Liquid Chromatography (LC/HPLC)

A high-throughput workflow for wide-targeted metabolomics in dried blood spots (DBS) is presented.

An investigation into whether 3D-printed sorbent devices introduce background contaminants in untargeted LC–QTOF-MS analyses.

This study delves into the challenges of online coupling, offering solutions to overcome peak distortion and enhance reliability in complex sample analysis. The resulting LC×SFC–MS/MS analysis allows differentiation of isomers in very complex samples, regardless of similar fragmentation patterns.

In this interview, Caroline West, professor at the University of Orléans and an active member of LCGC International’s editorial advisory board, discusses current perspectives on the fundamentals of SFC.

This article explores the use of chromatographic retention measurements in both LC and SFC to develop quantitative retention activity relationship (QRAR) models, offering a predictive tool for skin permeability without animal testing.

Discover a novel GC-based method for accurately analyzing organic carbonates in lithium-ion batteries without the need for complex calibrations.

This article explores the technological advancements in HPLC that enhance its role in analyzing PFAS in food, including innovations in column technology, detection systems, and sample preparation techniques.

In this interview, Gesa Schad from Shimadzu Europe, Germany, discusses how SFC is being used in practice, why she launched SFC For Dummies at HPLC 2025, and how common misconceptions surrounding the robustness of SFC have been addressed some time ago.

New upgrades to the Waters Corporation Alliance iS HPLC System Software systems were recently discussed at HPLC 2025.

Here is some of the most-read content posted on LCGC International this week.

An innovative workflow that combines iterative data-dependent acquisition (DDA) and data-independent acquisition (DIA) to enhance the identification of unknown pollutants in urban runoff is presented.

A new separation platform based on chromatographic techniques was used to characterize algae hydrocolloids.

This article describes the analytical challenges of chemical exposomics in food safety. The need for high-throughput, multi-platform approaches—such as LC–HRMS and GC–HRMS with IMS—to capture the full spectrum of potential contaminants in our food supply is emphasized.

Researchers from Waters and Biospring studied the contribution of nucleotide type and modifications on the retention and resolution of 22–24 nt long oligonucleotides in different chromatographic methods.

Here is some of the most-read content posted on LCGC International this week.

Grape pomace, a byproduct of the winery industry, holds various phenolic compounds within it. Scientists used liquid chromatography-based techniques to harvest these potentially beneficial components.

New QuEChERs-based methods were created to detect pesticide residues in commercial dry pet food.

Shea kernels contain bioactive secondary metabolites that can offer potential health benefits. Researchers aimed to learn more about these substances.

Here is some of the most popular content posted on LCGC International this week.

In the latest edition of "LC Troubleshooting", Dwight Stoll explores troubleshooting tips for liquid chromatography, particularly focusing on peak width challenges in large molecule separations and effective solutions.

This review highlights the high performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products that were introduced from 2024 to 2025, summarizing the technical specifications of each product and highlighting significant user benefits.

Microplastics can linger in aquatic ecosystems, and there are limited studies that evaluate those substances’ sorption kinetics. Researchers aimed to investigate the sorption behavior of cortisone on MPs.

Analyzing esters from marigold flowers can be a complicated process. Researchers created a new approach for separating these substances using ultra-high-performance low pressure supercritical chromatography (UHP/LP-SFC).

Water pollution management is an important process that faces difficulty with handling microplastics. University of Porto (Portugal) researchers aimed to optimize existing methods to help rectify this issue.

At the ASMS conference, Jack Henion emphasized contributions from colleagues and industry partners. He reflected on innovations that have shaped liquid chromatography–mass spectrometry (LC–MS) and the importance of teamwork in driving scientific breakthroughs.