LC–MS

Untargeted analysis using liquid chromatography with tandem mass spectrometry (LC–MS/MS) chemical profiling is a valuable tool, but care needs to be taken with experimental design.

How can low-resolution mass spectrometry (LRMS) and high-resolution (HR) MS work together to provide unambiguous results in clinical and forensic toxicology?

The methodologies demonstrated here open the way to fully compliant at-line monitoring of monoclonal antibody quality attributes.

An overview of GLP regulations and related public standards.

Alasdair Matheson spoke to Jacob de Boer of Vrije Universiteit Amsterdam about a recent innovative research project investigating per- and polyfluoroalkyl substances (PFAS) in fast food packaging.

Researchers have developed a multitargeted internal calibration method for precise quantification of chronic kidney disease (CKD)-related endogenous metabolites using liquid chromatography–mass spectrometry (LC–MS).

Christopher Hudalla of ProVerde Laboratories Inc. discussed how using liquid chromatography–mass spectrometry (LC–MS) could be used to quantify specific classes of phospholipid (PPL) constituents that can help streamline cannabis extraction.

Okadaic acid (OA) is considered a marine toxin with distributed hydroxyl, polycyclic ether, and carboxyl groups, easily accumulated in shellfish and known to cause food poisoning in humans.

In a recent study, researchers from China presented a novel approach that uses a supramolecular solvent (SUPRAS) method for detecting bioactive compounds.

Webinar Date/Time: Airing 1: Tuesday October 10, 2023 at 9am EDT | 8am CDT | 6am PDT Airing 2: Tuesday October 10, 2023 at 1pm EDT | 12pm CDT | 10am PDT

Researchers from Corteva Agriscience tested a new approach for separating and quantifying small molecule structure elucidation.

A pair of scientists from Gdańsk University of Technology (GUT) in Gdańsk, Poland, used the method to analyze the presence of antibiotics in animal products like milk and eggs.

Brazilian scientists are testing a system to detect endocrine disruptors in wastewater samples to help improve public health.

Optimal reaction conditions for the desired deethylation were found to be mild, using only water and oxygen at or close to ambient temperatures.

There are many benefits of using high-resolution mass spectrometry (HRMS) in analyzing PFAS accumulating in living organisms. This article shows how HRMS, when combined with exposure-relevant mixtures, can help elucidate more about PFAS toxicity and exposure.

The investigation of airborne PFAS transmission is important in preserving the outdoor urban environment. The authors explain why GC–MS/MS and LC–MS/MS are the best techniques for analyzing airborne PFAS.

This instalment of “Column Watch” presents many of the highlighted topics and trends observed at this exceptionally well-run symposium.

Webinar Date/Time: Tue, Sep 19, 2023 11:00 AM EDT

The combination of the “bottom-up” approach with digest-free, direct-sequencing proteomics, along with the addition of a proteogenomics pipeline that identified missing data, yielded the determination of almost 3000 proteins.

Researchers in China studied a new process for measuring aberrant metabolites.

What critical components can help to resolve the separation challenges related to pesticides analysis in food?

Webinar Date/Time: Thursday, September 14th, 2023 at 8am PDT | 11am EDT | 4pm BST | 5pm CEST Thursday, September 14th, 2023 at 11am PDT | 2pm EDT | 7pm BST | 8pm CEST Friday, September 15th, 2023 at 11am CST | 12pm JST

Webinar Date/Time: Thursday, September 7, 2023 at 9am EST and 2pm ES

Webinar Date/Time: Thu, Aug 24, 2023 11:00 AM EDT

To gain a better understanding of phosphatidylinositols, scientists used different LC–MS/MS techniques to find classifications to use in identifying further species of Pls.

Increases and decreases in anthocyanin concentration, which relates to the level of sugars found in red wine, were observed at specific weekly intervals of the grape ripening process.

Trypsin is one of the most commonly used proteases in peptide mapping protocols because of its high level of specificity. However, trypsin alone is not always sufficient for full sequence coverage. In this article, the authors detail how trypsin was combined with chymotrypsin to overcome this, and the benefits of an automated platform.

An overview of different approaches for the qualitative and quantitative analysis of polysorbates.

Plant growth regulators (PGRs) have significant effects on plant physiological processes, but the complex matrices of plants, along with polarity and instability issues inherent with PGRs, complicate trace analysis of these compounds.

Sauce-flavor or sauce-aroma baijiu, one variant of a popular Chinese liquor, is treated with a fermentation starter called daqu, giving the concoction a unique taste profile, and scientists want more information about how it can inform the manufacturing of higher-quality baijiu.