Liquid Chromatography (LC/HPLC)

A type of traditional Chinese medicine that is believed to address depression symptoms, scientists recently studied the medicine’s components of the Xiaoyao Pill (XYP) to measure its effectiveness and identify its components.

In this month's edition of the LCGC Blog, discover how weighted least squares regression enhances quantitation accuracy in analytical chemistry, particularly for low-concentration analytes in HPLC.

A method has been developed to determine the enantiomeric composition of lactofen using RP-HPLC–DAD and a chemometric approach.

Here is some of the most popular content posted on LCGC International this week.

In a new study, researchers explored quantifying bile acids and tryptophan metabolites in human serum samples was created using ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC–MS/MS).

To address multi-drug resistance (MDR) among harmful substances, liquid chromatography–tandem mass spectrometry was used to test fosfomycin as a means of bypassing growing MDR amongst microorganisms.

Diflubenzuron and similar compounds can be signs of cattle fever ticks, which can cause morbidity in cattle. LC–MS/MS was recently tested as a means of detecting these disease-carrying insects.

Detecting tryptophan and other metabolites can be done using various techniques. Researchers created a new UHPLC–MS/MS-based method for quantifying these substances in human plasma.

While venous blood sampling can help gain understanding of patients’ health through phenolic compound analysis, this process can prove discomforting. Volumetric absorptive microsampling has recently been proposed as a more suitable and equally effective alternative.

Dimethylamine (DMA) is the smallest organic amine, typically being found in both humans and marine ecosystems. Dimitrios Tiskas of Hannover Medical School recently analyzed the nature and significance of DMA and other amines.

Here is some of the most popular content posted on LCGC International this week.

Kerstin Thurow, who achieved first professorship in “Laboratory Automation” at the Faculty of Engineering at the University of Rostock, in Germany, offers insights into the constantly-evolving field of laboratory automation.

LCGC International’s Rising Star of Separation Science Winner for the LC Category, Bram Huygens from the Vrije Universiteit Brussel in Brussels, Belgium, recaps the work he presented for his award and his current research focus.

Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.

High-performance liquid chromatography (HPLC) was recently used to detect acylated impurities in artificial hormones meant to treat prostate cancer symptoms.

Here is some of the most popular content posted on LCGC International this week.

The article discusses advancements in two-dimensional liquid and gas chromatography (LC×LC and GC×GC) to address the challenges of analyzing complex samples in non-target analysis.

Chinese researchers created a new approach for identifying and quantifying illegal additives in fruit and vegetable plums, types of often-consumed health-care foods.

In this month's edition of LC Troubleshooting, Dwight Stoll and his fellow researchers discuss both the benefits (improved peak shape/loading) and challenges (excessive interaction) associated with charge-doped reversed-phase (RP) columns for both analytical and preparative separations.

Here is some of the most popular content posted on LCGC International this week.

3D printing technology has potential in chromatography, but a major challenge is developing materials with both high porosity and robust mechanical properties. Recently, scientists compared the separation performances of eight different 3D printable stationary phases.

Polyamides can be difficult to characterize, despite their use in various aspects of everyday life. Vrije Universiteit Amsterdam researchers hoped to address this using a reversed-phase liquid chromatography (RPLC)-based approach.

As the push for green chemistry continues to grow, University of Almeria researchers created a review for ways chromatographic techniques could be more environmentally friendly.

This new study presents a validated QuEChERS–LC-MS/MS method for detecting eight persistent, mobile, and toxic substances in escarole, tomatoes, and tomato leaves irrigated with contaminated water.

Haloacetic acid detection has become important when analyzing drinking and swimming pool water. University of Tasmania researchers have begun applying capillary liquid chromatography as a means of detecting these substances.