCGC International spoke with Giorgia Purcaro, Ilaria Belluomo, and Katelyn Perrault Uptmor on advancing equity in chromatography, highlighting cultural shifts, practical strategies, and resources to support DEI success and leadership.

LCGC International spoke to Maria Hayder, corresponding author of a recently published paper (1) discussing a novel workflow for nanoplastic analysis in environmental water samples, incorporating asymmetrical-flow field-flow fractionation coupled with multiangle light scattering (AF4-MALS) and pyrolysis–gas chromatography-mass spectrometry (Py-GC-MS) in an offline combination.

A recent study examined a new method to optimize raisin production by demonstrating how pretreating grapes with extra-virgin olive oil (EVOO) before dehydration can significantly improve the retention of beneficial phenolic compounds during raisin production and storage.

Researchers at the Université de Montréal evaluating the pharmacokinetics and pharmacodynamics of a single oral dose of trazodone in laboratory rabbits determined plasma concentrations of the drug with high performance liquid chromatography-mass spectrometry (HPLC-MS).

This week, LCGC International published a variety of articles on hot topics in separation science. From several interviews around the role chromatography is playing in forensic analysis to using multidimensional liquid chromatography (LC) in the development of a new Python tool, we’ve highlighted some of the most popular articles that were published this week.

Researchers at the University of Johannesburg investigated the potential of orotate phosphoribosyl transferase (URA5) to detoxify patulin in apple juice under controlled condition, with liquid chromatography-mass spectrometry (LC-MS) used to monitor degradation.

Discover how to optimize LC×LC orthogonality for organic micropollutants analysis, enhancing method development with a new open-source Python tool.

As part of “From Sample to Verdict,” LCGC International sat down with Noemi Procopio, who is the Principal Investigator of the "Forens-OMICS" team and a Senior Research Fellow in Forensic Science at the University of Central Lancashire to talk about her team’s work. In Part III of our conversation with Procopio, she discussed how her team analyzes bone samples for post-mortem interval (PMI) estimation. In the final part of our conversation, Procopio discusses what a routine omics-based PMI assay could look like in the future.

Researchers used orthogonal analytical methods, including anion-exchange chromatography (AEC), to investigate the impact of successive freeze/thawing cycles on the stability of the Covid vaccine ChAdOx1-S/nCoV-19.

Researchers in Japan characterized heat-induced chemical modifications and changes in the molecular size distribution and structure of liquid transfer proteins, using size-exclusion chromatography (SEC) and liquid chromatography-mass spectrometry (LC-MS).

As part of our “From Sample to Verdict” series, LCGC International sat down with Furton to discuss his team’s work in the Global Forensic and Justice Center. In Part II of our conversation with Furton, he discusses the applicability of SPME in other forensic applications, as well as the limitations of using SPME.

As part of “From Sample to Verdict,” LCGC International sat down with Noemi Procopio, who is the Principal Investigator of the "Forens-OMICS" team and a Senior Research Fellow in Forensic Science at the University of Central Lancashire, to talk about her team’s work. In Part I of our conversation with Procopio, she discussed the development of the Forens-OMICS approach and how her team estimates PMI using metabolomics, proteomics, and metabarcoding. Part II dives deep into post-mortem interval (PMI) estimation and how bone proteomics can be used to accurately estimate PMI.

Discover how a multi-metric orthogonality score enhances LC×LC separation quality, reducing bias and improving method development in chromatography.

LCGC International sat down with Daniel Petras to discuss persistent challenges in non-targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolite annotation, where only a small fraction of acquired spectra match existing libraries, and how the multiplexed chemical metabolomics (MCheM) workflow introduces functional group-specific derivatization to generate orthogonal chemical data.

As part of “From Sample to Verdict,” we present a compilation of the latest news articles and peer-reviewed content that highlight the utility of chromatography in forensic analysis.

Petr Vozka highlights how GC×GC–TOF-MS reveals time-dependent chemical changes in fingerprints, enabling age estimation through chemometric modeling and advancing forensic timelines beyond traditional ridge pattern analysis.

LCGC International spoke with Ira Lurie, a professional lecturer at George Washington University in the USA, about his research using innovative chromatographic strategies to improve the specificity and efficiency of forensic drug analysis. He details the application of “flip-flop” chromatography using silica hydride stationary phases to alternate between reversed-phase and aqueous normal-phase separations without changing solvents. Lurie also highlights the use of derivative gas chromatography–vacuum ultraviolet spectroscopy (GC–VUV) to differentiate challenging synthetic cannabinoid isomers, emphasizing the critical legal and scientific importance of accurate isomer identification in forensic casework.

Ida Marie Marquart Løber explores postmortem interval estimation using UHPLC–QTOF-MS and machine learning, profiling rat tissue metabolites and outlining pathways for human adaptation toward objective, AI-driven forensic timelines.

As part of “From Sample to Verdict,” LCGC International sat down with Ed Sisco and Sarah Shuda, Research Chemists at NIST, to discuss the work that their groups are conducting that are helping to advance forensic analysis.