LC–MS

In a recent study out of Central South University in Changsha, China, scientists tested different cosine similarity algorithms to test for illegal adulterants in drugs.

Here are the top five articles that the editors of LCGC International published this week.

In a recent study, scientists tested how effective dynorphin 1-17 peptides can be in treating chronic rhinosinusitis with nasal polyps (CRSwNP).

Webinar Date/Time: Thu, Apr 4, 2024 11:00 AM EDT

A recent study explores how chromatographic methods are being used to detect new psychoactive substances (NPS).

A recent study dissects a Chinese herbal medicine to determine why it is effective in treating polycystic ovary syndrome (PCOS).

A group of Canadian scientists recently measured how effective different solutions are in measuring ochratoxin A levels in flour samples.

Scientists from Hangzhou, China used ultra-performance liquid chromatography mass spectrometry and non-targeted metabolomics studies to help find treatments for colorectal cancer.

This article describes a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the analysis of coumarin in various tobacco matrices and electronic cigarette (E-cig) liquids, and highlights the importance of evaluating different MS/MS transitions of an analyte in complex sample matrices to overcome matrix effects. Matrix interfering components were separated from analyte using a C18 ultrahigh-pressure liquid chromatography (UHPLC) column with a larger inner diameter (3.0 mm, or 4.6 mm). Matrix suppressions on analyte responses were corrected by isotope dilution. Four different MS/MS transitions of coumarin were studied in each sample matrix to select a suitable MS/MS transition for analyte quantification based on matrix effects on each MS/MS transition. The method was validated using different tobacco matrices and E-cig liquids.

Webinar Date/Time: Thu, Mar 28, 2024 11:00 AM EDT

Scientists from Murcia, Spain recently created a new method for mycotoxin screening in human tissues using dispersive liquid–liquid microextraction and liquid chromatography–mass spectrometry.

Sara E. Kern and her team of the U.S. Food and Drug Administration (FDA) tested different analysis methods for rapidly screening for poppy seeds in food samples.

Webinar Date/Time: Tuesday and Wednesday, March 26 and 27, 2024 Morning Session: 9:30am - 12:00pm EDT Afternoon Session: 2:00pm - 4:00pm EDT

Webinar Date/Time: Airing 1: Wednesday, March 20, 2024 at 11AM EDT / 3PM GMT / 4PM CET Airing 2: Wednesday, March 20, 2024 at 2PM EDT / 1PM CDT / 11AM PST

The 18th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology will take place from 28–31 May 2024 in Leuven, Belgium.

Researchers from Nanjing University of Chinese Medicine leveraged ultrahigh-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) and network pharmacology to identify potential quality markers of three processed Qingpi products and elucidate their mechanism in liver disease treatment.

Researchers employed advanced chromatography and mass spectrometry techniques to unravel the chemical components and metabolites of Lingbao Huxin Dan, pinpointing its therapeutic potential for cardiovascular ailments.

Weronika Hewelt-Belka, an assistant professor at Gdańsk University of Technology in Poland, answers questions about her research analyzing GM3 gangliosides in human milk, elucidating their molecular distribution and dynamic changes throughout lactation.

The process was assisted by pH-dependent acid-base partitioning coupled with salting-out-assisted liquid-liquid extraction (LLE).

Using LC–MS in conjunction with QuEChERS extraction was demonstrated in this study to have the ability to monitor pesticide pollution in livestock breeding.

Scientists from Utah and Ireland recently created a liquid chromatography–mass spectrometry (LC–MS) analytical method capable of detecting phototoxins in essential oils.

LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.

A review of advances in mRNA analysis using LC and LC–MS.

Scientists in Xi’an, China have created a novel system for the analysis of cell membranes, based around haloalkane dehalogenase protein tag (HALO)-tag technology. Their research was published in Talanta.

In our first edition of “Inside the Laboratory,” Laura-Isobel McCall, PhD, an associate professor of chemistry at San Diego State University, discusses her group’s most recent work using “chemical cartography” in order to perform effective liquid chromatography–mass spectrometry (LC–MS) data acquisition.