May 3rd 2024
Here are the top five articles that the editors of LCGC International published this week.
New Findings Shed Light on Formation and Analysis of Doubly Charged Lipid-Metal Ion Complexes
June 30th 2023Researchers have discovered that phospholipids form doubly charged lipid-metal ion complexes during electrospray ionization (ESI), providing valuable insights into the analysis of phospholipid structures.
New Method Enables Accurate Analysis of Aminoglycoside Antibiotic Residues in Aquatic Products
June 30th 2023Researchers have developed an ultrahigh-pressure liquid chromatography (UHPLC)—tandem mass spectrometry (MS/MS) method for the simultaneous determination of 10 aminoglycoside antibiotics in aquatic products.
New LC–MS/MS Data Analysis Framework, MCnebula, Streamlines Untargeted Analysis
June 29th 2023Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.
New Method Enables Analysis of Polycyclic Aromatic Hydrocarbons in Plastics Production Intermediates
June 29th 2023A new method has been developed for detecting and quantifying polycyclic aromatic hydrocarbons (PAHs) in intermediates used in plastics production. The method, based on liquid chromatography column switching, allows for the analysis of 18 PAHs and addresses the lack of regulatory oversight for PAH concentrations in plastic intermediates.
UHPLC–MS/MS Quantifies Ultraviolet Filter Compounds in Chlorinated Canadian Waters
June 16th 2023An ultrahigh-pressure liquid chromatography–tandem mass spectrometry method (UHPLC–MS/MS) using polarity switching, preceded by solid-phase extraction (SPE), was used to quantify eight ultraviolet filter (UVF) compounds in chlorinated outdoor pools in Winnipeg.
Breakthrough MDLC–MS Method Enhances Characterization of Therapeutic Antibody Charge Variants
June 16th 2023Scientists have developed a breakthrough MDLC–MS method for in-depth characterization of charge variants in therapeutic antibodies. The innovative approach enables the detection and evaluation of rare charge variants, facilitating improved safety and efficacy in antibody development.
Unveiling Metabolite Interference for Reliable LC–MS Targeted Metabolomics Analysis
June 15th 2023New research emphasize the importance of identifying metabolite interference in LC–MS targeted metabolomics analysis to ensure accurate results. The study highlights the need for thorough investigation and resolution of metabolite interferences for reliable metabolite measurement in targeted metabolomics.
Breakthrough Method Enables Discovery of Natural Aldehydes for Metabolomics Research
June 14th 2023The development of a newly-designed Girard's reagent, HBP, as charged isobaric mass tags has enabled selective capture and sensitive detection of aldehyde metabolites. The LC–dNLS-MS/MS screening approach using this reagent has successfully facilitated the discovery of natural aldehydes and their profiling in complex samples.