LC–MS

"A well-prepared sample, a well-defined analytical goal, the appropriate use of accurate mass, reproducible retention times, and good instrument control generate unassailable data..."

Wehr discusses strategies for coupling LC and CE with MALDI–MS for use in proteomic studies.

Tim Wehr looks at the use of fast LC}MS for high-throughput analysis of pharmaceutical compounds.

What is the baseline telling us?

The authors investigated the analytical capabilities of quadrupole, time-of-flight, and Fourier transform mass analyzers for liquid chromatography electrospray mass spectrometry (LC-MS) applications.

This month's "Directions in Discovery" gives a brief overview of turbulent- flow liquid chromatography, a technique for fast separations. Two examples demonstrate the use of the technology for high-throughput bioanalytical separations in drug discovery.

The authors investigated the two most popular types of interfaces for benchtop LC–MS systems – the particle interface and the atmospheric-pressure ionization interface – to learn how the information obtained separately from the two can be complementary.

Despite their different levels of technological maturity, CE and LC coupled with electrospray ionization MS techniques can be operated at the same level of automation. However, they differ in their configuration, selectivity, sensitivity, and method development.

Current sample preparation procedures for LC–MS as applied to samples from biological matrices.