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This “Column Watch” installment reports on highlights from the 48th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2019), held June 16 to 20 in Milan, Italy.

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How does one meet the most demanding part of an analysis-sampling? A typical example is soil, which presents a twofold problem for the analyst: first, the selection of the sites where the samples are taken, and second, the reduction of a sample (for example, 1 kg) to the analysis aliquot size (for example, 10 μL). This paper describes the details of sampling issues.

Pharmaceutical Product Development (PPD) is expanding its bioanalytical laboratory in Richmond, Virginia, in an effort to enhance its ability to meet biopharmaceutical clients’ increasing research needs.

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Researchers from the University of Rome have developed a strategy for the identification of underivatized short peptides in urine using graphitized carbon black (GCB) solid-phase extraction (SPE) and liquid chromatography–mass spectrometry (LC–MS).

In an effort to better understand the current application potential of microscale liquid chromatography (micro-LC), I picked up a few recent review articles from the literature. What one immediately appreciates from glancing through the literature for such information, is that there are a lot of different configurations and alternative formats, which can be placed under the micro-LC umbrella.