April 30th 2024
Scientists from the Chinese Academy of Inspection and Quarantine recently published a review on how green solvents can further the evolution of microextraction techniques.
New Method Enables Accurate Analysis of Aminoglycoside Antibiotic Residues in Aquatic Products
June 30th 2023Researchers have developed an ultrahigh-pressure liquid chromatography (UHPLC)—tandem mass spectrometry (MS/MS) method for the simultaneous determination of 10 aminoglycoside antibiotics in aquatic products.
New LC–MS/MS Data Analysis Framework, MCnebula, Streamlines Untargeted Analysis
June 29th 2023Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.
UHPLC–MS/MS Quantifies Ultraviolet Filter Compounds in Chlorinated Canadian Waters
June 16th 2023An ultrahigh-pressure liquid chromatography–tandem mass spectrometry method (UHPLC–MS/MS) using polarity switching, preceded by solid-phase extraction (SPE), was used to quantify eight ultraviolet filter (UVF) compounds in chlorinated outdoor pools in Winnipeg.
Breakthrough MDLC–MS Method Enhances Characterization of Therapeutic Antibody Charge Variants
June 16th 2023Scientists have developed a breakthrough MDLC–MS method for in-depth characterization of charge variants in therapeutic antibodies. The innovative approach enables the detection and evaluation of rare charge variants, facilitating improved safety and efficacy in antibody development.
Unveiling Metabolite Interference for Reliable LC–MS Targeted Metabolomics Analysis
June 15th 2023New research emphasize the importance of identifying metabolite interference in LC–MS targeted metabolomics analysis to ensure accurate results. The study highlights the need for thorough investigation and resolution of metabolite interferences for reliable metabolite measurement in targeted metabolomics.
Breakthrough Method Enables Discovery of Natural Aldehydes for Metabolomics Research
June 14th 2023The development of a newly-designed Girard's reagent, HBP, as charged isobaric mass tags has enabled selective capture and sensitive detection of aldehyde metabolites. The LC–dNLS-MS/MS screening approach using this reagent has successfully facilitated the discovery of natural aldehydes and their profiling in complex samples.
LC–MS Methods Evaluate PFAS and Lipidomic Changes of Lettuce and Peanuts in Contaminated Soil
June 6th 2023In a talk at ASMS 2023, Rebecca L. Beres of the University of North Carolina at Chapel Hill focused on two types of analysis methods: liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) and a liquid chromatography, ion mobility spectrometry, and mass spectrometry (LC–IMS-MS) platform.
New Procedures Enhance Quality Control for Large-Scale Plasma Proteomics Analyses
May 24th 2023A recent study has introduced comprehensive quality control procedures for large-scale plasma proteomics analyses. The research provides valuable insights into optimizing performance, enhancing reproducibility, and ensuring quantitative accuracy in proteomics investigations.